{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:14:08Z","timestamp":1773879248182,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770724"],"award-info":[{"award-number":["31770724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A sensitive strategy to rapidly detect fipronil residues in eggs using multibranch gold nanoparticles (AuNPs) as the substrate of surface-enhanced Raman spectroscopy (SERS) was investigated in this study. Under optimized conditions, fipronil molecules preferentially deposited on the multibranch gold nanoparticles with preferential (111) facet-oriented growth due to its low surface energy. This anisotropic growth promoted the increase of SERS \u201chot spots\u201d, inducing a huge enhancement of Raman signals of the fipronil. An external standard calibration method was employed for quantitative analysis, and the method was validated for linearity, sensitivity, repeatability and recovery. Good linearity were found in the concentration range of 10 ng\/L~10 mg\/L in fipronil acetone solution (R2 = 0.9916) and 8 \u00d7 10\u22125 mg\/m2 to 0.8 mg\/m2 on eggshells (R2 = 0.9906), respectively. The recovery rate based on acetone recovered fipronil on eggshells and in egg liquids was 80.13%~87.87%, and 81.34%~88.89%, respectively. The SERS assay was successfully used to monitor fipronil in eggs.<\/jats:p>","DOI":"10.3390\/s19245354","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T03:16:36Z","timestamp":1575515796000},"page":"5354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multibranch Gold Nanoparticles as Surface-Enhanced Raman Spectroscopy Substrates for Rapid and Sensitive Analysis of Fipronil in Eggs"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5031-0531","authenticated-orcid":false,"given":"Haonuan","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Chemistry and Material Science, Shandong Agricultural University, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Material Science, Shandong Agricultural University, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-8536","authenticated-orcid":false,"given":"Shuhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Material Science, Shandong Agricultural University, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"ref_1","first-page":"e05164","article-title":"Occurrence of residues of fipronil and other acaricides in chicken eggs and poultry muscle\/fat","volume":"16","author":"Reich","year":"2018","journal-title":"EFSA J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.foodcont.2018.08.025","article-title":"A simple and rapid method for detecting the pesticide fipronil on egg shells and in liquid eggs by Raman microscopy","volume":"96","author":"Tu","year":"2019","journal-title":"Food Control"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1584\/jpestics.R07-02","article-title":"Environmental fate and toxicology of fipronil","volume":"32","author":"Gunasekara","year":"2007","journal-title":"J. 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