{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T01:32:52Z","timestamp":1769391172642,"version":"3.49.0"},"reference-count":41,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61605206, 61771138, 11604332, 11504372"],"award-info":[{"award-number":["61605206, 61771138, 11604332, 11504372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Municipal Science and Technology Commission","award":["cstc2017jcyjAX0051"],"award-info":[{"award-number":["cstc2017jcyjAX0051"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFF0106303, 2016YFC0101300, 2016YFC0101002"],"award-info":[{"award-number":["2017YFF0106303, 2016YFC0101300, 2016YFC0101002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Terahertz signature detection of biological samples in aqueous solution remains a great challenge due to the strong terahertz absorption of water. Here we propose a new preparation process for fabricating a microfluidic chip and use it as an effective sensor to probe the terahertz absorption signatures of microcystin aptamer (a linear single-stranded DNA with 60 nucleotides) dissolved in TE buffer with different concentrations. The microfluidic chip made of silicon includes thousands of 2.4 \u03bcm \u00d7 2.4 \u03bcm square-cross-section channels. One repeatable terahertz absorption signature is detected and recognized around 830 GHz, fitted to a Lorentz oscillator. This signature is theorized to originate from the bending of hydrogen bonds formed between adjacent hydrated DNA bases surrounded by water molecules. Furthermore, the low-lying vibrational modes are also investigated by molecular dynamics simulations which suggest that strong resonant oscillations are highly probable in the 815\u2013830 GHz frequency band.<\/jats:p>","DOI":"10.3390\/s19030534","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:40:55Z","timestamp":1548733255000},"page":"534","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Terahertz Spectroscopic Signatures of Microcystin Aptamer Solution Probed with a Microfluidic Chip"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-6629","authenticated-orcid":false,"given":"Mingkun","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Electrical Engineering and Intelligentization, Dongguan University of Technology, Dongguan, Guangdong 523808, China"},{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-0819","authenticated-orcid":false,"given":"Zhongbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjie","family":"Tang","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-0672","authenticated-orcid":false,"given":"Huabin","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihan","family":"Yan","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongshan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering and Intelligentization, Dongguan University of Technology, Dongguan, Guangdong 523808, China"},{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Liang","family":"Cui","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China"},{"name":"College of Instrumentation Science and Electrical Engineering, Jilin University, Changchun 130061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ymeth.2010.05.007","article-title":"Combining Thz Spectroscopy and Md Simulations to Study Protein-Hydration Coupling","volume":"52","author":"Heyden","year":"2010","journal-title":"Methods"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1002\/anie.200802281","article-title":"Real-Time Detection of Protein-Water Dynamics Upon Protein Folding by Terahertz Absorption Spectroscopy","volume":"47","author":"Kim","year":"2008","journal-title":"Angew. 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