{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:10:34Z","timestamp":1767906634171,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T00:00:00Z","timestamp":1548460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["CTQ2017-83935-R-AEI\/FEDERUE"],"award-info":[{"award-number":["CTQ2017-83935-R-AEI\/FEDERUE"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A flexible electrode system entirely constituted by single-walled carbon nanotubes (SWCNTs) has been proposed as the sensor platform for \u03b2-nicotinamide adenine dinucleotide (NADH) detection. The performance of the device, in terms of potential at which the electrochemical process takes place, significantly improves by electrochemical functionalization of the carbon-based material with a molecule possessing an o-hydroquinone residue, namely caffeic acid. Both the processes of SWCNT functionalization and NADH detection have been studied by combining electrochemical and spectroelectrochemical experiments, in order to achieve direct evidence of the electrode modification by the organic residues and to study the electrocatalytic activity of the resulting material in respect to functional groups present at the electrode\/solution interface. Electrochemical measurements performed at the fixed potential of +0.30 V let us envision the possible use of the device as an amperometric sensor for NADH detection. Spectroelectrochemistry also demonstrates the effectiveness of the device in acting as a voltabsorptometric sensor for the detection of this same analyte by exploiting this different transduction mechanism, potentially less prone to the possible presence of interfering species.<\/jats:p>","DOI":"10.3390\/s19030518","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:40:55Z","timestamp":1548733255000},"page":"518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Flexible Platform of Electrochemically Functionalized Carbon Nanotubes for NADH Sensors"],"prefix":"10.3390","volume":"19","author":[{"given":"Aranzazu","family":"Heras","sequence":"first","affiliation":[{"name":"Department of Chemistry, Universidad de Burgos, Pza. Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Vulcano","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, Universit\u00e0 di Modena e Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy"},{"name":"Institute of Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), via P. Gobetti 101, 40129 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Garoz-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidad de Burgos, Pza. Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Porcelli","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, Universit\u00e0 di Modena e Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Terzi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, Universit\u00e0 di Modena e Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Colina","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidad de Burgos, Pza. Misael Ba\u00f1uelos s\/n, E-09001 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Seeber","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, Universit\u00e0 di Modena e Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy"},{"name":"Institute of Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), via P. Gobetti 101, 40129 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Zanardi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, Universit\u00e0 di Modena e Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy"},{"name":"Institute of Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), via P. Gobetti 101, 40129 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1567-5394(02)00047-6","article-title":"Modified electrodes for NADH oxidation and dehydrogenase-based biosensors","volume":"56","author":"Bartlett","year":"2002","journal-title":"Bioelectrochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01242656","article-title":"Catalytic electrooxidation of NADH for dehydrogenase amperometric biosensors","volume":"126","author":"Katakis","year":"1997","journal-title":"Mikrochim Acta."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/BA20020052","article-title":"Measurement of NADH concentration in normal and malignant human tissues from breast and oral cavity","volume":"37","author":"Uppal","year":"2003","journal-title":"Biotechnol. Appl. 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