{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:29:16Z","timestamp":1761989356319,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A simple and rapid As3+ detection method using 3-nitro-L-tyrosine (N-Tyr) is reported. We discovered the specific property of N-Tyr, which specifically chelates As3+. The reaction between As3+ and N-Tyr induces a prompt color change to vivid yellow, concomitantly increasing the absorbance at 430 nm. The selectivity for As3+ is confirmed by competitive binding experiments with various metal ions (Hg2+, Pb2+, Cd2+, Cr3+, Mg2+, Ni2+, Cu2+, Fe2+, Ca2+, Zn2+, and Mn2+). Also, the N-Tyr binding site, binding affinity, and As3+\/N-Tyr reaction stoichiometry are investigated. The specific reaction is utilized to design a sensor that enables the quantitative detection of As3+ in the 0.1\u2013100 \u03bcM range with good linearity (R2 = 0.995). Furthermore, the method\u2019s applicability for the analysis of real samples, e.g., tap and river water, is successfully confirmed, with good recoveries (94.32\u2013109.15%) using As3+-spiked real water samples. We believe that our discovering and its application for As3+ analysis can be effectively utilized in environmental analyses such as those conducted in water management facilities, with simplicity, rapidity, and ease.<\/jats:p>","DOI":"10.3390\/s19132857","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T08:47:13Z","timestamp":1561625233000},"page":"2857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Simple and Label-Free Detection of As3+ using 3-nitro-L-tyrosine as an As3+-chelating Ligand"],"prefix":"10.3390","volume":"19","author":[{"given":"Jin-Ho","family":"Park","sequence":"first","affiliation":[{"name":"Department of Chemistry, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-Gu, Gwangju 61005, Korea"},{"name":"Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyuho","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-Gu, Gwangju 61005, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donggu","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-Gu, Gwangju 61005, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Jung","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-Gu, Gwangju 61005, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Ju","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-Gu, Gwangju 61005, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3525-0048","authenticated-orcid":false,"given":"Min-Gon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-Gu, Gwangju 61005, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1039\/C5EW00099H","article-title":"Detection of trace arsenic in drinking water: Challenges and opportunities for microfluidics","volume":"1","author":"Yogarajah","year":"2015","journal-title":"Environ. 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