{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:32:21Z","timestamp":1776976341765,"version":"3.51.4"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006537","name":"Campus France","doi-asserted-by":"publisher","award":["PHC Maghreb #39382RE"],"award-info":[{"award-number":["PHC Maghreb #39382RE"]}],"id":[{"id":"10.13039\/501100006537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this work, an enzymatic sensor, based on a bionanocomposite film consisting of a polyelectrolyte complex (PEC) (Chitosan\/kappa-carrageenan) doped with gold nanoparticles (AuNPs) encapsulating glucose oxidase (GOD) deposited on a gold electrode (Au) for glucose sensing, is described. Using the electrocatalytic synergy of AuNPs and GOD as a model of enzyme, the variation of the current (\u00b5A) as a function of the log of the glucose concentration (log [glucose]), shows three times higher sensitivity for the modified electrode (283.9) compared to that of the PEC\/GOD modified electrode (93.7), with a detection limit of about 5 \u00b5M and a linearity range between 10 \u00b5M and 7 mM. The response of the PEC\/AuNPs\/GOD based biosensor also presents good reproducibility, stability, and negligible interfering effects from ascorbic acid, uric acid, urea, and creatinine. The applicability of the PEC\/AuNPs\/GOD based biosensor was tested in glucose-spiked saliva samples and acceptable recovery rates were obtained.<\/jats:p>","DOI":"10.3390\/s19010154","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T11:34:26Z","timestamp":1546601666000},"page":"154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Highly Sensitive Voltammetric Glucose Biosensor Based on Glucose Oxidase Encapsulated in a Chitosan\/Kappa-Carrageenan\/Gold Nanoparticle Bionanocomposite"],"prefix":"10.3390","volume":"19","author":[{"given":"Ilhem","family":"Rassas","sequence":"first","affiliation":[{"name":"Institute of Analytical Sciences, University of Lyon, 69100 Villeurbanne, France"},{"name":"Laboratory of Advanced Materials and Interfaces, University of Monastir, 5000 Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Braiek","sequence":"additional","affiliation":[{"name":"Institute of Analytical Sciences, University of Lyon, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bonhomme","sequence":"additional","affiliation":[{"name":"Institute of Analytical Sciences, University of Lyon, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Bessueille","sequence":"additional","affiliation":[{"name":"Institute of Analytical Sciences, University of Lyon, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Raffin","sequence":"additional","affiliation":[{"name":"Institute of Analytical Sciences, University of Lyon, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Majdoub","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials and Interfaces, University of Monastir, 5000 Monastir, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-9273","authenticated-orcid":false,"given":"Nicole","family":"Jaffrezic-Renault","sequence":"additional","affiliation":[{"name":"Institute of Analytical Sciences, University of Lyon, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1248\/cpb.42.979","article-title":"A novel method for the preparation of controlled-release theophylline capsules coated with a polyelectrolyte complex of k-carrageenan and chitosan","volume":"42","author":"Tomida","year":"1994","journal-title":"Chem. 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