{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:14:32Z","timestamp":1768565672239,"version":"3.49.0"},"reference-count":25,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006134","name":"Foundation for Promotion of Material Science and Technology of Japan","doi-asserted-by":"publisher","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/501100006134","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>It has been shown that the faradic current at an electrode grafted with molecularly imprinted polymer (MIP) is sensitive to the specific target molecule used as the template. This phenomenon is applicable to sensors with very high selectivity, but the sensing mechanism is still a black box. We investigated the size sensitivity of nanoparticles of molecularly imprinted polymers (MIP-NPs) to a specific interaction for determination of the mechanism of the gate effect and its feasibility for new applications. Nanoparticles of poly(methacryloxy ethyl trimethylammonium chloride-co-acrylamide-co-methylenebisacrylamide) imprinted with heparin immobilized on glass beads were synthesized. The diameter of the MIP-NPs of heparin was increased by the presence of the heparin template but was insensitive to chondroitin sulfate C (CSC), the analogue of heparin. The high selectivity of the MIP-NPs was consistent with the selectivity of electrodes grafted with a heparin-imprinted polymer in our previous studies. The quartz crystal microbalance probes immobilizing heparin or CSC were sensitive to MIP-NPs, which indicates that the binding ability of MIP-NP does not discriminate between the template and other glycosaminoglycans. These results indicate that the size of the MIP-NP is sensitive to the matched binding with the template through the imprinted cavity.<\/jats:p>","DOI":"10.3390\/s19102415","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T11:19:27Z","timestamp":1558955967000},"page":"2415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Size of Heparin-Imprinted Nanoparticles Reflects the Matched Interactions with the Target Molecule"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-2720","authenticated-orcid":false,"given":"Yasuo","family":"Yoshimi","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry, Shibaura Institute of Technology, Tokyo 135-8548, Japan"},{"name":"QOL improvement and Life Science Consortium, Shibaura Institute of Technology, Tokyo 135-8548, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Oino","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Shibaura Institute of Technology, Tokyo 135-8548, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Shibaura Institute of Technology, Tokyo 135-8548, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Muguruma","sequence":"additional","affiliation":[{"name":"QOL improvement and Life Science Consortium, Shibaura Institute of Technology, Tokyo 135-8548, Japan"},{"name":"Department of Electronic Engineering, Shibaura Institute of Technology, Tokyo 135-8548, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Moczko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK"},{"name":"Departamento de Qu\u00edmica Ambiental, Facultad de Ciencias, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n 4090541, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Piletsky","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Li, S., Ge, Y., Piletsky, S.A., and Lunec, J. 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