{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:01:26Z","timestamp":1774983686260,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21805308"],"award-info":[{"award-number":["21805308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017QB015"],"award-info":[{"award-number":["ZR2017QB015"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"FUNDAMENTAL RESEARCH FUNDS FOR THE CENTRAL UNIVERSITIES","doi-asserted-by":"publisher","award":["19CX05001A"],"award-info":[{"award-number":["19CX05001A"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Hierarchical Ni-Co double transition metal hydroxide nanosheets have been explored as an effective strategy for the design of nonenzymatic glucose sensors. Ni-Co hydroxide nanosheets constructed hollow cubes were successfully synthesized by using Cu2O cubes as templates and subsequently etched by Na2S2O3 to achieve a hollow cubic structure. The molar ratio between Ni and Co was tuned by varying the precursor ratio of NiCl2 and CoCl2. It was observed by transmission electron microscopy (TEM) that the increasing Ni precursor resulted in particle morphology, and the increasing ratio of the Co precursor resulted in more lamellar morphology. The sample with the composition of Ni0.7Co0.3(OH)2 displayed the best performance for glucose sensing with high selectivity (1541 \u03bcA mM\u20131 cm\u20132), low detection limit (3.42 \u00b5M with S\/N = 3), and reasonable selectivity. Similar strategies could be applied for the design of other electrode materials with high efficiency for nonenzymatic glucose determination.<\/jats:p>","DOI":"10.3390\/s19132938","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T11:14:49Z","timestamp":1562152489000},"page":"2938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Synthesis of Ni-Co Hydroxide Nanosheets Constructed Hollow Cubes for Electrochemical Glucose Determination"],"prefix":"10.3390","volume":"19","author":[{"given":"Fengchao","family":"Sun","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao 266580, China"},{"name":"School of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shutao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Science, China University of Petroleum (East China), Qingdao 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Science, China University of Petroleum (East China), Qingdao 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingtong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinping","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao 266580, China"},{"name":"School of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China"},{"name":"College of Science, China University of Petroleum (East China), Qingdao 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao 266580, China"},{"name":"School of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1021\/cr068123a","article-title":"Electrochemical glucose biosensors","volume":"108","author":"Wang","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aca.2005.05.080","article-title":"Electrochemical non-enzymatic glucose sensors","volume":"556","author":"Park","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S1452-3981(23)15359-4","article-title":"Electrochemical Non-enzymatic Glucose Sensors: A Perspective and an Evaluation","volume":"5","author":"Toghill","year":"2010","journal-title":"Int. J. Electrochem. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/1616-8984(200201)10:1<107::AID-SEUP107>3.0.CO;2-Q","article-title":"Glucose Biosensors: 40 Years of Advances and Challenges","volume":"10","author":"Wang","year":"2002","journal-title":"Sens. Update"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1002\/adhm.201500369","article-title":"One-Pot Fabrication of Dendritic NiO@carbon\u2013nitrogen Dot Electrodes for Screening Blood Glucose Level in Diabetes","volume":"4","author":"Akhtar","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1962.tb13623.x","article-title":"Electrode systems for continuous monitoring in cardiovascular surgery","volume":"102","author":"Clark","year":"1962","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.colsurfa.2016.08.076","article-title":"Non-enzymatic glucose sensor based on facial hydrothermal synthesized NiO nanosheets loaded on glassy carbon electrode","volume":"509","author":"Wang","year":"2016","journal-title":"Colloids Surf. A: Physicochem. Eng. Asp."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0956-5663(92)87013-F","article-title":"Glucose oxidase: an ideal enzyme","volume":"7","author":"Wilson","year":"1992","journal-title":"Biosens. Bioelectron."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.colsurfa.2018.10.067","article-title":"The hybrid of gold nanoparticles and Ni(OH)2 nanosheet for non-enzymatic glucose sensing in food","volume":"561","author":"Xu","year":"2019","journal-title":"Colloids Surf. A: Physicochem. Eng. Asp."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.apsusc.2018.10.124","article-title":"One step synthesis of hierarchical Cu nanoparticles-Co(OH)2 nanoflakes\/Nifoam electrode for ultrasensitive detection of glucose","volume":"468","author":"Wang","year":"2019","journal-title":"Appl. Surf. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.matlet.2018.09.054","article-title":"Highly-branched dendrite cuprous oxide films for non-enzymatic amperometric glucose sensor","volume":"234","author":"Sun","year":"2019","journal-title":"Mater. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/celc.201801420","article-title":"Tuning the NiO Thin Film Morphology on Carbon Nanotubes by Atomic Layer Deposition for Enzyme-Free Glucose Sensing","volume":"6","author":"Raza","year":"2019","journal-title":"ChemElectroChem"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.snb.2018.09.075","article-title":"Surface engineering of nickel selenide nanosheets array on nickel foam: An integrated anode for glucose sensing","volume":"278","author":"Ma","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.snb.2018.09.076","article-title":"Co-MOF nanosheet array: A high-performance electrochemical sensor for non-enzymatic glucose detection","volume":"278","author":"Li","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.snb.2018.10.150","article-title":"Nanoporous gold induced vertically standing 2D NiCo bimetal-organic framework nanosheets for non-enzymatic glucose biosensing","volume":"281","author":"Li","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jelechem.2018.10.054","article-title":"New route for the synthesis of nickel (II) oxide nanostructures and its application as non-enzymatic glucose sensor","volume":"832","author":"Heyser","year":"2019","journal-title":"Electroanal. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1039\/C6TB02037B","article-title":"Advances in non-enzymatic glucose sensors based on metal oxides","volume":"4","author":"Zhu","year":"2016","journal-title":"Mater. Chem. B"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"84893","DOI":"10.1039\/C6RA12506A","article-title":"Recent advances in non-enzymatic electrochemical glucose sensors based on non-precious transition metal materials: opportunities and challenges","volume":"6","author":"Niu","year":"2016","journal-title":"RSC Adv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.colsurfa.2018.10.010","article-title":"Fabrication and electrochemical properties of alizarin-aminophenylboronic acid ensembled with layered double hydroxide for glucose sensing selectivity","volume":"560","author":"Wu","year":"2019","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jelechem.2018.06.028","article-title":"Preparation of one dimensional silver nanowire\/nickel-cobalt layered double hydroxide and its electrocatalysis of glucose","volume":"823","author":"Xu","year":"2018","journal-title":"J. Electroanal. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.snb.2018.06.038","article-title":"Non-enzymatic glucose sensor with high sensitivity based on Cu-Al layered double hydroxides","volume":"273","author":"Wang","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1002\/elan.201800362","article-title":"Integrating Ultrathin Polypyrrole Framework on Nickel-Cobalt Layered Double Hydroxide as an Amperometric Sensor for Non-enzymatic Glucose Determination","volume":"30","author":"Ni","year":"2018","journal-title":"Electroanalysis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16125","DOI":"10.1016\/j.matpr.2018.05.098","article-title":"Synthesis of Nickel-Aluminium Layered Double Hydroxide and itsApplication in Non-Enzymatic Glucose Sensing","volume":"5","author":"Kumar","year":"2018","journal-title":"Mater. Today Proc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ab.2017.01.005","article-title":"Synthesis and characterization of graphene quantum dots\/CoNiAl-layered double-hydroxide nanocomposite: Application as a glucose sensor","volume":"521","author":"Samuei","year":"2017","journal-title":"Anal. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/elan.201700025","article-title":"Synthesis and characterization of graphene quantum dots\/CoNiAl-layered double-hydroxide nanocomposite: Application as a glucose sensor","volume":"29","author":"Lu","year":"2017","journal-title":"Electroanalysis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/elan.201500599","article-title":"Dispersed Nickel Nanoparticles on Flower-like Layered Nickel-Cobalt Double Hydroxides for Non-enzymic Amperometric Sensing of Glucose","volume":"28","author":"Chen","year":"2016","journal-title":"Electroanalysis"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.electacta.2014.11.115","article-title":"Non-enzymatic glucose sensor based on Au nanoparticles decorated ternary Ni-Al layered double hydroxide\/single-walled carbon nanotubes\/graphene nanocomposite","volume":"152","author":"Fu","year":"2015","journal-title":"Electrochim. Acta"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.electacta.2016.12.104","article-title":"Three-dimensional NiCo Layered Double Hydroxide Nanosheets Array on Carbon Cloth, Facile Preparation and Its Application in Highly Sensitive Enzymeless Glucose Detection","volume":"224","author":"Wang","year":"2017","journal-title":"Electrochim. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s11671-019-2966-2","article-title":"A Simple Electrochemical Route to Access Amorphous Co-Ni Hydroxide for Non-enzymatic Glucose Sensing","volume":"14","author":"Li","year":"2019","journal-title":"Nanoscale Res. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1039\/C8NA00231B","article-title":"A bifunctional nonenzymatic flexible glucose microsensor based on CoFe-Layered double hydroxide","volume":"1","author":"Cui","year":"2019","journal-title":"Nanoscale Adv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1002\/smll.201203076","article-title":"Amorphous Ni(OH)2 nanoboxes: fast fabrication and enhanced sensing for glucose","volume":"9","author":"Nai","year":"2013","journal-title":"Small"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1500003","DOI":"10.1002\/advs.201500003","article-title":"Bio-inspired leaf-mimicking nanosheet\/nanotube heterostructure as a highly efficient oxygen evolution catalyst","volume":"2","author":"Wang","year":"2015","journal-title":"Adv. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jallcom.2017.06.170","article-title":"Direct successive ionic layer adsorption and reaction (SILAR) synthesis of nickel and cobalt hydroxide composites for supercapacitor applications","volume":"722","author":"Lee","year":"2017","journal-title":"J. Alloy. Compd."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1039\/c3ta01402a","article-title":"One-pot synthesis of a mesoporous NiCo2O4 nanoplatelet and graphene hybrid and its oxygen reduction and evolution activities as an efficient bi-functional electrocatalyst","volume":"1","author":"Lee","year":"2013","journal-title":"J. Mater. Chem. A"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.snb.2018.07.141","article-title":"One-step construction of hierarchical Ni(OH)2\/RGO\/Cu2O on Cu foil for ultra-sensitive non-enzymatic glucose and hydrogen peroxide detection","volume":"274","author":"Wu","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1002\/elan.201100271","article-title":"Highly sensitive amperometric glucose sensors based on nanostructured \u03b1-Ni(OH)2 electrodes","volume":"23","author":"Martins","year":"2011","journal-title":"Electroanalysis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/elan.201800002","article-title":"Facile Synthesis of Ni(OH)2 Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non-enzymatic Glucose Sensor","volume":"30","author":"Chelaghmia","year":"2018","journal-title":"Electroanalysis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.snb.2014.12.113","article-title":"Self-supported porous CoOOH nanosheet arrays as a non-enzymatic glucose sensor with good reproducibility","volume":"210","author":"Zhang","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.snb.2015.08.119","article-title":"Synthesis of hierarchical Ni(OH)2 hollow nanorod via chemical bath deposition and its glucose sensing performance","volume":"222","author":"Yang","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.aca.2015.04.038","article-title":"Three-dimensional roselike alpha-Ni(OH)(2) assembled from nanosheet building blocks for non-enzymatic glucose detection","volume":"880","author":"Lu","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.snb.2012.11.035","article-title":"Direct growth of vertically aligned arrays of Cu(OH)2 nanotubes for the electrochemical sensing of glucose","volume":"177","author":"Zhou","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1007\/s10008-012-1718-3","article-title":"Highly enhanced electrocatalytic oxidation of glucose on Cu(OH)2\/CuO nanotube arrays modified copper electrode","volume":"16","author":"Yang","year":"2012","journal-title":"J. Solid State Electrochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpowsour.2012.06.065","article-title":"Highly stabilized alpha-NiCo(OH)2 nanomaterials for high performance device application","volume":"218","author":"Martins","year":"2012","journal-title":"J. Power Sources"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jallcom.2015.01.213","article-title":"Controllable preparation of hierarchically core-shell structure NiO\/C microspheres for non-enzymatic glucose sensor","volume":"632","author":"Cui","year":"2015","journal-title":"J. Alloy. Compd."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jelechem.2015.09.011","article-title":"Hierarchical flower-like NiO hollow microspheres for non-enzymatic glucose sensors","volume":"757","author":"Cui","year":"2015","journal-title":"J. Electroanal. Chem."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/19\/13\/2938\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:02:20Z","timestamp":1760187740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/19\/13\/2938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":45,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["s19132938"],"URL":"https:\/\/doi.org\/10.3390\/s19132938","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,3]]}}}