{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:22:46Z","timestamp":1772158966572,"version":"3.50.1"},"reference-count":140,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Basic Research Program of China (973 Program)","award":["2015CB352101"],"award-info":[{"award-number":["2015CB352101"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571004, 31661143030"],"award-info":[{"award-number":["31571004, 31661143030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2018QNA5018, 2018FZA5018"],"award-info":[{"award-number":["2018QNA5018, 2018FZA5018"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010896","name":"International Cooperation and Exchange Programme","doi-asserted-by":"publisher","award":["8171101322 (NSFC-RFBR)"],"award-info":[{"award-number":["8171101322 (NSFC-RFBR)"]}],"id":[{"id":"10.13039\/501100010896","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Research and Development Project of Zhejiang Province","award":["2017C03032, 2019C03066"],"award-info":[{"award-number":["2017C03032, 2019C03066"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A light-addressable potentiometric sensor (LAPS) is a semiconductor electrochemical sensor based on the field-effect which detects the variation of the Nernst potential on the sensor surface, and the measurement area is defined by illumination. Thanks to its light-addressability feature, an LAPS-based chemical imaging sensor system can be developed, which can visualize the two-dimensional distribution of chemical species on the sensor surface. This sensor system has been used for the analysis of reactions and diffusions in various biochemical samples. In this review, the LAPS system set-up, including the sensor construction, sensing and substrate materials, modulated light and various measurement modes of the sensor systems are described. The recently developed technologies and the affecting factors, especially regarding the spatial resolution and temporal resolution are discussed and summarized, and the advantages and limitations of these technologies are illustrated. Finally, the further applications of LAPS-based chemical imaging sensors are discussed, where the combination with microfluidic devices is promising.<\/jats:p>","DOI":"10.3390\/s19194294","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:12:52Z","timestamp":1570162372000},"page":"4294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)"],"prefix":"10.3390","volume":"19","author":[{"given":"Tao","family":"Liang","sequence":"first","affiliation":[{"name":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"},{"name":"State Key Laboratory of Transducer Technology, Shanghai 200050, China"}]},{"given":"Yong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"}]},{"given":"Ying","family":"Gan","sequence":"additional","affiliation":[{"name":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"}]},{"given":"Jiadi","family":"Sun","sequence":"additional","affiliation":[{"name":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"}]},{"given":"Shuqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"}]},{"given":"Hao","family":"Wan","sequence":"additional","affiliation":[{"name":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"},{"name":"State Key Laboratory of Transducer Technology, Shanghai 200050, China"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China"},{"name":"State Key Laboratory of Transducer Technology, Shanghai 200050, China"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.3375810","article-title":"Light-addressable potentiometric sensor for biochemical systems","volume":"240","author":"Hafeman","year":"1988","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1126\/science.1329199","article-title":"The cytosensor microphysiometer: Biological applications of silicon technology","volume":"257","author":"McConnell","year":"1992","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.bb.23.060194.000511","article-title":"The light-addressable potentiometric sensor: Principles and biological applications","volume":"23","author":"Owicki","year":"1994","journal-title":"Annu. 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