{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:16:14Z","timestamp":1778800574653,"version":"3.51.4"},"reference-count":135,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rede Nacional de Ensino e Pesquisa (RNP)","award":["01250.075413\/2018-04"],"award-info":[{"award-number":["01250.075413\/2018-04"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305958\/2018-6; 429496\/2018-4"],"award-info":[{"award-number":["305958\/2018-6; 429496\/2018-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/14262-7"],"award-info":[{"award-number":["2013\/14262-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>There has been growing interest in using strong field enhancement and light localization in plasmonic nanostructures to control the polarization properties of light. Various experimental techniques are now used to fabricate twisted metallic nanoparticles and metasurfaces, where strongly enhanced chiral near-fields are used to intensify circular dichroism (CD) signals. In this review, state-of-the-art strategies to develop such chiral plasmonic nanoparticles and metasurfaces are summarized, with emphasis on the most recent trends for the design and development of functionalizable surfaces. The major objective is to perform enantiomer selection which is relevant in pharmaceutical applications and for biosensing. Enhanced sensing capabilities are key for the design and manufacture of lab-on-a-chip devices, commonly named point-of-care biosensing devices, which are promising for next-generation healthcare systems.<\/jats:p>","DOI":"10.3390\/s20030944","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T11:45:30Z","timestamp":1581421530000},"page":"944","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Chiral Plasmonics and Their Potential for Point-of-Care Biosensing Applications"],"prefix":"10.3390","volume":"20","author":[{"given":"Willian","family":"A. Paiva-Marques","sequence":"first","affiliation":[{"name":"National Institute of Telecommunications (Inatel), Santa Rita do Sapuca\u00ed MG 37540-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faustino","family":"Reyes G\u00f3mez","sequence":"additional","affiliation":[{"name":"Sao Carlos Institute of Physics, University of Sao Paulo, PO Box 369, Sao Carlos 13560-970, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Osvaldo","family":"N. Oliveira","sequence":"additional","affiliation":[{"name":"Sao Carlos Institute of Physics, University of Sao Paulo, PO Box 369, Sao Carlos 13560-970, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1742-9957","authenticated-orcid":false,"given":"J. Ricardo","family":"Mej\u00eda-Salazar","sequence":"additional","affiliation":[{"name":"National Institute of Telecommunications (Inatel), Santa Rita do Sapuca\u00ed MG 37540-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"ref_1","first-page":"70","article-title":"Stereochemistry in Drug Action","volume":"5","author":"McConathy","year":"2013","journal-title":"Primary Care Companion J. Clin. Psychiatry"},{"key":"ref_2","first-page":"4644","article-title":"Stereochemistry and its role in drug design","volume":"5","author":"Singh","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1166\/jbn.2011.1324","article-title":"Medical Applications of Nanoparticles in Biological Imaging, Cell Labeling, Antimicrobial Agents and Anticancer Nanodrugs","volume":"7","author":"Singh","year":"2011","journal-title":"J. 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