{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:47:08Z","timestamp":1783608428734,"version":"3.55.0"},"reference-count":48,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016M3D1A1027666; 2017R1A2B3009135"],"award-info":[{"award-number":["2016M3D1A1027666; 2017R1A2B3009135"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201808260042"],"award-info":[{"award-number":["201808260042"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The notable toxicological impacts of aflatoxin B1 (AFB1) and its main metabolite, aflatoxin M1 (AFM1), on human being health make the evaluation of food quality highly significant. Due to the toxicity of those metabolites\u2014even very low content in foodstuffs\u2014it is crucial to design a sensitive and reliable procedure for their detection. Electrochemical aptamer-based biosensors are considered the most encouraging option, based on multi-placed analysis, rapid response, high sensitivity and specificity. The present review specifically emphasizes the potential utilization of the electrochemical aptasensors for determining the AFM1 and AFB1 with different electrodes.<\/jats:p>","DOI":"10.3390\/s20113256","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T06:34:16Z","timestamp":1591684456000},"page":"3256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Recent Advances in the Aptamer-Based Electrochemical Biosensors for Detecting Aflatoxin B1 and Its Pertinent Metabolite Aflatoxin M1"],"prefix":"10.3390","volume":"20","author":[{"given":"Hadi","family":"Beitollahi","sequence":"first","affiliation":[{"name":"Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 76315117, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Tajik","sequence":"additional","affiliation":[{"name":"Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 7616913555, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Dourandish","sequence":"additional","affiliation":[{"name":"Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 76315117, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Advanced Organic Materials, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4313-301X","authenticated-orcid":false,"given":"Quyet Van","family":"Le","sequence":"additional","affiliation":[{"name":"Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-7359","authenticated-orcid":false,"given":"Ho Won","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Research Institute of Advanced Materials, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-7991","authenticated-orcid":false,"given":"Soo Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Korea University, 145, Anam-ro Seongbuk-gu, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1416-6805","authenticated-orcid":false,"given":"Mohammadreza","family":"Shokouhimehr","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Research Institute of Advanced Materials, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1002\/elan.201400328","article-title":"Electrochemical aptasensor based on polycarboxylic macrocycle modified with neutral red for aflatoxin B1 detection","volume":"26","author":"Evtugyn","year":"2014","journal-title":"Electroanalysis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.snb.2019.04.092","article-title":"Quartz crystal microbalance sensor based on covalent organic framework composite and molecularly imprinted polymer of poly (o-aminothiophenol) with gold nanoparticles for the determination of aflatoxin B1","volume":"291","author":"Gu","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Evtugyn, G., and Hianik, T. (2019). Electrochemical Immuno-and Aptasensors for Mycotoxin Determination. Chemosensors, 7.","DOI":"10.3390\/chemosensors7010010"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bios.2017.03.028","article-title":"A new amplified \u03c0-shape electrochemical aptasensor for ultrasensitive detection of aflatoxin B1","volume":"94","author":"Abnous","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Espinosa-Calder\u00f3n, A., Contreras-Medina, L.M., Mu\u00f1oz-Huerta, R.F., Mill\u00e1n-Almaraz, J.R., Gonz\u00e1lez, R.G.G., and Torres-Pacheco, I. (2011). Methods for Detection and Quantification of Aflatoxins, Intech Open.","DOI":"10.5772\/28439"},{"key":"ref_6","unstructured":"Dors, G.C., Caldas, S.S., Feddern, V., Bemvenuti, R.H., Hackbart, H.C.S., Souza, M.M., and Furlong, E. (2011). Aflatoxins: Contamination, Analysis and Control, Intech Open."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100290","DOI":"10.1016\/j.sbsr.2019.100290","article-title":"An electrochemical aptasensor based on polythiophene-3-carboxylic acid assisted methylene blue for aflatoxin B1 detection","volume":"25","author":"Zejli","year":"2019","journal-title":"Sens. Biosensing Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.trac.2016.12.003","article-title":"Recent advances in nanomaterial-mediated bio and immune sensors for detection of aflatoxin in food products","volume":"87","author":"Pashazadeh","year":"2017","journal-title":"TrAC Trend. Anal. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/mnfr.200800145","article-title":"Review on sample preparation strategies and methods used for the analysis of aflatoxins in food and feed","volume":"53","author":"Reiter","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0021-9673(00)00930-4","article-title":"Immunoaffinity column clean-up prior to thin-layer chromatography for the determination of aflatoxins in various food matrices","volume":"904","author":"Stroka","year":"2000","journal-title":"J. Chromatogr. A"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1016\/j.chroma.2009.03.035","article-title":"Determination of aflatoxins in food samples by automated on-line in-tube solid-phase microextraction coupled with liquid chromatography\u2013mass spectrometry","volume":"1216","author":"Nonaka","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.chroma.2013.06.049","article-title":"Simultaneous analysis of aflatoxins B1, B2, G1, G2, M1 and ochratoxin A in breast milk by high-performance liquid chromatography\/fluorescence after liquid\u2013liquid extraction with low temperature purification (LLE\u2013LTP)","volume":"1304","author":"Andrade","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1016\/j.bios.2011.02.038","article-title":"Development of an impedimetric aflatoxin M1 biosensor based on a DNA probe and gold nanoparticles","volume":"26","author":"Dinckaya","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bios.2019.01.022","article-title":"Electrochemical aptasensor for aflatoxin B1 based on smart host-guest recognition of \u03b2-cyclodextrin polymer","volume":"129","author":"Wu","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"111777","DOI":"10.1016\/j.bios.2019.111777","article-title":"Recent advances in the development of electrochemical aptasensors for detection of heavy metals in food","volume":"147","author":"Wang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.talanta.2019.04.059","article-title":"Recent progress in the development of recognition bioelements for polychlorinated biphenyls detection: Antibodies and aptamers","volume":"202","author":"Verdian","year":"2019","journal-title":"Talanta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.trac.2015.12.005","article-title":"Antibodies as target for affinity biosensors","volume":"79","author":"Patris","year":"2016","journal-title":"TrAC Trends. Anal. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yadav, G.S., Kumar, V., and Aggarwal, N.K. (2019). Aptamers: Biotechnological Applications of a Next Generation Tool, Springer. [1st ed.].","DOI":"10.1007\/978-981-13-8836-1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bios.2015.04.041","article-title":"Replacing antibodies with aptamers in lateral flow immunoassay","volume":"71","author":"Chen","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bios.2016.01.091","article-title":"Hetero-enzyme-based two-round signal amplification strategy for trace detection of aflatoxin B1 using an electrochemical aptasensor","volume":"80","author":"Zheng","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2018.10.058","article-title":"Electrochemical aptamer-based sensors for food and water analysis: A review","volume":"1051","author":"Li","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.foodchem.2014.12.030","article-title":"Highly sensitive electrochemical impedance spectroscopy immunosensor for the detection of AFB1 in olive oil","volume":"176","author":"Yu","year":"2015","journal-title":"Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bios.2012.11.033","article-title":"A highly selective electrochemical impedance spectroscopy-based aptasensor for sensitive detection of acetamiprid","volume":"43","author":"Fan","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1573411014666180510152154","article-title":"Voltammetric techniques for the analysis of drugs using nanomaterials based chemically modified electrodes","volume":"15","author":"Srivastava","year":"2019","journal-title":"Curr. Anal. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/elan.201900278","article-title":"Voltammetric Label-free Detection of DNA Hypermethylation Using Polypyrrole-modified Microelectrode Array","volume":"31","author":"Meronard","year":"2019","journal-title":"Electroanalysis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ab.2010.09.027","article-title":"Voltammetric techniques for the assay of pharmaceuticals\u2014A review","volume":"408","author":"Gupta","year":"2011","journal-title":"Anal. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.20964\/2019.04.60","article-title":"Voltammetric techniques for pesticides and herbicides detection-an overview","volume":"14","author":"Barbosa","year":"2019","journal-title":"Int. J. Electrochem. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1021\/ac00126a036","article-title":"In situ laser activation of glassy carbon electrodes","volume":"58","author":"Poon","year":"1986","journal-title":"Anal. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1039\/C7AN02050C","article-title":"A novel reduced graphene oxide\/molybdenum disulfide\/polyaniline nanocomposite-based electrochemical aptasensor for detection of aflatoxin B1","volume":"143","author":"Geleta","year":"2018","journal-title":"Analyst"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/elan.201700735","article-title":"Electrochemical aptasensor based on poly (neutral red) and carboxylated pillar [5] arene for sensitive determination of aflatoxin M1","volume":"30","author":"Smolko","year":"2018","journal-title":"Electroanalysis"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Stepanova, V., Smolko, V., Gorbatchuk, V., Stoikov, I., Evtugyn, G., and Hianik, T. (2019). DNA-Polylactide Modified Biosensor for Electrochemical Determination of the DNA-Drugs and Aptamer-Aflatoxin M1 Interactions. Sensors, 19.","DOI":"10.3390\/s19224962"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.electacta.2017.05.089","article-title":"An electrochemical aptasensor based on functionalized graphene oxide assisted electrocatalytic signal amplification of methylene blue for aflatoxin B1 detection","volume":"244","author":"Goud","year":"2017","journal-title":"Electrochim. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.talanta.2015.09.012","article-title":"Development of an impedimetric aptasensor for the determination of aflatoxin M1 in milk","volume":"146","author":"Paniel","year":"2016","journal-title":"Talanta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.snb.2016.05.112","article-title":"Disposable and portable electrochemical aptasensor for label free detection of aflatoxin B1 in alcoholic beverages","volume":"235","author":"Goud","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s13204-017-0629-0","article-title":"Immobilized aptamer on gold electrode senses trace amount of aflatoxin M1","volume":"7","author":"Pandey","year":"2017","journal-title":"Appl. Nanosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.bios.2018.06.055","article-title":"A novel electrochemical aptasensor for detection of aflatoxin M1 based on target-induced immobilization of gold nanoparticles on the surface of electrode","volume":"117","author":"Jalalian","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bios.2018.02.043","article-title":"Fabrication of magnetically assembled aptasensing device for label-free determination of aflatoxin B1 based on EIS","volume":"108","author":"Wang","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.talanta.2018.11.026","article-title":"Design of a redox-active surface for ultrasensitive redox capacitive aptasensing of aflatoxin M1 in milk","volume":"195","author":"Aissa","year":"2019","journal-title":"Talanta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.talanta.2019.05.044","article-title":"Electrochemical enzyme-linked oligonucleotide array for aflatoxin B1 detection","volume":"203","author":"Selvolini","year":"2019","journal-title":"Talanta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodcont.2014.12.008","article-title":"Detection of aflatoxin B1 by aptamer-based biosensor using PAMAM dendrimers as immobilization platform","volume":"52","author":"Castillo","year":"2015","journal-title":"Food Control"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Karapetis, S., Nikolelis, D., and Hianik, T. (2018). Label-free and redox markers-based electrochemical aptasensors for aflatoxin M1 detection. Sensors, 18.","DOI":"10.3390\/s18124218"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17551","DOI":"10.1021\/acsami.8b01693","article-title":"Aflatoxin B1 electrochemical aptasensor based on tetrahedral DNA nanostructures functionalized three dimensionally ordered macroporous MoS2\u2013AuNPs film","volume":"10","author":"Peng","year":"2018","journal-title":"ACS Appl. Mater. Inter."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00604-014-1181-1","article-title":"Screen-printed electrodes for biosensing: A review (2008\u20132013)","volume":"181","author":"Taleat","year":"2014","journal-title":"Microchim. Acta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"108256","DOI":"10.1016\/j.matdes.2019.108256","article-title":"Ordered micropillar array gold electrode increases electrochemical signature of early biofilm attachment","volume":"185","author":"Astorga","year":"2020","journal-title":"Mater. Des."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s11164-018-3621-8","article-title":"Facile synthesis of monodispersed Pd nanocatalysts decorated on graphene oxide for reduction of nitroaromatics in aqueous solution","volume":"45","author":"Zhang","year":"2019","journal-title":"Res. Chem. Intermediat."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40580-019-0176-3","article-title":"Copper oxide\u2013graphene oxide nanocomposite: Efficient catalyst for hydrogenation of nitroaromatics in water","volume":"6","author":"Zhang","year":"2019","journal-title":"Nano Converg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1166\/nnl.2013.1616","article-title":"Metal hexacyanoferrate nanoparticles as electrode materials for lithium ion batteries","volume":"5","author":"Shokouhimehr","year":"2013","journal-title":"Nanosci. Nanotech. Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15171","DOI":"10.1039\/D0RA02380A","article-title":"Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe3O4\/CuO): Modified screen-printed electrode for electrochemical studies and detection of desipramine","volume":"10","author":"Tajik","year":"2020","journal-title":"RSC Adv."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/11\/3256\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:36:37Z","timestamp":1760175397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/11\/3256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["s20113256"],"URL":"https:\/\/doi.org\/10.3390\/s20113256","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]}}}