{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:33:54Z","timestamp":1768343634978,"version":"3.49.0"},"reference-count":28,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Russian Scientific Foundation","award":["18-19-00090"],"award-info":[{"award-number":["18-19-00090"]}]},{"name":"the Ministry of Education and Science of the Russian Federation","award":["3.1438.2017\/46"],"award-info":[{"award-number":["3.1438.2017\/46"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG samples were prepared in various shapes that are suitable for different characterization techniques. Thin cylindrical samples were used to simulate the case of targeted drug delivery test through blood vessels. Samples of larger size that were in the shape of cylindrical plates were used for the evaluation of the FG applicability as substitutes for damaged structures, such as bone or cartilage tissues. Regardless of the shape of the samples and the conditions of their location, the boundaries of FG were confidently visualized over the entire range of concentrations of MNPs while using medical ultrasound. The amplitude of the reflected echo signal was higher for the higher concentration of MNPs in the gel. This result was not related to the influence of the MNPs on the intensity of the reflected echo signal directly, since the wavelength of the ultrasonic effect used is much larger than the particle size. Qualitative theoretical model for the understanding of the experimental results was proposed while taking into account the concept that at the acoustic oscillations of the hydrogel, the macromolecular net, and water in the gel porous structure experience the viscous Stocks-like interaction.<\/jats:p>","DOI":"10.3390\/s19183959","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:32:41Z","timestamp":1568370761000},"page":"3959","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ferrogels Ultrasonography for Biomedical Applications"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-2873","authenticated-orcid":false,"given":"Felix A.","family":"Blyakhman","sequence":"first","affiliation":[{"name":"Ural State Medical University, 620028 Ekaterinburg, Russia"},{"name":"Institute of Natural Sciences and Mathematics Ural Federal University, 620002 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-6185","authenticated-orcid":false,"given":"Sergey Yu","family":"Sokolov","sequence":"additional","affiliation":[{"name":"Ural State Medical University, 620028 Ekaterinburg, Russia"},{"name":"Institute of Natural Sciences and Mathematics Ural Federal University, 620002 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander P.","family":"Safronov","sequence":"additional","affiliation":[{"name":"Institute of Natural Sciences and Mathematics Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"Institute of Electrophysics, Ural Division RAS, 620016 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga A.","family":"Dinislamova","sequence":"additional","affiliation":[{"name":"Ural State Medical University, 620028 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana F.","family":"Shklyar","sequence":"additional","affiliation":[{"name":"Ural State Medical University, 620028 Ekaterinburg, Russia"},{"name":"Institute of Natural Sciences and Mathematics Ural Federal University, 620002 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-9852","authenticated-orcid":false,"given":"Andrey Yu","family":"Zubarev","sequence":"additional","affiliation":[{"name":"Institute of Natural Sciences and Mathematics Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"M.N. Mikheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-1637","authenticated-orcid":false,"given":"Galina V.","family":"Kurlyandskaya","sequence":"additional","affiliation":[{"name":"Institute of Natural Sciences and Mathematics Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"Departamento de Electricidad y Electr\u00f3nica and BCMaterials, Universidad del Pa\u00eds Vasco UPV\/EHU, 48080 Bilbao, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"DeRossi, D., Kajiwara, K., Osada, Y., and Yamauchi, A. (1991). Polymer Gels: Fundamentals and Biomedical Applications, Plenum Press.","DOI":"10.1007\/978-1-4684-5892-3"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/12_2006_104","article-title":"Magnetic Field-Responsive Smart Polymer Composites","volume":"206","author":"Filipcsei","year":"2007","journal-title":"Adv. Polym. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/adfm.201201708","article-title":"Magnetic Hydrogels and their potential biomedical applications","volume":"23","author":"Li","year":"2013","journal-title":"Adv. Func. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Safronov, A.P., Mikhnevich, E.A., Lotfollahi, Z., Blyakhman, F.A., Sklyar, T.F., Varga, A.L., Medvedev, A.I., Armas, S.F., and Kurlyandskaya, G.V. (2018). Polyacrylamide Ferrogels with Magnetite or Strontium Hexaferrite: Next Step in the Development of Soft Biomimetic Matter for Biosensor Applications. Sensors, 18.","DOI":"10.3390\/s18010257"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.biomaterials.2018.01.049","article-title":"Improved magnetic regulation of delivery profiles from ferrogels","volume":"161","author":"Kennedy","year":"2018","journal-title":"Biomaterials"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1016\/j.rinp.2017.09.042","article-title":"Polyacrylamide ferrogels with embedded maghemite nanoparticles for biomedical engineering","volume":"7","author":"Blyakhman","year":"2017","journal-title":"Results Phys."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1039\/C7SM00388A","article-title":"Effect of particle concentration on the microstructural and macromechanical properties of biocompatible magnetic hydrogels","volume":"13","author":"Campos","year":"2017","journal-title":"Soft Matter"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Blyakhman, F., Buznikov, N., Sklyar, T., Safronov, A., Golubeva, E., Svalov, A., Sokolov, S., Melnikov, G., Orue, I., and Kurlyandskaya, G. (2018). Mechanical, electrical and magnetic properties of ferrogels with embedded iron oxide nanoparticles obtained by laser target evaporation: Focus on multifunctional biosensor applications. Sensors, 18.","DOI":"10.3390\/s18030872"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lopez-Lopez, M.T., Scionti, G., Oliveira, A.C., Duran, J.D.G., Campos, A., Alaminos, M., and Rodriguez, I.A. (2015). Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133878"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1850060","DOI":"10.1142\/S0219519418500604","article-title":"Effect of the polyacrylamide ferrogel elasticity on the cell adhesiveness to magnetic composite","volume":"18","author":"Blyakhman","year":"2018","journal-title":"J. Mech. Med. Boil."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Blyakhman, F.A., Makarova, E.B., Fadeyev, F.A., Lugovets, D.V., Safronov, A.P., Shabadrov, P.A., Shklyar, T.F., Melnikov, G.Y., Orue, I., and Kurlyandskaya, G.V. (2019). The Contribution of Magnetic Nanoparticles to Ferrogel Biophysical Properties. Nanomaterials, 9.","DOI":"10.3390\/nano9020232"},{"key":"ref_12","first-page":"172","article-title":"The effect of magnetic nanoparticles on the acoustic properties of tissue mimicking agar-gel phantoms","volume":"431","author":"Kaczmarek","year":"2016","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kaczmarek, K., Hornowski, T., Dobosz, B., and J\u00f3zefczak, A. (2018). Influence of magnetic nanoparticles on the focused ultrasound hyperthermia. Materials, 11.","DOI":"10.3390\/ma11091607"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jmmm.2017.11.032","article-title":"Novel applications of magnetic materials and technologies for medicine","volume":"459","author":"Zverev","year":"2018","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/gels1010069","article-title":"Composite chitosan\/agarose ferrogels for potential applications in magnetic hyperthermia","volume":"1","author":"Soares","year":"2015","journal-title":"Gels"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115045","DOI":"10.1016\/j.carbpol.2019.115045","article-title":"Controlling the porous structure of alginate ferrogel for anticancer drug delivery under magnetic stimulation","volume":"223","author":"Kim","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1021\/la060371e","article-title":"Magnetic-sensitive behaviour of intelligent ferrogels for controlled release of drug","volume":"22","author":"Liu","year":"2006","journal-title":"Langmuir"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1063\/PT.3.1678","article-title":"Nanotechnology in cancer medicine","volume":"65","author":"Grossman","year":"2012","journal-title":"Phys. Today"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"052135","DOI":"10.1063\/1.4808368","article-title":"Spherical magnetic nanoparticles fabricated by laser target evaporation","volume":"3","author":"Safronov","year":"2013","journal-title":"AIP Adv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jmmm.2014.11.016","article-title":"Magnetic nanoparticles for biophysical applications synthesized by high-power physical dispersion","volume":"383","author":"Safronov","year":"2015","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.colsurfa.2017.12.011","article-title":"Improved magneto-viscoelasticity of cross-linked PVA hydrogels using magnetic nanoparticles","volume":"539","author":"Noorjahan","year":"2018","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"N475","DOI":"10.1088\/0031-9155\/52\/20\/N02","article-title":"Acoustical properties of selected tissue phantom materials for ultrasound imaging","volume":"52","author":"Zell","year":"2007","journal-title":"Phys. Med. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.ultrasmedbio.2005.06.004","article-title":"Gel phantom for use in high-intensity focused ultrasound dosimetry","volume":"31","author":"Lafon","year":"2005","journal-title":"Ultrasound Med. Boil."},{"key":"ref_24","first-page":"223","article-title":"Ultrasound Speed of Polymer Gel Mimicked Human Soft Tissue within Three Weeks","volume":"1","author":"Othman","year":"2011","journal-title":"Int. J. Biosci. Biochem. Bioinform."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0301-5629(03)00979-7","article-title":"Polyacrylamide gel as an acoustic coupling medium for focused ultrasound therapy","volume":"29","author":"Vaezy","year":"2003","journal-title":"Ultrasound Med. Biol."},{"key":"ref_26","unstructured":"Landau, L., and Lifshitz, E. (1987). Fluid Mechanics, Pergamon Press."},{"key":"ref_27","unstructured":"Christensen, R.M. (1991). Mechanics of Composite Materials, Krieger Publishing Company."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jmmm.2016.02.004","article-title":"Flexible thin film magnetoimpedance sensors","volume":"415","author":"Kurlyandskaya","year":"2016","journal-title":"J. Magn. Magn. Mater."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/19\/18\/3959\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:19:54Z","timestamp":1760188794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/19\/18\/3959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,13]]},"references-count":28,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["s19183959"],"URL":"https:\/\/doi.org\/10.3390\/s19183959","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,13]]}}}