{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:52:48Z","timestamp":1762005168484,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this study, an efficient and simple designed nanohybrid created for individual and simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). This nanohybrid is a combination of chemical reduced graphene oxide (CRGO) and redox poly(para-phenylene) (Fc-ac-PP) modified in a lateral position with ferrrocenyl group CRGO\/Fc-ac-PPP. The CRGO\/Fc-ac-PPP nanohybrid demonstrated a synergistic effect resulting in a large conductivity, surface area and catalytic properties provided by the redox attached ferrocene. Moreover, this nanocomposite is able to detect individually as well as simultaneously AA, DA and UA in a co-existence system with defined and separated redox peaks oxidation. The linear response ranges for AA, DA and UA, when detected simultaneously, are 0.1\u201310000 \u03bcM, 0.0001\u20131000 \u03bcM and 0.1\u201310000 \u03bcM, respectively, and the detection limits (S\/N = 3) are 0.046 \u03bcM, 0.2 nM and 0.013 \u03bcM, respectively. The proposed sensor shown satisfactory results when applied to real spiked urine samples for measuring the abnormal high or lowconcentration of AA, DA and UA in vivo.<\/jats:p>","DOI":"10.3390\/s20051256","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T04:18:29Z","timestamp":1582690709000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nanocomposite Based on Poly (para-phenylene)\/Chemical Reduced Graphene Oxide as a Platform for Simultaneous Detection of Ascorbic Acid, Dopamine and Uric Acid"],"prefix":"10.3390","volume":"20","author":[{"given":"Zouhour","family":"Hsine","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d\u2019Orsay (ICMMO), Equipe de Chimie Biorganique et Bioinorganique (ECBB), B\u00e2t 420, 2 Rue du Doyen Georges Poitou, 91400 Orsay, France"},{"name":"Laboratory of Interfaces and Advanced Materials, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia"}]},{"given":"Salma","family":"Bizid","sequence":"additional","affiliation":[{"name":"Laboratory of Interfaces and Advanced Materials, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia"}]},{"given":"Rym","family":"Mlika","sequence":"additional","affiliation":[{"name":"Laboratory of Interfaces and Advanced Materials, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia"}]},{"given":"H\u00e9l\u00e8ne","family":"Sauriat-Dorizon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d\u2019Orsay (ICMMO), Equipe de Chimie Biorganique et Bioinorganique (ECBB), B\u00e2t 420, 2 Rue du Doyen Georges Poitou, 91400 Orsay, France"}]},{"given":"Ayoub","family":"Haj Said","sequence":"additional","affiliation":[{"name":"Laboratory of Interfaces and Advanced Materials, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia"}]},{"given":"Hafsa","family":"Korri-Youssoufi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d\u2019Orsay (ICMMO), Equipe de Chimie Biorganique et Bioinorganique (ECBB), B\u00e2t 420, 2 Rue du Doyen Georges Poitou, 91400 Orsay, France"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bioelechem.2008.01.009","article-title":"Simultaneous determination of dopamine, ascorbic acid and uric acid at poly (Evans Blue) modified glassy carbon electrode","volume":"73","author":"Lin","year":"2008","journal-title":"Bioelectrochemistry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bios.2008.06.011","article-title":"Simultaneous electrochemical determination of dopamine, uric acid and ascorbic acid using palladium nanoparticle-loaded carbon nanofibers modified electrode","volume":"24","author":"Huang","year":"2008","journal-title":"Biosens. 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