{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:32:22Z","timestamp":1772836342967,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Education Commission of Chongqing","award":["KJ1712298"],"award-info":[{"award-number":["KJ1712298"]}]},{"name":"The Basic Research Project of Science and Technology Commission of Chongqing","award":["cstc2017jcyjAX0031"],"award-info":[{"award-number":["cstc2017jcyjAX0031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Supramolecular host-guest interaction and sensing between cationic pillar[5]arenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles (CP5@Au-NPs) as receptor and probe (rhodamine 123, R123), which shown high sensitivity and selectivity for L-carnitine detection. Due to the negative charge and molecular size properties of L-carnitine, it can be highly captured by the CP5 via electrostatic interactions and hydrophobic interactions. The host-guest mechanism between PP5 and L-carnitine was studied by 1H NMR and molecular docking, indicating that more affinity binding force of CP5 with L-carnitine. Therefore, a selective and sensitive fluorescent method was developed. It has a linear response of 0.1\u20132.0 and 2.0\u201325.0 \u03bcM and a detection limit of 0.067 \u03bcM (S\/N = 3). The fluorescent sensing platform was also used to detect L-carnitine in human serum and milk samples, which provided potential applications for the detection of drugs abuse and had path for guarding a serious food safety issues.<\/jats:p>","DOI":"10.3390\/s18113927","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T10:58:22Z","timestamp":1542193102000},"page":"3927","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6531-0251","authenticated-orcid":false,"given":"Xiaoping","family":"Tan","sequence":"first","affiliation":[{"name":"Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-3029","authenticated-orcid":false,"given":"Fawu","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650224, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linzong","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Geographical Science and Tourism Management, Chuxiong Normal University, Chuxiong 675000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1021\/ja043910f","article-title":"Protein biosensors based on biofunctionalized conical gold nanotubes","volume":"127","author":"Siwy","year":"2005","journal-title":"J. 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