{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:46:39Z","timestamp":1760240799942,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National key research and development program-Development Project of major scientific instruments and equipment","award":["2018YFF0109600"],"award-info":[{"award-number":["2018YFF0109600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper, a full depth 2D CS-SDOCT approach is proposed, which combines two-dimensional (2D) compressive sensing spectral-domain optical coherence tomography (CS-SDOCT) and dispersion encoding (ED) technologies, and its applications in structural imaging and functional sensing of bio-tissues are studied. Specifically, by introducing a large dispersion mismatch between the reference arm and sample arm in SD-OCT system, the reconstruction of the under-sampled A-scan data and the removal of the conjugated images can be achieved simultaneously by only two iterations. The under-sampled B-scan data is then reconstructed using the classic CS reconstruction algorithm. For a 5 mm \u00d7 3.2 mm fish-eye image, the conjugated image was reduced by 31.4 dB using 50% \u00d7 50% sampled data (250 depth scans and 480 spectral sampling points per depth scan), and all A-scan data was reconstructed in only 1.2 s. In addition, we analyze the application performance of the CS-SDOCT in functional sensing of locally homogeneous tissue. Simulation and experimental results show that this method can correctly reconstruct the extinction coefficient spectrum under reasonable iteration times. When 8 iterations were used to reconstruct the A-scan data in the imaging experiment of fisheye, the extinction coefficient spectrum calculated using 50% \u00d7 50% data was approximately consistent with that obtained with 100% data.<\/jats:p>","DOI":"10.3390\/s19194208","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T11:14:35Z","timestamp":1569582875000},"page":"4208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural and Functional Sensing of Bio-Tissues Based on Compressive Sensing Spectral Domain Optical Coherence Tomography"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6542-8425","authenticated-orcid":false,"given":"Luying","family":"Yi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Precision Measurement Technology &amp; Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China"}]},{"given":"Xiangyu","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision Measurement Technology &amp; Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China"}]},{"given":"Liqun","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision Measurement Technology &amp; Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-0716","authenticated-orcid":false,"given":"Bo","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision Measurement Technology &amp; Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0030-4018(95)00119-S","article-title":"Measurement of intraocular distances by backscattering spectral interferometry","volume":"117","author":"Fercher","year":"1995","journal-title":"Opt. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1364\/OE.11.000889","article-title":"Performance of Fourier domain vs. time domain optical coherence tomography","volume":"11","author":"Leitgeb","year":"2003","journal-title":"Opt. Express"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1364\/BOE.8.003248","article-title":"Twenty-five years of optical coherence tomography: The paradigm shift in sensitivity and speed provided by Fourier domain OCT","volume":"8","author":"Leitgeb","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1364\/BOE.8.000593","article-title":"Qualitative and quantitative evaluation of in vivo SD-OCT measurement of rat brain","volume":"8","author":"Xie","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1364\/BOE.6.001429","article-title":"Quantitative microvascular hemoglobin mapping using visible light spectroscopic Optical Coherence Tomography","volume":"6","author":"Chong","year":"2015","journal-title":"Biomed. Opt. Express"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1364\/OL.37.004443","article-title":"Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography","volume":"37","author":"Ji","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1364\/OE.17.004842","article-title":"Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera","volume":"17","author":"Ireneusz","year":"2009","journal-title":"Opt. Express"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"22010","DOI":"10.1364\/OE.18.022010","article-title":"Compressive SD-OCT: The application of compressed sensing in spectral domain optical coherence tomography","volume":"18","author":"Xuan","year":"2010","journal-title":"Opt. Express"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1364\/OL.37.004209","article-title":"Modified compressive sensing optical coherence tomography with noise reduction","volume":"37","author":"Daguang","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_11","first-page":"3800109","article-title":"Noise Reduction of Swept Source Optical Coherence Tomography via Compressed Sensing","volume":"10","author":"Luo","year":"2017","journal-title":"IEEE Photonics J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"14871","DOI":"10.1364\/OE.22.014871","article-title":"GPU-accelerated non-uniform fast Fourier transform-based compressive sensing spectral domain optical coherence tomography","volume":"22","author":"Daguang","year":"2014","journal-title":"Opt. Express"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1364\/BOE.3.000927","article-title":"Sparsity based denoising of spectral domain optical coherence tomography images","volume":"3","author":"Fang","year":"2012","journal-title":"Biomed. Opt. Express"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1364\/BOE.5.003921","article-title":"Volumetric (3D) compressive sensing spectral domain optical coherence tomography","volume":"5","author":"Xu","year":"2014","journal-title":"Biomed. Opt. Express"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Xu, D., Huang, Y., and Kang, J.U. (2015). Two-dimensional compressive sensing in spectral domain optical coherence tomography. SPIE BIOS, 93301A.","DOI":"10.1117\/12.2079398"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1109\/TSP.2009.2016892","article-title":"Sparse reconstruction by separable approximation","volume":"57","author":"Wright","year":"2009","journal-title":"IEEE Trans. Signal Process."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1364\/OL.27.001415","article-title":"Full range complex spectral optical coherence tomography technique in eye imaging","volume":"27","author":"Wojtkowski","year":"2002","journal-title":"Opt. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1364\/AO.56.000470","article-title":"Single-camera full-range high-resolution spectral domain optical coherence tomography","volume":"56","author":"Bo","year":"2017","journal-title":"Appl. Opt."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1364\/OE.18.004898","article-title":"Fast dispersion encoded full range optical coherence tomography for retinal imaging at 800 nm and 1060 nm","volume":"18","author":"Hofer","year":"2010","journal-title":"Opt. Express"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11335","DOI":"10.1364\/OE.17.011335","article-title":"Single-shot two-dimensional full-range optical coherence tomography achieved by dispersion control","volume":"17","author":"Witte","year":"2009","journal-title":"Opt. Express"},{"key":"ref_21","first-page":"24925","article-title":"An advanced algorithm for dispersion encoded full range frequency domain optical coherence tomography","volume":"20","author":"Cimalla","year":"2013","journal-title":"Opt. Express"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1364\/BOE.9.005071","article-title":"Full-depth spectral domain optical coherence tomography technology insensitive to phase disturbance","volume":"9","author":"Yi","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8270","DOI":"10.1364\/OE.20.008270","article-title":"Computation time-saving mirror image suppression method in Fourier-domain optical coherence tomography","volume":"20","author":"Wu","year":"2012","journal-title":"Opt. Express"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1364\/OL.42.000506","article-title":"Spatial convolution for mirror image suppression in Fourier domain optical coherence tomography","volume":"42","author":"Zhang","year":"2017","journal-title":"Opt. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1364\/AO.45.001861","article-title":"Simultaneous B-M-mode scanning method for real-time full-range Fourier domain optical coherence tomography","volume":"45","author":"Yasuno","year":"2006","journal-title":"Appl. Opt."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9316","DOI":"10.1364\/AO.57.009316","article-title":"Full-depth compressive sensing spectral-domain optical coherence tomography based on a compressive dispersion encoding method","volume":"57","author":"Yi","year":"2018","journal-title":"Appl. Opt."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1364\/OL.38.001796","article-title":"Visible-light optical coherence tomography for retinal oximetry","volume":"38","author":"Yi","year":"2013","journal-title":"Opt. Lett."},{"key":"ref_28","first-page":"743","article-title":"Automated segmentation by pixel classification of retinal layers in ophthalmic OCT images","volume":"2","author":"Lemij","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1364\/BOE.4.002570","article-title":"Quantitative comparison of analysis methods for spectroscopic optical coherence tomography","volume":"4","author":"Nienke","year":"2013","journal-title":"Biomed. Opt. Express"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1364\/BOE.5.000322","article-title":"Depth-resolved model-based reconstruction of attenuation coefficients in optical coherence tomography","volume":"5","author":"Vermeer","year":"2013","journal-title":"Biomed. Opt. Express"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10103-013-1446-7","article-title":"A literature review and novel theoretical approach on the optical properties of whole blood","volume":"29","author":"Bosschaart","year":"2014","journal-title":"Lasers Med. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9170","DOI":"10.1038\/s41598-018-27388-z","article-title":"All-depth dispersion cancellation in spectral domain optical coherence tomography using numerical intensity correlations","volume":"8","author":"Jensen","year":"2018","journal-title":"Sci. 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