{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:13:11Z","timestamp":1763226791504,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002358","name":"Beihang University","doi-asserted-by":"publisher","award":["ZG216S18B5"],"award-info":[{"award-number":["ZG216S18B5"]}],"id":[{"id":"10.13039\/501100002358","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qingdao Innovation and Entrepreneurship Leadership Program","award":["18-1-2-21-zhc"],"award-info":[{"award-number":["18-1-2-21-zhc"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The detection and analysis of circulating tumor cells (CTCs) plays a crucial role in clinical practice. However, the heterogeneity and rarity of CTCs make their capture and separation from peripheral blood very difficult while maintaining their structural integrity and viability. We previously demonstrated the effectiveness of the Magnetic Cell Centrifuge Platform (MCCP), which combined the magnetic-labeling cell separation mechanism with the size-based method. In this paper, a comparison of the effectiveness of different microsieve pore geometries toward MCCP is demonstrated to improve the yield of the target cell capture. Firstly, models of a trapped cell with rectangular and circular pore geometries are presented to compare the contact force using finite element numerical simulations. The device performance is then evaluated with both constant pressure and constant flow rate experimental conditions. In addition, the efficient isolation of magnetically labeled Hela cells with red fluorescent proteins (target cells) from Hela cells with green fluorescent protein (background cells) is validated. The experimental results show that the circular sieves yield 97% purity of the target cells from the sample with a throughput of up to 2 \u03bcL\/s and 66-fold sample enrichment. This finding will pave the way for the design of a higher efficient MCCP systems.<\/jats:p>","DOI":"10.3390\/s20010048","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:15:01Z","timestamp":1577070901000},"page":"48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magnetic Cell Centrifuge Platform Performance Study with Different Microsieve Pore Geometries"],"prefix":"10.3390","volume":"20","author":[{"given":"Xinyu","family":"Wu","sequence":"first","affiliation":[{"name":"School of Microelectronics, Beihang University, Beijing 100191, China"},{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]},{"given":"Zhongyang","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Beihang University, Beijing 100191, China"},{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]},{"given":"Guangchao","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Beihang University, Beijing 100191, China"},{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]},{"given":"Mengzheng","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Beihang University, Beijing 100191, China"},{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Beihang University, Beijing 100191, China"},{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]},{"given":"Bo","family":"Ma","sequence":"additional","affiliation":[{"name":"Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"}]},{"given":"Qinglin","family":"Song","sequence":"additional","affiliation":[{"name":"Qingdao Goertek Microelectronics Research Institute Co., Ltd., Qingdao 266104, China"}]},{"given":"Dewen","family":"Tian","sequence":"additional","affiliation":[{"name":"Qingdao Goertek Microelectronics Research Institute Co., Ltd., Qingdao 266104, China"}]},{"given":"Frederik","family":"Ceyssens","sequence":"additional","affiliation":[{"name":"ESAT-MICAS, KU Leuven, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3415-2275","authenticated-orcid":false,"given":"Robert","family":"Puers","sequence":"additional","affiliation":[{"name":"ESAT-MICAS, KU Leuven, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium"}]},{"given":"Michael","family":"Kraft","sequence":"additional","affiliation":[{"name":"ESAT-MICAS, KU Leuven, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium"}]},{"given":"Weisheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Beihang University, Beijing 100191, China"},{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]},{"given":"Lianggong","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Beihang University, Beijing 100191, China"},{"name":"Beihang-Goertek Joint Microelectronics Institute, Qingdao Research Institute, Beihang University, Qingdao 266104, China"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrc1670","article-title":"Breast cancer metastasis: Markers and models","volume":"5","author":"Weigelt","year":"2005","journal-title":"Nat. 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