{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:36:30Z","timestamp":1773783390529,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015M3C7A1029034"],"award-info":[{"award-number":["2015M3C7A1029034"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["KHIDI"],"award-info":[{"award-number":["KHIDI"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Computed tomography (CT) is a widely used medical imaging modality for diagnosing various diseases. Among CT techniques, 4-dimensional CT perfusion (4D-CTP) of the brain is established in most centers for diagnosing strokes and is considered the gold standard for hyperacute stroke diagnosis. However, because the detrimental effects of high radiation doses from 4D-CTP may cause serious health risks in stroke survivors, our research team aimed to introduce a novel image-processing technique. Our singular value decomposition (SVD)-based image-processing technique can improve image quality, first, by separating several image components using SVD and, second, by reconstructing signal component images to remove noise, thereby improving image quality. For the demonstration in this study, 20 4D-CTP dynamic images of suspected acute stroke patients were collected. Both the images that were and were not processed via the proposed method were compared. Each acquired image was objectively evaluated using contrast-to-noise and signal-to-noise ratios. The scores of the parameters assessed for the qualitative evaluation of image quality improved to an excellent rating (p &lt; 0.05). Therefore, our SVD-based image-denoising technique improved the diagnostic value of images by improving their quality. The denoising technique and statistical evaluation can be utilized in various clinical applications to provide advanced medical services.<\/jats:p>","DOI":"10.3390\/s20113063","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T12:36:58Z","timestamp":1590669418000},"page":"3063","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Novel Singular Value Decomposition-Based Denoising Method in 4-Dimensional Computed Tomography of the Brain in Stroke Patients with Statistical Evaluation"],"prefix":"10.3390","volume":"20","author":[{"given":"WonSeok","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology, Dong-A University Hospital, Busan 49201, Korea"}]},{"given":"Jun-Yong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Radiological Science, Graduate School, Dongseo University, Busan 47011, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-4065","authenticated-orcid":false,"given":"Jeong-Youn","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinical Emotion and Cognition Research Laboratory, Inje University Ilsan Paik Hospital, Goyang 10380, Korea"}]},{"given":"Seung-ho","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Korea University, Seoul 02841, Korea"},{"name":"KLIEN Inc., Seoul Biohub, 117-3, Hoegi-ro, Dongdaemun-gu, Seoul 02455, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1109-6787","authenticated-orcid":false,"given":"Seung Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Korea University, Seoul 02841, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-4792","authenticated-orcid":false,"given":"Ji-Su","family":"Park","sequence":"additional","affiliation":[{"name":"Advanced Human Resource Development Project Group for Health Care in Aging Friendly Industry, Dongseo University, Busan 47011, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0969-4884","authenticated-orcid":false,"given":"Gihyoun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 02841, Korea"}]},{"given":"Beop Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Korea University, Seoul 02841, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0169-2865","authenticated-orcid":false,"given":"Young-Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Radiological Science, Graduate School, Dongseo University, Busan 47011, Korea"},{"name":"Advanced Human Resource Development Project Group for Health Care in Aging Friendly Industry, Dongseo University, Busan 47011, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1474-4422(03)00266-7","article-title":"Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century","volume":"2","author":"Feigin","year":"2003","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s13311-011-0053-1","article-title":"Stroke epidemiology: advancing our understanding of disease mechanism and therapy","volume":"8","author":"Ovbiagele","year":"2011","journal-title":"Neurotherapeutics"},{"key":"ref_3","first-page":"15","article-title":"Stroke epidemiology and risk factor management","volume":"23","author":"Guzik","year":"2017","journal-title":"Continuum (Minneap. 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