{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:15:14Z","timestamp":1772817314405,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vietnam National Foundation for Science and Technology Development","award":["104.06-2017.51"],"award-info":[{"award-number":["104.06-2017.51"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A3B1052702, J.S.K."],"award-info":[{"award-number":["2018R1A3B1052702, J.S.K."]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A mercury sensor (N-(rhodamine-6G)lactam-ethylenediamine-4-dimethylamino-cinnamaldehyde\u2014RLED) based on the Hg2+-promoted hydrolysis reaction has been designed and developed with a combination of theoretical calculations and experimental investigations. The interaction between RLED and Hg2+ goes through a fast-initial stage with formation of a 1:1 complex, followed by a slow hydrolysis process. The formation of durable intermediate complexes is due to quite a long hydrolysis reaction time. As a result, RLED can selectively detect Hg2+ in the presence of other metal ions, with a detection limit of 0.08 \u03bcM for the colorimetric method, and of 0.008 \u03bcM with the fluorescent method. In addition, the RLED sensor can work in a solution with a small amount of organic solvent, with a wide pH range from 5 to 10. The time-dependent density functional theory has been used for investigations of the excitation and de-excitation processes in RLED, intermediate complexes, and reaction products, thereby clarifying the changes in the fluorescence intensity before and after the RLED interacts with Hg2+ ions.<\/jats:p>","DOI":"10.3390\/s19010128","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T03:36:30Z","timestamp":1546486590000},"page":"128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hg2+-Promoted Spirolactam Hydrolysis Reaction: A Design Strategy for the Highly Selective Sensing of Hg2+ over other Metal Ions in Aqueous Media"],"prefix":"10.3390","volume":"19","author":[{"given":"Mai","family":"Bay","sequence":"first","affiliation":[{"name":"Department of Chemistry, Hue University, Hue City 84-234, Vietnam"},{"name":"Department of Chemistry, The University of Danang-University of Science and Education, Danang City 84-236, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Hien","sequence":"additional","affiliation":[{"name":"Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology, Hue City 84-234, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-2150","authenticated-orcid":false,"given":"Subin","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7241-1488","authenticated-orcid":false,"given":"Nguyen","family":"Trinh","sequence":"additional","affiliation":[{"name":"NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 84-28, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Trung","sequence":"additional","affiliation":[{"name":"Laboratory of Computational Chemistry and Modelling, Department of Chemistry, Quy Nhon University, Quy Nhon City 84-256, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7257-544X","authenticated-orcid":false,"given":"Pham","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Danang-University of Science and Technology, Danang City 84-236, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-1172","authenticated-orcid":false,"given":"Jong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong","family":"Quang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hue University, Hue City 84-234, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1021\/ol8022598","article-title":"Hg2+ Selective Fluorescent and Colorimetric Sensor: Its Crystal Structure and Application to Bioimaging","volume":"10","author":"Chen","year":"2008","journal-title":"Org. 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