{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T11:57:41Z","timestamp":1763035061878,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Even if the first published article on a porous silicon (PSi)-based biosensor dates back to more than twenty years ago, this technology still attracts great attention from many research groups around the world. In this brief review, the pros and cons of porous silicon-based optical biosensors will be highlighted on the basis of some recent results and published papers on this subject. The aim of the paper is to give a straightforward introduction to PhD students and young researchers on this subject, which is particularly full of educative content, since it is highly multidisciplinary. Fabrication of PSi-based optical biosensors requires competencies related to many different scientific topics ranging from material science, physics and optics to healthcare and environmental monitoring through surface chemistry and more.<\/jats:p>","DOI":"10.3390\/s19214776","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T04:13:08Z","timestamp":1572840788000},"page":"4776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Porous Silicon Optical Biosensors: Still a Promise or a Failure?"],"prefix":"10.3390","volume":"19","author":[{"given":"Luca","family":"De Stefano","sequence":"first","affiliation":[{"name":"Institute for Microelectronics and Microsystems, National Research Council, Via P. Castellino 111, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1126\/science.278.5339.840","article-title":"A porous silicon-based optical interferometric biosensor","volume":"278","author":"Lin","year":"1997","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sailor, M.J. (2012). Porous Silicon in Practice: Preparation, Characterization and Applications, John Wiley and sons. [1st ed.].","DOI":"10.1002\/9783527641901"},{"key":"ref_3","unstructured":"Michael, J. (2019, September 16). Sailor Biography. Available online: http:\/\/sailorgroup.ucsd.edu\/research\/movies.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/pssa.200306485","article-title":"Light propagation in one-dimensional porous silicon complex systems","volume":"197","author":"Oton","year":"2003","journal-title":"Phys. Status Solidi (a)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1364\/OE.14.006264","article-title":"Photonic band gaps analysis of Thue-Morse multilayers made of porous silicon","volume":"14","author":"Moretti","year":"2006","journal-title":"Opt. Express"},{"key":"ref_6","unstructured":"Ligler, F.S., and Taitt, C.R. (2011). Optical Biosensors: Today and Tomorrow, Elsevier."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Korotcenkov, G. (2015). Formation and Properties. Porous Silicon: From Formation to Application, Taylor and Fracis Group, CRC Press.","DOI":"10.1201\/b19342"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1021\/acssensors.8b00933","article-title":"Near-Infrared Silicon Photonic Crystals with High-Order Photonic Bandgaps for High-Sensitivity Chemical Analysis of Water\u2013Ethanol Mixtures","volume":"3","author":"Surdo","year":"2018","journal-title":"ACS Sens."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1038\/s41467-018-07723-8","article-title":"Layer-by-layer biofunctionalization of nanostructured porous silicon for high-sensitivity and high-selectivity label-free affinity biosensing","volume":"9","author":"Mariani","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/pssc.200674336","article-title":"Quantitative measurements of hydro-alcoholic binary mixtures by porous silicon optical microsensors","volume":"4","author":"Rotiroti","year":"2007","journal-title":"Phys. Stat. Sol. (c)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"191112","DOI":"10.1063\/1.2737391","article-title":"Periodic versus aperiodic: Enhancing the sensitivity of porous silicon based optical sensor","volume":"90","author":"Moretti","year":"2007","journal-title":"Appl. Phys. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.snb.2003.12.044","article-title":"Time-resolved sensing of chemical species in porous silicon optical microcavity","volume":"100","author":"Rendina","year":"2004","journal-title":"Sens. Actuators B"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.snb.2005.05.027","article-title":"Integrated silicon-glass opto-chemical sensors for lab-on-chip applications","volume":"114","author":"Malecki","year":"2006","journal-title":"Sens. Actuators B"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Korotcenkov, G., and Rusu, E. (2019). How to Improve the Performance of Porous Silicon-Based Gas and Vapor Sensors? Approaches and Achievements. Phys. Status Solidi A.","DOI":"10.1002\/pssa.201900348"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"014513","DOI":"10.1063\/1.3273410","article-title":"Fabrication and Characterization of a Porous Silicon Based Microarray for Label-free Optical Monitoring of Biomolecular Interactions","volume":"107","author":"Rea","year":"2010","journal-title":"J. Appl. Phys."},{"key":"ref_16","first-page":"1742","article-title":"Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotides synthesis and detection","volume":"10","author":"Rea","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.apsusc.2003.10.028","article-title":"Stabilization of porous silicon surface by thermal decomposition of acetylene","volume":"225","author":"Salonen","year":"2004","journal-title":"Appl. Surf. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lehmann, V. (2002). Electrochemistry of Silicon: Instrumentation, Science, Materials and Applications, Wiley-VCH Verlag GmbH.","DOI":"10.1002\/3527600272"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Canham, L. (2014). Handbook of Porous Silicon, Springer.","DOI":"10.1007\/978-3-319-05744-6"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1021\/la301085t","article-title":"Characterization of phospholipid bilayer formation on a thin film of porous SiO2 by reflective interferometric Fourier transform spectroscopy (RIFTS)","volume":"28","author":"Pace","year":"2012","journal-title":"Langmuir"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1703393","DOI":"10.1002\/adma.201703393","article-title":"Multifunctional nanohybrid based on porous silicon nanoparticles, gold nanoparticles, and acetalated dextran for liver regeneration and acute liver failure theranostics","volume":"30","author":"Liu","year":"2018","journal-title":"Adv. Mat."},{"key":"ref_22","first-page":"441","article-title":"Porous silicon-based photonic biosensors: Current status and emerging applications","volume":"91","author":"Segal","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Terracciano, M., Rea, I., Borbone, N., Moretta, R., Oliviero, G., Piccialli, G., and De Stefano, L. (2018). Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring. Molecules, 24.","DOI":"10.3390\/molecules24122216"},{"key":"ref_24","first-page":"49","article-title":"Recent Advances in Porous Silicon Based Optical Biosensors","volume":"53","author":"Maniya","year":"2018","journal-title":"Rec. Adv. Mater. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1002\/adfm.201502859","article-title":"Oxidized porous silicon nanostructures enabling electrokinetic transport for enhanced DNA detection","volume":"25","author":"Vilensky","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1002\/adfm.201304053","article-title":"Porous silicon resonant microcavity biosensor for matrix metalloproteinase detection","volume":"24","author":"Krismastuti","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"15174","DOI":"10.1364\/OE.18.015174","article-title":"Protease detection using a porous silicon based Bloch surface wave optical biosensor","volume":"18","author":"Qiao","year":"2010","journal-title":"Opt. Express"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/pssa.200881072","article-title":"Small molecule detection by reflective interferometric Fourier transform spectroscopy (RIFTS)","volume":"206","author":"Pacholski","year":"2009","journal-title":"Phys. Status Solidi A"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Steglich, P., H\u00fclsemann, M., Dietzel, B., and Mai, A. (2019). Optical biosensors based on silicon-on-insulator ring resonators: A review. Molecules, 24.","DOI":"10.20944\/preprints201901.0012.v1"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/14737159.2019.1554435","article-title":"Label-free plasmonic biosensors for point-of-care diagnostics: A review","volume":"19","author":"Soler","year":"2019","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111693","DOI":"10.1016\/j.bios.2019.111693","article-title":"Optical biosensors based on refractometric sensing schemes: A review","volume":"144","author":"Chen","year":"2019","journal-title":"Biosens. 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