{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:45:59Z","timestamp":1772693159444,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["HQJJ268702"],"award-info":[{"award-number":["HQJJ268702"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this study, we developed a surface plasmon resonance (SPR) sensor chip based on 2,4,6-trinitrotoluene (TNT) recognition peptide-modified single-walled carbon nanotubes (SWCNTs). The carboxylic acid-functionalized SWCNTs were immobilized on a 3-aminopropyltriethoxysilane (APTES)-modified SPR Au chip surface. Through \u03c0-stacking between the aromatic amino acids and SWCNTs, the TNT recognition peptide TNTHCDR3 was immobilized onto the surface of the SWCNTs. The peptide\u2013SWCNTs-modified sensor surface was confirmed and evaluated by atomic force microscope (AFM) observation. The peptide\u2013SWCNTs hybrid SPR sensor chip exhibited enhanced sensitivity with a limit of detection (LOD) of 772 ppb and highly selective detection compared with commercialized carboxymethylated dextran matrix sensor chips.<\/jats:p>","DOI":"10.3390\/s18124461","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T02:15:59Z","timestamp":1545099359000},"page":"4461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives"],"prefix":"10.3390","volume":"18","author":[{"given":"Jin","family":"Wang","sequence":"first","affiliation":[{"name":"Research and Development Center for Five-Sense Devices, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan"},{"name":"JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan"}]},{"given":"Sanyang","family":"Du","sequence":"additional","affiliation":[{"name":"JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan"},{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan"}]},{"given":"Takeshi","family":"Onodera","sequence":"additional","affiliation":[{"name":"JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan"},{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan"}]},{"given":"Rui","family":"Yatabe","sequence":"additional","affiliation":[{"name":"JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan"},{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4701-5352","authenticated-orcid":false,"given":"Masayoshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan"},{"name":"Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8552, Japan"}]},{"given":"Mina","family":"Okochi","sequence":"additional","affiliation":[{"name":"JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan"},{"name":"Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8552, Japan"}]},{"given":"Kiyoshi","family":"Toko","sequence":"additional","affiliation":[{"name":"Research and Development Center for Five-Sense Devices, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan"},{"name":"JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan"},{"name":"Institute for Advanced Study, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1021\/ja511512m","article-title":"Noncovalently functionalized monolayer graphene for sensitivity enhancement of surface plasmon resonance immunosensors","volume":"137","author":"Singh","year":"2015","journal-title":"J. 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