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An ageing world population have placed demands on the use of assistive technology and, in particular, towards novel healthcare devices and sensors. Besides the electromagnetic field immunity, polymer optical fiber (POF) sensors have additional advantages due to their material features such as high flexibility, lower Young\u2019s modulus (enabling high sensitivity for mechanical parameters), higher elastic limits, and impact resistance. Such advantages are well-aligned with the instrumentation requirements of many healthcare devices and in movement analysis. Aiming at these advantages, this review paper presents the state-of-the-art developments of POF sensors for healthcare applications. A plethora of healthcare applications are discussed, which include movement analysis, physiological parameters monitoring, instrumented insoles, as well as instrumentation of healthcare robotic devices such as exoskeletons, smart walkers, actuators, prostheses, and orthosis. This review paper shows the feasibility of using POF sensors in healthcare applications and, due to the aforementioned advantages, it is possible to envisage a further widespread use of such sensors in this research field in the next few years.<\/jats:p>","DOI":"10.3390\/s19143156","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T03:11:42Z","timestamp":1563419502000},"page":"3156","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":195,"title":["Polymer Optical Fiber Sensors in Healthcare Applications: A Comprehensive Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-0619","authenticated-orcid":false,"given":"Arnaldo G.","family":"Leal-Junior","sequence":"first","affiliation":[{"name":"Mechanical Engineering Department, Federal University of Esp\u00edrito Santo, Esp\u00edrito Santo 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-5076","authenticated-orcid":false,"given":"Camilo A.R.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Graduate Program in Electrical Engineering, Federal University of Esp\u00edrito Santo, Esp\u00edrito Santo 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia M.","family":"Avellar","sequence":"additional","affiliation":[{"name":"Graduate Program in Electrical Engineering, Federal University of Esp\u00edrito Santo, Esp\u00edrito Santo 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-2425","authenticated-orcid":false,"given":"Maria Jos\u00e9","family":"Pontes","sequence":"additional","affiliation":[{"name":"Graduate Program in Electrical Engineering, Federal University of Esp\u00edrito Santo, Esp\u00edrito Santo 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-5092","authenticated-orcid":false,"given":"Carlos","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Physics and I3N, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0687-3967","authenticated-orcid":false,"given":"Anselmo","family":"Frizera","sequence":"additional","affiliation":[{"name":"Graduate Program in Electrical Engineering, Federal University of Esp\u00edrito Santo, Esp\u00edrito Santo 29075-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"013002","DOI":"10.1088\/0964-1726\/20\/1\/013002","article-title":"Polymer optical fiber sensors\u2014A review","volume":"20","author":"Peters","year":"2011","journal-title":"Smart Mater. 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