{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:48:45Z","timestamp":1780602525706,"version":"3.54.1"},"reference-count":34,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["17162MFDS065"],"award-info":[{"award-number":["17162MFDS065"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The globalization of food distribution has made necessary to secure safe products to the general consumers through the rapid detection of harmful additives on the field. For this purpose, we developed a cuvette-type localized surface plasmon resonance (LSPR) sensor that can be easily used by consumers with conventional ultraviolet-visible light spectrophotometer for in-situ measurements. Gold nanoparticles were uniformly deposited on a transparent substrate via a self-assembly method to obtain a plasmonically active chip, and the chemical receptor p-nitroaniline (p-NA) was functionalized to stabilize the device sensitivity under external temperature and pH conditions. The fabricated chip was fixed onto a support and combined with a cuvette-type LSPR sensor. To evaluate the applicability of this sensor on the field, sensitivity and quantitative analysis experiments were conducted onto melamine as a model sample from harmful food additives. Under optimal reaction condition (2 mM p-NA for 20 min), we achieved an excellent detection limit (0.01 ppb) and a dynamic range allowing quantitative analysis over a wide concentration range (0.1\u20131000 ppb) from commercially available milk powder samples.<\/jats:p>","DOI":"10.3390\/s19183839","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T02:59:22Z","timestamp":1567738762000},"page":"3839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cuvette-Type LSPR Sensor for Highly Sensitive Detection of Melamine in Infant Formulas"],"prefix":"10.3390","volume":"19","author":[{"given":"Seo","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"},{"name":"Electron Microscopy Research Center, Korea Basic Science Institute, Daejeon 34133, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuseon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungsil","family":"Moon","sequence":"additional","affiliation":[{"name":"New Hazardous Substances Team, Department of Food Safety Evaluation, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si 28159, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"New Hazardous Substances Team, Department of Food Safety Evaluation, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si 28159, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8918-0957","authenticated-orcid":false,"given":"Tae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiim","family":"Moon","sequence":"additional","affiliation":[{"name":"New Hazardous Substances Team, Department of Food Safety Evaluation, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si 28159, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyang","family":"Chun","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1612-4473","authenticated-orcid":false,"given":"Yun","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, Incheon 402-751, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.foodcont.2015.09.026","article-title":"Prediction of food fraud type using data from Rapid Alert System for Food and Feed (RASFF) and Bayesian network modelling","volume":"61","author":"Bouzembrak","year":"2016","journal-title":"Food Control"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1750-3841.2012.02657.x","article-title":"Development and Application of a Database of Food Ingredient Fraud and Economically Motivated Adulteration from 1980 to 2010","volume":"77","author":"Moore","year":"2012","journal-title":"J. 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