{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:55:46Z","timestamp":1780084546012,"version":"3.54.0"},"reference-count":83,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rede Nacional de Ensino e Pesquisa","award":["01250.075413\/2018-04"],"award-info":[{"award-number":["01250.075413\/2018-04"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["422163\/2018-0"],"award-info":[{"award-number":["422163\/2018-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305958\/2018-6"],"award-info":[{"award-number":["305958\/2018-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["429496\/2018-4"],"award-info":[{"award-number":["429496\/2018-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/14262-7"],"award-info":[{"award-number":["2013\/14262-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Detection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson\u2019s disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanospheres, AgNP; and nanoplates, AgNPL) to detect L-Dopa in the nanoparticle dispersions. The sensitivity of the L-Dopa SERS signal depended on both nanoparticle shape and L-Dopa concentration. The adsorption mechanisms of L-Dopa on the nanoparticles inferred from a detailed analysis of the Raman spectra allowed us to determine the chemical groups involved. For instance, at concentrations below\/equivalent to the limit found in human plasma (between 10\u22127\u201310\u22128 mol\/L), L-Dopa adsorbs on AgNP through its ring, while at 10\u22125\u201310\u22126 mol\/L adsorption is driven by the amino group. At even higher concentrations, above 10\u22124 mol\/L, L-Dopa polymerization predominates. Therefore, our results show that adsorption depends on both the type of Ag nanoparticles (shape and chemical groups surrounding the Ag surface) and the L-Dopa concentration. The overall strategy based on SERS is a step forward to the design of nanostructures to detect analytes of clinical interest with high specificity and at varied concentration ranges.<\/jats:p>","DOI":"10.3390\/s20010015","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:15:01Z","timestamp":1577070901000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Designing Silver Nanoparticles for Detecting Levodopa (3,4-Dihydroxyphenylalanine, L-Dopa) Using Surface-Enhanced Raman Scattering (SERS)"],"prefix":"10.3390","volume":"20","author":[{"given":"Rafael Jesus Gon\u00e7alves","family":"Rubira","sequence":"first","affiliation":[{"name":"School of Technology and Applied Sciences, S\u00e3o Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Alessio","family":"Camacho","sequence":"additional","affiliation":[{"name":"School of Sciences, Humanities and Languages, S\u00e3o Paulo State University (UNESP), Assis 19806-900 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibely Silva","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Technology and Applied Sciences, S\u00e3o Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-9957","authenticated-orcid":false,"given":"Jorge Ricardo","family":"Mej\u00eda-Salazar","sequence":"additional","affiliation":[{"name":"National Institute of Telecommunications (Inatel), Santa Rita do Sapuca\u00ed 37540-000 MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faustino","family":"Reyes G\u00f3mez","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo (USP), P.O. Box 369, S\u00e3o Carlos 13560-970 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6887-4749","authenticated-orcid":false,"given":"Robson Rosa","family":"da Silva","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo (USP), P.O. Box 369, S\u00e3o Carlos 13560-970 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo Novais de","family":"Oliveira Junior","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo (USP), P.O. Box 369, S\u00e3o Carlos 13560-970 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Alessio","sequence":"additional","affiliation":[{"name":"School of Technology and Applied Sciences, S\u00e3o Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Jos\u00e9 Leopoldo","family":"Constantino","sequence":"additional","affiliation":[{"name":"School of Technology and Applied Sciences, S\u00e3o Paulo State University (UNESP), Presidente Prudente 19060-900 SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jcis.2018.11.035","article-title":"A high-resolution study of in situ surface-enhanced Raman scattering nanotag behavior in biological systems","volume":"537","author":"Wang","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nbt977","article-title":"Homogeneous detection of unamplified genomic DNA sequences based on colorimetric scatter of gold nanoparticle probes","volume":"22","author":"Storhoff","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1007\/s12274-017-1576-5","article-title":"Diagnosis of breast cancer by analysis of sialic acid concentrations in human saliva by surface-enhanced Raman spectroscopy of silver nanoparticles","volume":"10","author":"Vinogradova","year":"2017","journal-title":"Nano Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/09205063.2019.1580664","article-title":"Functionalized photosensitive gelatin nanoparticles for drug delivery application","volume":"30","author":"Carvalho","year":"2019","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1039\/C9TB00061E","article-title":"Gold nanostars for cancer cell-targeted SERS-imaging and NIR light-triggered plasmonic photothermal therapy (PPTT) in the first and second biological windows","volume":"7","author":"Song","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1080\/00032719.2019.1586913","article-title":"Colorimetric Determination of Hydrogen Peroxide Based on Localized Surface Plasmon Resonance of Silver Nanoprisms Using a Microchannel Chip","volume":"52","author":"Lertvachirapaiboon","year":"2019","journal-title":"Anal. Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1007\/s00396-014-3332-7","article-title":"Detection of trace levels of atrazine using surface-enhanced Raman scattering and information visualization","volume":"292","author":"Rubira","year":"2014","journal-title":"Colloid Polym. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"23597","DOI":"10.1021\/acsami.5b06887","article-title":"Large-Scale Plasmonic nanoCones Array For Spectroscopy Detection","volume":"7","author":"Das","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_9","unstructured":"(2006). R Aroca Surface-Enhanced Vibrational Spectroscopy, John Wiley & Sons Ltd."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Le Ru, E.C., and Etchegoin, P.G. (2009). Principles of Surface Enhanced Raman Spectroscopy (and Related Plasmonic Effects), Elsevier.","DOI":"10.1016\/B978-0-444-52779-0.00005-2"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1039\/c3an36610c","article-title":"Microspectroscopic SERS detection of interleukin-6 with rationally designed gold\/silver nanoshells","volume":"138","author":"Wang","year":"2013","journal-title":"Analyst"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/2053-1591\/ab1fd3","article-title":"Enhancement of Raman signal from analytes on ultrathin Au and AuCu alloy nanowire network substrates","volume":"6","author":"Chatterjee","year":"2019","journal-title":"Mater. Res. Express"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1021\/acsnano.8b04073","article-title":"Gold Nanoparticle Plasmonic Superlattices as Surface-Enhanced Raman Spectroscopy Substrates","volume":"12","author":"Matricardi","year":"2018","journal-title":"ACS Nano"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11152","DOI":"10.1021\/acsami.7b19081","article-title":"Seeded Growth Synthesis of Gold Nanotriangles: Size Control, SAXS Analysis, and SERS Performance","volume":"10","author":"Kuttner","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.saa.2017.07.049","article-title":"Determination of B-complex vitamins in pharmaceutical formulations by surface-enhanced Raman spectroscopy","volume":"188","author":"Junior","year":"2018","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1007\/s10853-019-03403-0","article-title":"Controlled synthesis of multi-branched gold nanodendrites by dynamic microfluidic flow system","volume":"54","author":"Calamak","year":"2019","journal-title":"J. Mater. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.saa.2018.12.001","article-title":"The synthesis of Ag-coated tetrapod gold nanostars and the improvement of surface-enhanced Raman scattering. Spectrochim","volume":"211","author":"Zhu","year":"2019","journal-title":"Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8891","DOI":"10.1021\/la300194v","article-title":"Adsorption and Detection of Sport Doping Drugs on Metallic Plasmonic Nanoparticles of Different Morphology","volume":"28","author":"Alda","year":"2012","journal-title":"Langmuir"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1021\/jp401737y","article-title":"Silver Nanostars with High SERS Performance","volume":"117","year":"2013","journal-title":"J. Phys. Chem. C"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/ijch.201800041","article-title":"Pillar[5]arene-stabilized Plasmonic Nanoparticles as Selective SERS Sensors","volume":"58","year":"2018","journal-title":"Isr. J. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1021\/jp8101817","article-title":"Surface-Enhanced Raman Scattering: Comparison of Three Different Molecules on Single-Crystal Nanocubes and Nanospheres of Silver \u2020","volume":"113","author":"Rycenga","year":"2009","journal-title":"J. Phys. Chem. A"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jrs.3022","article-title":"Comparison of SERS effectiveness of copper substrates prepared by different methods: What are the values of enhancement factors?","volume":"43","author":"Prokopec","year":"2012","journal-title":"J. Raman Spectrosc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jrs.4874","article-title":"Why and how do the shapes of surface-enhanced Raman scattering spectra change? Recent progress from mechanistic studies","volume":"47","author":"Yamamoto","year":"2016","journal-title":"J. Raman Spectrosc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/la0115684","article-title":"Patterning of Organic Monolayers on Silver via Surface-Induced Photoreaction","volume":"18","author":"Han","year":"2002","journal-title":"Langmuir"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1039\/c2cp40558j","article-title":"Surface-enhanced Raman spectroscopic study of p-aminothiophenol","volume":"14","author":"Huang","year":"2012","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11467-013-0347-3","article-title":"Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering (SERS) and basic applications of SERS biological sensing","volume":"9","author":"Yamamoto","year":"2014","journal-title":"Front. Phys."},{"key":"ref_27","first-page":"1021","article-title":"Erratum: Second enhancement in surface-enhanced resonance Raman scattering revealed by an analysis of anti-Stokes and Stokes Raman spectra","volume":"76","author":"Itoh","year":"2007","journal-title":"Phys. Rev. B"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"01","DOI":"10.1103\/PhysRevB.79.085419","article-title":"Experimental evaluation of the twofold electromagnetic enhancement theory of surface-enhanced resonance Raman scattering","volume":"79","author":"Yoshida","year":"2009","journal-title":"Phys. Rev. B"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1103\/RevModPhys.57.783","article-title":"Surface-enhanced spectroscopy","volume":"57","author":"Moskovits","year":"1985","journal-title":"Rev. Mod. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.molstruc.2013.02.025","article-title":"Raman and SERS study on atrazine, prometryn and simetryn triazine herbicides","volume":"1040","author":"Bonora","year":"2013","journal-title":"J. Mol. Struct."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1021\/la010489p","article-title":"Surface Orientation of Pyrazine Adsorbed on Silver from the Surface-Enhanced Raman Scattering Recorded at Different Electrode Potentials","volume":"18","author":"Soto","year":"2002","journal-title":"Langmuir"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1039\/b903823j","article-title":"Surface-enhanced Raman scattering of 5-fluorouracil adsorbed on silver nanostructures","volume":"11","author":"Sardo","year":"2009","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/jrs.2135","article-title":"Silver nanoparticles synthesized by direct photoreduction of metal salts. Application in surface-enhanced Raman spectroscopy","volume":"40","author":"Saniger","year":"2009","journal-title":"J. Raman Spectrosc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cplett.2007.07.106","article-title":"Non-resonance SERS effects of silver colloids with different shapes","volume":"446","author":"Tiwari","year":"2007","journal-title":"Chem. Phys. Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1021\/jp310619c","article-title":"Adsorption and Detection of Amyloid Marker Thioflavin T on Ag Nanoparticles by Surface-Enhanced Raman Scattering","volume":"117","author":"Antalik","year":"2013","journal-title":"J. Phys. Chem. C"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/jrs.4737","article-title":"Detection and quantitative analysis of carbendazim herbicide on Ag nanoparticles via surface-enhanced Raman scattering","volume":"46","author":"Furini","year":"2015","journal-title":"J. Raman Spectrosc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1039\/C8AN01845F","article-title":"A simple approach for the ultrasensitive detection of paraquat residue in adzuki beans by surface-enhanced Raman scattering","volume":"144","author":"Tsen","year":"2019","journal-title":"Analyst"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/ac8021746","article-title":"Nanosensors Based on Viologen Functionalized Silver Nanoparticles: Few Molecules Surface-Enhanced Raman Spectroscopy Detection of Polycyclic Aromatic Hydrocarbons in Interparticle Hot Spots","volume":"81","author":"Guerrini","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.molstruc.2004.02.034","article-title":"Combination of high-performance liquid chromatography and SERS detection applied to the analysis of drugs in human blood and urine","volume":"693","author":"Trachta","year":"2004","journal-title":"J. Mol. Struct."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.biopha.2007.10.018","article-title":"Simultaneous determination of serum concentrations of levodopa, dopamine, 3-O-methyldopa and \u03b1-methyldopa by HPLC","volume":"62","author":"Muzzi","year":"2008","journal-title":"Biomed. Pharmacother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.1164901","article-title":"Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson\u2019s Disease","volume":"323","author":"Fuentes","year":"2009","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-4347(91)80366-K","article-title":"Determination of l-3,4-dihydroxyphenylalanine in biological fluids and tissues","volume":"565","author":"Dizdar","year":"1991","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.bios.2010.01.033","article-title":"Mushroom tyrosinase in polyelectrolyte multilayers as an optical biosensor for o-diphenols","volume":"25","author":"Fiorentino","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.snb.2016.12.059","article-title":"Simple and rapid detection of l-dopa based on in situ formation of polylevodopa nanoparticles","volume":"243","author":"Moslehipour","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/elan.200403343","article-title":"Amperometric Flow-Injection Determination of Phenolic Compounds Using a Biosensor with Immobilized Laccase, Peroxidase and Tyrosinase","volume":"17","year":"2005","journal-title":"Electroanalysis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.electacta.2012.11.121","article-title":"Nanomolar simultaneous determination of levodopa and serotonin at a novel carbon ionic liquid electrode modified with Co(OH)2 nanoparticles and multi-walled carbon nanotubes","volume":"90","author":"Babaei","year":"2013","journal-title":"Electrochim. Acta"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jelechem.2009.09.010","article-title":"Electrochemical determination of l-dopa in the presence of ascorbic acid on the surface of the glassy carbon electrode modified by a bilayer of multi-walled carbon nanotube and poly-pyrrole doped with tiron","volume":"636","author":"Shahrokhian","year":"2009","journal-title":"J. Electroanal. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1039\/C5AY03041B","article-title":"Electrochemical sensing of levodopa or carbidopa using a glassy carbon electrode modified with carbon nanotubes within a poly(allylamine hydrochloride) film","volume":"8","author":"Takeda","year":"2016","journal-title":"Anal. Methods"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1021\/ac00156a014","article-title":"Surface-enhanced Raman spectroscopy of the catecholamine neurotransmitters and related compounds","volume":"60","author":"Lee","year":"1988","journal-title":"Anal. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0584-8539(94)00235-4","article-title":"Near-infrared surface-enhanced Raman scattering (NIR-SERS) of neurotransmitters in colloidal silver solutions. Spectrochim","volume":"51","author":"Kneipp","year":"1995","journal-title":"Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_51","first-page":"1921","article-title":"Ultrasensitive detection of neurotransmitters by surface enhanced Raman spectroscopy for biosensing applications","volume":"7","author":"Qiu","year":"2017","journal-title":"Biointerface Res. Appl. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1166\/jnn.2013.7644","article-title":"Optical Properties of Dopamine Molecules with Silver Nanoparticles as Surface-Enhanced Raman Scattering (SERS) Substrates at Different pH Conditions","volume":"13","author":"Bu","year":"2013","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gomez, F.R., Rubira, R.J.G., Camacho, S.A., Martin, C.S., da Silva, R.R., Constantino, C.J.L., Alessio, P., Oliveira, O.N., and Mej\u00eda-Salazar, J.R. (2018). Surface Plasmon Resonances in Silver Nanostars. Sensors, 18.","DOI":"10.3390\/s18113821"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1021\/jp027460u","article-title":"A New Method for Fast Preparation of Highly Surface-Enhanced Raman Scattering (SERS) Active Silver Colloids at Room Temperature by Reduction of Silver Nitrate with Hydroxylamine Hydrochloride","volume":"107","author":"Leopold","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Cathcart, N., Frank, A.J., and Kitaev, V. (2009). Silver nanoparticles with planar twinned defects: Effect of halides for precise tuning of plasmon resonance maxima from 400 to > 900 nm. Chem. Commun., 7170\u20137172.","DOI":"10.1039\/b916902d"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Minghim, R., Paulovich, F.V., and Andrade Lopes, A. (2006, January 15). Content-based text mapping using multi-dimensional projections for exploration of document collections. Proceedings of the Visualization and Data Analysis 2006, San Jose, CA, USA.","DOI":"10.1117\/12.650880"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8546","DOI":"10.1021\/la050030l","article-title":"Comparative study of the morphology, aggregation, adherence to glass, and surface-enhanced Raman scattering activity of silver nanoparticles prepared by chemical reduction of Ag+ using citrate and hydroxylamine","volume":"21","author":"Canamares","year":"2005","journal-title":"Langmuir"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/adfm.200800233","article-title":"Optical Properties and Growth Aspects of Silver Nanoprisms Produced by a Highly Reproducible and Rapid Synthesis at Room Temperature","volume":"18","author":"Aherne","year":"2008","journal-title":"Adv. Funct. Mater."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1039\/c2dt90061k","article-title":"Application of inorganic chemistry for non-cancer therapeutics","volume":"41","author":"Franz","year":"2012","journal-title":"Dalt. Trans."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1364\/OE.20.000621","article-title":"Gold nanostars as thermoplasmonic nanoparticles for optical heating","volume":"20","year":"2012","journal-title":"Opt. Express"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1364\/OE.18.000843","article-title":"A numerical investigation of the effect of vertex geometry on localized surface plasmon resonance of nanostructures","volume":"18","author":"Ma","year":"2010","journal-title":"Opt. Express"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1126\/science.1066541","article-title":"Photoinduced Conversion of Silver Nanospheres to Nanoprisms","volume":"294","author":"Jin","year":"2001","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/35104560","article-title":"Induction of gadd45\u03b2 by NF-\u03baB downregulates pro-apoptotic JNK signalling","volume":"414","author":"Zazzeroni","year":"2001","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1039\/C1NR11297J","article-title":"Strategies in biomimetic surface engineering of nanoparticles for biomedical applications","volume":"4","author":"Gong","year":"2012","journal-title":"Nanoscale"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature02020","article-title":"Controlling anisotropic nanoparticle growth through plasmon excitation","volume":"425","author":"Jin","year":"2003","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1021\/ja809418t","article-title":"Zeptomol Detection Through Controlled Ultrasensitive Surface-Enhanced Raman Scattering","volume":"131","author":"Mazzucco","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_67","unstructured":"Aroca, R.F., Vallete, M.C., Ramos, J.V.G., Cort\u00e9s, S.S., S\u00e1nchez Gil, J.A., and Sevilla, P. (2014). Amplificaci\u00f3n Plasm\u00f3nica de Espectros Raman y de Fluorescencia-SERS y SEF Sobre Nanoestructuras Met\u00e1licas, Consejo Superior de Investigaciones Cientificas. [1st ed.]."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"16448","DOI":"10.1073\/pnas.0808365105","article-title":"Managing light polarization via plasmon-molecule interactions within an asymmetric metal nanoparticle trimer","volume":"105","author":"Shegai","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1039\/C6NR01155A","article-title":"A study of the depth and size of concave cube Au nanoparticles as highly sensitive SERS probes","volume":"8","author":"Guerrini","year":"2016","journal-title":"Nanoscale"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1021\/ac902585a","article-title":"Coupling Surface-Enhanced Resonance Ram;an Scattering and Electronic Tongue as Characterization Tools to Investigate Biological Membrane Mimetic Systems","volume":"82","author":"Aoki","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1366\/000370203322005337","article-title":"Surface-Enhanced Resonance Raman Scattering: Single-Molecule Detection in a Langmuir\u2014Blodgett Monolayer","volume":"57","author":"Constantino","year":"2003","journal-title":"Appl. Spectrosc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molstruc.2012.09.004","article-title":"Vibrational spectral analysis of anti-neurodegenerative drug Levodopa: A DFT study","volume":"1034","author":"Edwin","year":"2013","journal-title":"J. Mol. Struct."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"10377","DOI":"10.1021\/acs.langmuir.6b02948","article-title":"Characterizations of the Formation of Polydopamine-Coated Halloysite Nanotubes in Various pH Environments","volume":"32","author":"Feng","year":"2016","journal-title":"Langmuir"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"19216","DOI":"10.1021\/jp205050k","article-title":"Fate of L-DOPA in the Presence of Inorganic Matrices: Vectorization or Composite Material Formation?","volume":"115","author":"Jaber","year":"2011","journal-title":"J. Phys. Chem. C"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.electacta.2009.11.022","article-title":"Electrochemical growth of flowerlike gold nanoparticles on polydopamine modified ITO glass for SERS application","volume":"55","author":"Ye","year":"2010","journal-title":"Electrochim. Acta"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"98318","DOI":"10.1039\/C5RA19098C","article-title":"Shape controlled synthesis of multi-branched gold nanocrystals through a facile one-pot bifunctional biomolecular approach","volume":"5","author":"Sajitha","year":"2015","journal-title":"RSC Adv."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1007\/s11051-014-2523-y","article-title":"Unnatural amino acid-mediated synthesis of silver nanoparticles and their antifungal activity against Candida species","volume":"16","author":"Narayanan","year":"2014","journal-title":"J. Nanoparticle Res."},{"key":"ref_78","first-page":"19","article-title":"Treatment of Parkinson\u2019s disease: Nanostructured sol-gel silica-dopamine reservoirs for controlled drug release in the central nervous system","volume":"6","author":"Lopez","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1039\/c0an00822b","article-title":"Information visualization techniques for sensing and biosensing","volume":"136","author":"Paulovich","year":"2011","journal-title":"Analyst"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13758-012-0053-7","article-title":"Information Visualization to Enhance Sensitivity and Selectivity in Biosensing","volume":"7","author":"Oliveira","year":"2012","journal-title":"Biointerphases"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1007\/s10853-015-9628-2","article-title":"Probing trace levels of prometryn solutions: From test samples in the lab toward real samples with tap water","volume":"51","author":"Rubira","year":"2016","journal-title":"J. Mater. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1021\/acssensors.7b00639","article-title":"Zika Immunoassay Based on Surface-Enhanced Raman Scattering Nanoprobes","volume":"3","author":"Camacho","year":"2018","journal-title":"ACS Sens."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1039\/c0ce00215a","article-title":"Shape dependent electrocatalytic behaviour of silver nanoparticles","volume":"12","author":"Bansal","year":"2010","journal-title":"CrystEngComm"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/1\/15\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:43:29Z","timestamp":1760190209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/1\/15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":83,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["s20010015"],"URL":"https:\/\/doi.org\/10.3390\/s20010015","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]}}}