{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:14:31Z","timestamp":1777180471634,"version":"3.51.4"},"reference-count":103,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005799","name":"National Chiao Tung University","doi-asserted-by":"publisher","award":["108W204, 108W211"],"award-info":[{"award-number":["108W204, 108W211"]}],"id":[{"id":"10.13039\/501100005799","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology Taiwan","award":["MOST 107-2622-E-009-023-CC1, MOST-107-EPA-F-007-002, MOST-108-2636-E-009-007-, MOST-108-2218-E-080-001-"],"award-info":[{"award-number":["MOST 107-2622-E-009-023-CC1, MOST-107-EPA-F-007-002, MOST-108-2636-E-009-007-, MOST-108-2218-E-080-001-"]}]},{"name":"National Health Research Institutes Taiwan","award":["NHRI-EX108-10714EC"],"award-info":[{"award-number":["NHRI-EX108-10714EC"]}]},{"name":"the Higher Education Sprout Project of the National Chiao Tung University and the Ministry of Education, Taiwan","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"the Taiwan Ministry of Science and Technology Academic Excellence Program under Grant Number","award":["MOST 108-2633-B-009-001"],"award-info":[{"award-number":["MOST 108-2633-B-009-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Cancer has been one of the leading causes of death globally, with metastases and recurrences contributing to this result. The detection of circulating tumor cells (CTCs), which have been implicated as a major population of cells that is responsible for seeding and migration of tumor sites, could contribute to early detection of metastasis and recurrences, consequently increasing the chances of cure. This review article focuses on the current progress in microfluidics technology in CTCs diagnostics, extending to the use of nanomaterials and surface modification techniques for diagnostic applications, with an emphasis on the importance of integrating microchannels, nanomaterials, and surface modification techniques in the isolating and detecting of CTCs.<\/jats:p>","DOI":"10.3390\/s20071875","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T03:44:13Z","timestamp":1585712653000},"page":"1875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Microfluidics and Nanomaterial-based Technologies for Circulating Tumor Cell Isolation and Detection"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1473","authenticated-orcid":false,"given":"Sheng-Jen","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3021-7684","authenticated-orcid":false,"given":"Kuan Yu","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"}]},{"given":"Shiue-Luen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-1202","authenticated-orcid":false,"given":"Chong-You","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"}]},{"given":"Chien-Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"}]},{"given":"Hung-I","family":"Tsou","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"}]},{"given":"Priyank V.","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia"}]},{"given":"Jason Chia-Hsun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital (Linkou), Taoyuan 333, Taiwan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-7943","authenticated-orcid":false,"given":"Guan-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan"},{"name":"Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30010, Taiwan"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cell.2016.11.037","article-title":"Emerging biological principles of metastasis","volume":"168","author":"Lambert","year":"2017","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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