{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:30:28Z","timestamp":1761391828605,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81627805, 61805102"],"award-info":[{"award-number":["81627805, 61805102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017607","name":"Shenzhen Basic Research Project","doi-asserted-by":"publisher","award":["JCYJ20160329150236426, JCYJ20170413140519030"],"award-info":[{"award-number":["JCYJ20160329150236426, JCYJ20170413140519030"]}],"id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Grants Council of the Hong Kong Special Administrative Region","award":["21205016, 11215817, 11101618"],"award-info":[{"award-number":["21205016, 11215817, 11101618"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21618319"],"award-info":[{"award-number":["21618319"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Optical resolution photoacoustic microscopy (OR-PAM) provides high-resolution, label-free and non-invasive functional imaging for broad biomedical applications. Dual-polarized fiber laser sensors have high sensitivity, low noise, a miniature size, and excellent stability; thus, they have been used in acoustic detection in OR-PAM. Here, we review recent progress in fiber-laser-based ultrasound sensors for photoacoustic microscopy, especially the dual-polarized fiber laser sensor with high sensitivity. The principle, characterization and sensitivity optimization of this type of sensor are presented. In vivo experiments demonstrate its excellent performance in the detection of photoacoustic (PA) signals in OR-PAM. This review summarizes representative applications of fiber laser sensors in OR-PAM and discusses their further improvements.<\/jats:p>","DOI":"10.3390\/s19214632","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T04:41:27Z","timestamp":1571978487000},"page":"4632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dual-Polarized Fiber Laser Sensor for Photoacoustic Microscopy"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7615-073X","authenticated-orcid":false,"given":"Xiangwei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon 999077, Hong Kong, China"},{"name":"City University of Hong Kong Shenzhen Research Institute, Yuexing Yi Dao, Nanshan District, Shenzhen 518057, China"}]},{"given":"Yizhi","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-0740","authenticated-orcid":false,"given":"Lidai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon 999077, Hong Kong, China"},{"name":"City University of Hong Kong Shenzhen Research Institute, Yuexing Yi Dao, Nanshan District, Shenzhen 518057, China"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nmeth.3925","article-title":"A practical guide to photoacoustic tomography in the life sciences","volume":"13","author":"Wang","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1364\/OL.39.005192","article-title":"Near-infrared optical-resolution photoacoustic microscopy","volume":"39","author":"Hai","year":"2014","journal-title":"Opt. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"094102","DOI":"10.1063\/1.4913969","article-title":"Optical-resolution photoacoustic imaging through thick tissue with a thin capillary as a dual optical-in acoustic-out waveguide","volume":"106","author":"Simandoux","year":"2015","journal-title":"Appl. Phys. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s13534-018-0060-9","article-title":"Fast photoacoustic imaging systems using pulsed laser diodes: A review","volume":"8","author":"Upputuri","year":"2018","journal-title":"Biomed. Eng. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1364\/BOE.8.002851","article-title":"Quantifying melanin concentration in retinal pigment epithelium using broadband photoacoustic microscopy","volume":"8","author":"Shu","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pacs.2016.05.001","article-title":"Photoacoustic imaging of the eye: A mini review","volume":"4","author":"Liu","year":"2016","journal-title":"Photoacoustics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroimage.2017.01.049","article-title":"Functional and oxygen-metabolic photoacoustic microscopy of the awake mouse brain","volume":"150","author":"Cao","year":"2017","journal-title":"NeuroImage"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1364\/OL.33.000929","article-title":"Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries","volume":"33","author":"Maslov","year":"2008","journal-title":"Opt. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1364\/OL.36.001134","article-title":"Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed","volume":"36","author":"Hu","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1364\/OL.36.000139","article-title":"Fast voice-coil scanning optical-resolution photoacoustic microscopy","volume":"36","author":"Wang","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nmeth.3336","article-title":"High-speed label-free functional photoacoustic microscopy of mouse brain in action","volume":"12","author":"Yao","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7932","DOI":"10.1038\/srep07932","article-title":"Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner","volume":"5","author":"Kim","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41377-018-0036-7","article-title":"Looking at sound: Optoacoustics with all-optical ultrasound detection","volume":"7","author":"Wissmeyer","year":"2018","journal-title":"Light Sci. Appl."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"174301","DOI":"10.1103\/PhysRevLett.113.174301","article-title":"Grueneisen relaxation photoacoustic microscopy","volume":"113","author":"Wang","year":"2014","journal-title":"Phys. Rev. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9027","DOI":"10.1364\/OE.19.009027","article-title":"Pure optical photoacoustic microscopy","volume":"19","author":"Xie","year":"2011","journal-title":"Opt. Express"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.3390\/s130607345","article-title":"Optoacoustic imaging and tomography: Reconstruction approaches and outstanding challenges in image performance and quantification","volume":"13","author":"Lutzweiler","year":"2013","journal-title":"Sensors"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"73507","DOI":"10.1063\/1.2771058","article-title":"Broadband all-optical ultrasound transducer","volume":"91","author":"Hou","year":"2007","journal-title":"Appl. Phys. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1364\/OPTICA.2.000169","article-title":"Isometric multimodal photoacoustic microscopy based on optically transparent micro-ring ultrasonic detection","volume":"2","author":"Dong","year":"2015","journal-title":"Optica"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41566-017-0027-x","article-title":"Ultrasensitive plano-concave optical microresonators for ultrasound sensing","volume":"11","author":"Guggenheim","year":"2017","journal-title":"Nat. Photonics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1364\/AO.47.000561","article-title":"Backward-mode multiwavelength photoacoustic scanner using a planar Fabry Perot polymer film ultrasound sensor for high-resolution three dimensional imaging of biological tissues","volume":"47","author":"Zhang","year":"2008","journal-title":"Appl. Opt."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Chitnis, P.V., Lloyd, H., and Silverman, R.H. (2014, January 3\u20136). An adaptive interferometric sensor for all-optical photoacoustic microscopy. Proceedings of the 2014 IEEE International Ultrasonics Symposium (IUS), Chicago, IL, USA.","DOI":"10.1109\/ULTSYM.2014.0087"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1364\/OPTICA.4.001180","article-title":"Fiber interferometer for hybrid optical and optoacoustic intravital microscopy","volume":"4","author":"Shnaiderman","year":"2017","journal-title":"Optica"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e16278","DOI":"10.1038\/lsa.2016.278","article-title":"Non-interferometric photoacoustic remote sensing microscopy","volume":"6","author":"Hajireza","year":"2017","journal-title":"Light Sci. Appl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1364\/OL.36.004107","article-title":"Label-free in vivo fiber-based optical-resolution photoacoustic microscopy","volume":"36","author":"Hajireza","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1109\/TUFFC.2008.870","article-title":"Characterization of a broadband all-optical ultrasound transducer-from optical and acoustical properties to imaging","volume":"55","author":"Hou","year":"2008","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1364\/OL.41.001953","article-title":"All-optical optoacoustic microscope based on wideband pulse interferometry","volume":"41","author":"Wissmeyer","year":"2016","journal-title":"Opt. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1364\/OL.36.003975","article-title":"Noncontact photoacoustic imaging achieved by using a low-coherence interferometer as the acoustic detector","volume":"36","author":"Wang","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1364\/BOE.4.002322","article-title":"Non-contact photoacoustic imaging using a fiber-based interferometer with optical amplification","volume":"4","author":"Hochreiner","year":"2013","journal-title":"Biomed. Opt. Express"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1364\/BOE.9.000650","article-title":"Large area laser scanning optical resolution photoacoustic microscopy using a fibre optic sensor","volume":"9","author":"Allen","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1364\/OL.36.001833","article-title":"High-sensitivity compact ultrasonic detector based on a pi-phase-shifted fiber Bragg grating","volume":"36","author":"Rosenthal","year":"2011","journal-title":"Opt. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/lpor.201300204","article-title":"Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications","volume":"8","author":"Rosenthal","year":"2014","journal-title":"Laser Photonics Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pacs.2014.04.002","article-title":"Sensitivity of photoacoustic microscopy","volume":"2","author":"Yao","year":"2014","journal-title":"Photoacoustics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1109\/2944.796320","article-title":"Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors","volume":"5","author":"Esenaliev","year":"1999","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"097003","DOI":"10.1117\/1.JBO.18.9.097003","article-title":"Noise-equivalent sensitivity of photoacoustics","volume":"18","author":"Winkler","year":"2013","journal-title":"J. Biomed. Opt."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1118\/1.3077120","article-title":"Sensitivity of molecular target detection by multispectral optoacoustic tomography (MSOT)","volume":"36","author":"Razansky","year":"2009","journal-title":"Med. Phys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pacs.2013.08.003","article-title":"High frequency label-free photoacoustic microscopy of single cells","volume":"1","author":"Strohm","year":"2013","journal-title":"Photoacoustics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"066011","DOI":"10.1117\/1.JBO.17.6.066011","article-title":"Quantitative photoacoustic microscopy of optical absorption coefficients from acoustic spectra in the optical diffusive regime","volume":"17","author":"Guo","year":"2012","journal-title":"J. Biomed. Opt."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jbio.201300059","article-title":"Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy","volume":"7","author":"Shelton","year":"2014","journal-title":"J. Biophotonics"},{"key":"ref_39","first-page":"131","article-title":"Compact optical-resolution photoacoustic microscopy system based on a pulsed laser diode","volume":"10","author":"Zeng","year":"2014","journal-title":"Chin. J. Lasers"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1364\/OL.37.004263","article-title":"Miniaturized all-optical photoacoustic microscopy based on microelectromechanical systems mirror scanning","volume":"37","author":"Chen","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1364\/OE.26.004271","article-title":"Large-field-of-view optical resolution photoacoustic microscopy","volume":"26","author":"Qin","year":"2018","journal-title":"Opt. Express"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1364\/OL.38.005236","article-title":"Wide-field two-dimensional multifocal optical-resolution photoacoustic-computed microscopy","volume":"38","author":"Xia","year":"2013","journal-title":"Opt. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"40849","DOI":"10.1038\/srep40849","article-title":"Fiber-laser-based ultrasound sensor for photoacoustic imaging","volume":"7","author":"Liang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1364\/BOE.9.005809","article-title":"Fast-scanning photoacoustic microscopy with a side-looking fiber optic ultrasound sensor","volume":"9","author":"Liang","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17616","DOI":"10.1364\/OE.25.017616","article-title":"Sensitivity characteristics of broadband fiber-laser-based ultrasound sensors for photoacoustic microscopy","volume":"25","author":"Bai","year":"2017","journal-title":"Opt. Express"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1364\/OL.44.002665","article-title":"Noise-reduced optical ultrasound sensor via signal duplication for photoacoustic microscopy","volume":"44","author":"Liang","year":"2019","journal-title":"Opt. Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1109\/JSEN.2009.2032153","article-title":"Single-mode birefringent fiber frequency-modulated continuous- wave interferometric strain sensor","volume":"10","author":"Zheng","year":"2010","journal-title":"IEEE Sens. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1109\/JPHOT.2011.2171480","article-title":"Noise floor reduction of an Er: Fiber laser-based photonic microwave generator","volume":"3","author":"Jiang","year":"2011","journal-title":"IEEE Photonics J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1109\/TMTT.2007.904057","article-title":"Cascaded noise penalty for amplified long-haul analog fiber-optic links","volume":"55","author":"Devgan","year":"2007","journal-title":"IEEE. Trans. Microw. Theory Tech."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1109\/3.845719","article-title":"Polarization characteristics of fiber DFB lasers related to sensing applications","volume":"36","author":"Ronnekleiv","year":"2000","journal-title":"IEEE J. Quantum Electron."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1364\/AO.39.000972","article-title":"Polarization effects in a high-birefringence elliptical fiber laser with a Bragg grating in a low-birefringence fiber","volume":"39","author":"Kozlov","year":"2000","journal-title":"Appl. Opt."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1109\/JQE.2004.830200","article-title":"Spatial mode structure of the distributed feedback fiber laser","volume":"40","author":"Foster","year":"2004","journal-title":"IEEE J. Quantum Electron."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/19\/21\/4632\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:29:08Z","timestamp":1760189348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/19\/21\/4632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,24]]},"references-count":52,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["s19214632"],"URL":"https:\/\/doi.org\/10.3390\/s19214632","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2019,10,24]]}}}