{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T21:08:46Z","timestamp":1778360926322,"version":"3.51.4"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"undefined  &lt;span style=&quot;color:gray;font-size:10px;&quot;&gt;undefined&lt;\/span&gt;","award":["PN-III-P1-1.2-PCCDI2017-0221 (INTELMAT)"],"award-info":[{"award-number":["PN-III-P1-1.2-PCCDI2017-0221 (INTELMAT)"]}]},{"name":"Romanian National Authority for Scientific Research and Innovation, CNCS\/CCCDI-UEFISCDI","award":["PN-III-P1-1.2-PCCDI2017-0221 (INTELMAT)"],"award-info":[{"award-number":["PN-III-P1-1.2-PCCDI2017-0221 (INTELMAT)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The detection of folic acid in biological samples or pharmaceutical products is of great importance due to its implications in the biological functions of the human body, along with the development and growth of the fetus. The deficiency of folic acid can be reversed by the intake of different pharmaceutical formulations or alimentary products fortified with this molecule. The elaboration of sensing platforms represents a continuous work in progress, a task in which the use of conductive polymers modified with different functionalities represents one of the outcoming strategies. The possibility of manipulating their morphology with the use of templates or surfactants represents another advantage. A sensing platform based on carboxylic functionalized polypyrrole was synthesized via the electrochemical approach in the presence of a polymeric surfactant on a graphite-based surface. The sensor was able to detect the folic acid from 2.5 \u03bcM to 200 \u03bcM with a calculated limited of detection of 0.8 \u03bcM. It was employed for the detection of the analyte from commercial human serum and pharmaceutical products with excellent recovery rates. The results were double checked using an optimized spectrophotometric procedure that confirmed furthermore the performances of the sensor related to real samples assessment.<\/jats:p>","DOI":"10.3390\/s20082315","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T04:49:38Z","timestamp":1587444578000},"page":"2315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Selective Detection of Folic Acid Using 3D Polymeric Structures of 3-Carboxylic Polypyrrole"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-9738","authenticated-orcid":false,"given":"Gheorghe","family":"Melinte","sequence":"first","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Cernat","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Bianca","family":"Irimes","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs J\u00e1nos","family":"Gy\u00f6rfi","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2572-6724","authenticated-orcid":false,"given":"Mihaela","family":"Terti\u0219","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Suciu","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat St., 400293 Cluj-Napoca, Romania"},{"name":"Biology and Geology Faculty, Babes-Bolyai University, 44 Gheorghe Bila\u015fcu St., 400015 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-2948","authenticated-orcid":false,"given":"Liana","family":"Anic\u0103i","sequence":"additional","affiliation":[{"name":"Center for Surface Science and Nanotechnology, University Polytechnica of Bucharest, 313 Splaiul Independentei St., 060042 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"S\u0103ndulescu","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-3324","authenticated-orcid":false,"given":"Cecilia","family":"Cristea","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 4 Louis Pasteur St., 400349 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285S","DOI":"10.1093\/ajcn\/85.1.285S","article-title":"Folate and neural tube defects","volume":"85","author":"Pitkin","year":"2007","journal-title":"Am. 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