{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:46:32Z","timestamp":1771235192759,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11674199"],"award-info":[{"award-number":["11674199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11774208"],"award-info":[{"award-number":["11774208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11804196"],"award-info":[{"award-number":["11804196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2017GGX20120"],"award-info":[{"award-number":["2017GGX20120"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017BA018"],"award-info":[{"award-number":["ZR2017BA018"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A highly sensitive Au-graphene structure D-type fiber surface plasmon resonance biosensor is presented in this study to specifically detect biomolecules. The method of growing graphene is employed directly on the copper, and then a gold film of optimum thickness is sputtered, and the copper foil is etched to obtain the structure. This method makes the contact closer between the gold layer and the graphene layer to improve surface plasmon resonance performance. The performance of this type of surface plasmon resonance (SPR) sensor has been previously verified both theoretically and experimentally. With the proposed Au-graphene structure D-type fiber biosensor, the SPR behaviors are obtained and discussed. In the detection of ethanol solution, a red shift of 40 nm is found between the refractive index of 1.3330 and 1.3657. By calculation, the sensitivity of the sensor we designed is 1223 nm\/RIU. Besides, the proposed sensor can detect the nucleotide bonding between the double-stranded DNA helix structures. Thus, our sensors can distinguish between mismatched DNA sequences.<\/jats:p>","DOI":"10.3390\/s20040991","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T03:20:03Z","timestamp":1582168803000},"page":"991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["An Au Nanofilm-Graphene\/D-Type Fiber Surface Plasmon Resonance Sensor for Highly Sensitive Specificity Bioanalysis"],"prefix":"10.3390","volume":"20","author":[{"given":"Xiangtai","family":"Xi","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihua","family":"Xu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuanglu","family":"Li","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Song","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"},{"name":"Shandong Key Laboratory of Medical Physics and Image Processing &amp; Shandong Provincial Engineering and Technical Center of Light Manipulations, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanshun","family":"Han","sequence":"additional","affiliation":[{"name":"Qilu Institute of Technology, Jinan 250200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwei","family":"Fan","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Light Manipulations and Applications in Universities of Shandong School of Physics and Electronics, Shandong Normal University, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28190","DOI":"10.1038\/srep28190","article-title":"Sensitivity enhancement of transition metal dichalcogenides\/silicon nanostructure-based surface plasmon resonance biosensor","volume":"6","author":"Ouyang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.snb.2012.06.013","article-title":"Surface plasmon resonance based fiber optic ammonia gas sensor using ITO and polyaniline","volume":"171","author":"Mishra","year":"2012","journal-title":"Sens. Actuators B Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1002\/adma.201501754","article-title":"Graphene\u2013gold metasurface architectures for ultrasensitive plasmonic biosensing","volume":"27","author":"Zeng","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijleo.2017.01.055","article-title":"SPR based fiber optic sensor with bi layers of indium tin oxide and platinum: A theoretical evaluation","volume":"135","author":"Shah","year":"2017","journal-title":"Optik"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.snb.2017.05.045","article-title":"U-bent fiber optic SPR sensor based on graphene\/AgNPs","volume":"251","author":"Zhang","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1364\/AO.56.003510","article-title":"Numerical simulation on the performance analysis of a graphene-coated optical fiber plasmonic sensor at anti-crossing","volume":"56","author":"Nayak","year":"2017","journal-title":"Appl. Opt."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0925-4005(00)00649-3","article-title":"In-line fiber-optic sensors based on the excitation of surface plasmon modes in metal-coated tapered fibers","volume":"73","author":"Diez","year":"2001","journal-title":"Sens. Actuators B Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.sna.2015.10.030","article-title":"Experimental realization and performance evaluation of refractive index SPR sensor based on unmasked short tapered multimode-fiber operating in aqueous environments","volume":"236","author":"Noor","year":"2015","journal-title":"Sens. Actuators A Phys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.snb.2013.10.067","article-title":"High selectivity and sensitivity sensor based on MIP and SPR in tapered plastic optical fibers for the detection of L-nicotine","volume":"191","author":"Cennamo","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1600185","DOI":"10.1002\/admt.201600185","article-title":"Hybrid Graphene\/Gold Plasmonic Fiber-Optic Biosensor","volume":"2","author":"Zhang","year":"2012","journal-title":"Adv. Mater. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.snb.2017.04.110","article-title":"Sensitivity enhancement by using few-layer black phosphorus-graphene\/TMDCs heterostructure in surface plasmon resonance biochemical sensor","volume":"249","author":"Wu","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1109\/JSEN.2014.2329896","article-title":"A high sensitivity surface plasmon resonance D-shaped fiber sensor based on a waveguide-coupled bimetallic structure: Modeling and optimization","volume":"14","author":"Rezaei","year":"2014","journal-title":"IEEE Sens. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"165105","DOI":"10.1088\/1361-6463\/aa628c","article-title":"A novel U-bent plastic optical fibre local surface plasmon resonance sensor based on a graphene and silver nanoparticle hybrid structure","volume":"50","author":"Jiang","year":"2017","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"305104","DOI":"10.1088\/0022-3727\/49\/30\/305104","article-title":"LSPR enhanced gasoline sensing with a U-bent optical fiber","volume":"49","author":"Paul","year":"2016","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.apsusc.2017.09.113","article-title":"Ultrasensitive label-free detection of DNA hybridization by sapphire-based graphene field-effect transistor biosensor","volume":"427","author":"Xu","year":"2018","journal-title":"Appl. Surf. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.snb.2014.10.124","article-title":"Graphene\u2013MoS2 hybrid nanostructures enhanced surface plasmon resonance biosensors","volume":"207","author":"Zeng","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1021\/nl404795z","article-title":"Graphene\/MoS2 hybrid technology for large scale two-dimensional electronics","volume":"14","author":"Yu","year":"2014","journal-title":"Nano Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.optcom.2017.03.035","article-title":"Design and numerical analysis of highly sensitive Au-MoS2-graphene based hybrid surface plasmon resonance biosensor","volume":"396","author":"Rahman","year":"2017","journal-title":"Opt. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"44559","DOI":"10.1039\/C7RA08246K","article-title":"An electricity-fluorescence double-checking biosensor based on graphene for detection of binding kinetics of DNA hybridization","volume":"7","author":"Yue","year":"2017","journal-title":"RSC Adv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"24811","DOI":"10.1364\/OE.23.024811","article-title":"SERS detection of R6G based on a novel graphene oxide\/silver nanoparticles\/silicon pyramid arrays structure","volume":"23","author":"Zhang","year":"2015","journal-title":"Opt. Express"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"275702","DOI":"10.1088\/0957-4484\/24\/27\/275702","article-title":"Control of density and LSPR of Au nanopar-ticles on graphene","volume":"24","author":"Lee","year":"2013","journal-title":"Nanotechnology."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"315302","DOI":"10.1088\/1361-6463\/aa7b06","article-title":"Evanescent wave absorption sensor with direct-growth MoS2 film based on U-bent tapered multimode fiber","volume":"50","author":"Li","year":"2017","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.optcom.2015.12.071","article-title":"Evanescent wave absorption sensor based on tapered multimode fiber coated with monolayer graphene film","volume":"366","author":"Qiu","year":"2016","journal-title":"Opt. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"053101","DOI":"10.1063\/1.4959982","article-title":"An ultra-high sensitivity surface plasmon resonance sensor based on graphene-aluminum-graphene sandwich-like structure","volume":"120","author":"Xu","year":"2016","journal-title":"J. Appl. Phys."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.snb.2013.01.040","article-title":"Graphene based fiber optic surface plasmon resonance for bio-chemical sensor applications","volume":"187","author":"Kim","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_26","first-page":"1","article-title":"Sensitivity enhancement of D-shape SPR-POF low coast sensor using graphene","volume":"1","author":"Galatus","year":"2013","journal-title":"Int. J. Adv. Res. Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6070742","DOI":"10.1155\/2016\/6070742","article-title":"DNA hybridization detection based on resonance frequency readout in graphene on Au SPR biosensor","volume":"2016","author":"Hossain","year":"2016","journal-title":"J. Sens."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1063\/1.1287631","article-title":"Imaging surface plasmon resonance sensor based on multiple wavelengths: Sensitivity considerations","volume":"71","author":"Johansen","year":"2000","journal-title":"Rev. Sci. Instrum."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1039\/C5NR08866F","article-title":"A graphene-based affinity nanosensor for detection of low-charge and low-molecular-weight molecules","volume":"8","author":"Zhu","year":"2016","journal-title":"Nanoscale"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1166\/jnn.2011.3885","article-title":"Label free DNA detection using large area graphene based field effect transistor biosensors","volume":"11","author":"Guo","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14902","DOI":"10.1038\/ncomms14902","article-title":"Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor","volume":"8","author":"Xu","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bios.2019.04.054","article-title":"Suspended CNT-Based FET sensor for ultrasensitive and label-free detection of DNA hybridization","volume":"137","author":"Sun","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1802440","DOI":"10.1002\/adma.201802440","article-title":"DNA Nanotweezers and Graphene Transistor Enable Label-Free Genotyping","volume":"30","author":"Hwang","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14676","DOI":"10.3390\/s131114676","article-title":"Localized Surface Plasmon Resonance with Five-Branched Gold Nanostars in a Plastic Optical Fiber for Bio-Chemical Sensor Implementation","volume":"13","author":"Cennamo","year":"2013","journal-title":"Sensors"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11744","DOI":"10.1039\/C4NR03275F","article-title":"Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology","volume":"6","author":"Yang","year":"2014","journal-title":"Nanoscale"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.carbon.2017.01.090","article-title":"Tuning the antioxidant activity of graphene quantum dots: Protective nanomaterials against dye decoloration","volume":"116","author":"Ruiz","year":"2017","journal-title":"Carbon"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/4\/991\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:57:15Z","timestamp":1760173035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/4\/991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,12]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["s20040991"],"URL":"https:\/\/doi.org\/10.3390\/s20040991","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,12]]}}}