{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:39:50Z","timestamp":1775324390584,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","award":["Chairs Program"],"award-info":[{"award-number":["Chairs Program"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Detection of thermal activities of biological cells is important for biomedical and pharmaceutical applications because these activities are closely associated with the conformational change processes. Calorimetric measurements of biological systems using bimaterial microcantilevers (BMC) have increasingly been reported with the ultimate goal of developing highly sensitive and inexpensive techniques with real-time measurement capability techniques for the characterization of dynamic thermal properties of biological cells. BMCs have been established as highly sensitive calorimeters for the thermal analysis of cells and liquids. In this paper, we present a simulation model using COMSOL Multiphysics and a mathematical method to estimate the heat capacity of objects (treated here as a biological cell) placed on the surface of a microcantilever. By measuring the thermal time constant, which is obtained from the deflection curve of a BMC, the heat capacity of a sample can be evaluated. With this model, we can estimate the heat capacity of single biological cells using a BMC, which can potentially be used for the thermal characterization of different biological samples.<\/jats:p>","DOI":"10.3390\/s20010215","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T03:28:53Z","timestamp":1578022133000},"page":"215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Modeling of an Optically Heated MEMS-Based Micromechanical Bimaterial Sensor for Heat Capacitance Measurements of Single Biological Cells"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0202-8712","authenticated-orcid":false,"given":"Abdullah","family":"Alodhayb","sequence":"first","affiliation":[{"name":"Research Chair for Tribology, Surface, and Interface Sciences, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Aramco Laboratory for Applied Sensing Research, King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 4260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0925-4005(01)00856-5","article-title":"Micromechanical cantilever-based biosensors","volume":"79","author":"Raiteri","year":"2001","journal-title":"Sens. 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