{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:34:08Z","timestamp":1782912848016,"version":"3.54.5"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11621101"],"award-info":[{"award-number":["11621101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["No. 2018YFC1407500"],"award-info":[{"award-number":["No. 2018YFC1407500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>It is generally difficult to characterize inert gases through chemical reactions due to their inert chemical properties. The phase interference-sensing system based on high-resolution surface plasmon resonance (SPR) has an excellent refractive index detection limit. Based on this, this paper presents a simple and workable method for the characterization and detection of inert gases. The phase of light for the present SPR sensor is more sensitive to the change in the external dielectric environment than an amplitude SPR sensor. The limit of detection (LOD) is usually in the order of 10\u22126 to 10\u22127 RIU, which is superior to LSPR (Localized Surface Plasmon Resonance) sensors and traditional SPR sensors. The sensor parameters are simulated and optimized. Our simulation shows that a 36 nm-thick gold film is more suitable for the SPR sensing of inert gases. By periodically switching between the two inert gases, helium and argon, the resolution of the system is tested. The SPR sensing system can achieve distinguishable difference signals, enabling a clear distinction and characterization of helium and argon. The doping of argon in helium has a detection limit of 1098 ppm.<\/jats:p>","DOI":"10.3390\/s20113295","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T05:11:46Z","timestamp":1591765906000},"page":"3295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Characterization and Sensing of Inert Gases with a High-Resolution SPR Sensor"],"prefix":"10.3390","volume":"20","author":[{"given":"Zhenchao","family":"Liu","sequence":"first","affiliation":[{"name":"Centre for Optical and Electromagnetic Research, National Engineering Research Center for Optical Instruments, Zhejiang University, Hangzhou 310058, China"},{"name":"Ningbo Research Institute, Zhejiang University, Ningbo 315100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"He","sequence":"additional","affiliation":[{"name":"College of Modern Science and Technology, China Jiliang University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailing","family":"He","sequence":"additional","affiliation":[{"name":"Centre for Optical and Electromagnetic Research, National Engineering Research Center for Optical Instruments, Zhejiang University, Hangzhou 310058, China"},{"name":"Ningbo Research Institute, Zhejiang University, Ningbo 315100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0301-0104(75)80146-7","article-title":"Excimer emission spectrum in noble gas systems","volume":"8","author":"Yakhot","year":"1975","journal-title":"Chem. Phys."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijms.2010.07.014","article-title":"Improvement of the resonance ionization mass spectrometer performance for precise isotope analysis of krypton and xenon at the ppt level in argon","volume":"296","author":"Iwata","year":"2010","journal-title":"Int. J. Mass Spectrom."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00584239","article-title":"Technique for measurement of inert gases in liquids by gas chromatography","volume":"375","author":"Meyer","year":"1978","journal-title":"Pfl\u00fcgers Archiv"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chroma.2008.05.066","article-title":"Determination of anethole in serum samples by headspace solid-phase microextraction-gas chromatography-mass spectrometry for congener analysis","volume":"1200","author":"Schulz","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.snb.2007.08.012","article-title":"Surface plasmon resonance sensor based on an array of diffraction gratings for highly parallelized observation of biomolecular interactions","volume":"129","author":"Dostalek","year":"2008","journal-title":"Sens. Actuators B Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ymeth.2005.05.003","article-title":"Multi-analyte surface plasmon resonance biosensing","volume":"37","author":"Homola","year":"2005","journal-title":"Methods"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0925-4005(98)00321-9","article-title":"Surface plasmon resonance sensors: Review","volume":"54","author":"Homola","year":"1999","journal-title":"Sens. Actuators B Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.saa.2017.10.039","article-title":"A novel surface plasmon resonance biosensor based on the PDA-AgNPs-PDA-Au film sensing platform for horse IgG detection","volume":"191","author":"Wang","year":"2018","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/andp.201200203","article-title":"Phase-sensitive surface plasmon resonance biosensors: Methodology, instrumentation and applications","volume":"524","author":"Huang","year":"2012","journal-title":"Ann. Phys."},{"key":"ref_10","first-page":"7","article-title":"The effects of magnetic fields exposure on relative permittivity of saline solutions measured by a high resolution SPR system","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"21191","DOI":"10.1364\/OE.17.021191","article-title":"Phase and amplitude sensitivities in surface plasmon resonance bio and chemical sensing","volume":"17","author":"Kabashin","year":"2009","journal-title":"Opt. Express"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bios.2018.03.051","article-title":"Nanomaterials and phase sensitive based signal enhancment in surface plasmon resonance","volume":"110","author":"Keshtkar","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bios.2008.06.013","article-title":"Real-time protein biosensor arrays based on surface plasmon resonance differential phase imaging","volume":"24","author":"Wong","year":"2008","journal-title":"Biosens. Bioelectron."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/14786440209462857","article-title":"On a remarkable case of uneven distribution of light in a diffraction grating spectrum","volume":"4","author":"Wood","year":"1902","journal-title":"Philos. Mag."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1364\/JOSA.31.000213","article-title":"The Theory of Anomalous Diffraction Gratings and of Quasi-Stationary Waves on Metallic Surfaces (Sommerfeld\u2019s Waves)","volume":"31","author":"Fano","year":"1941","journal-title":"J. Opt. Soc. Am."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1515\/zna-1968-1247","article-title":"Notizen: Radiative Decay of Non Radiative Surface Plasmons Excited by Light","volume":"23","author":"Kretschmann","year":"1968","journal-title":"Zeitschrift f\u00fcr Naturforschung A"},{"key":"ref_17","first-page":"398","article-title":"Excitation of Nonradiative Surface Plasma Waves in Silver by Method of Frustrated Total Reflection","volume":"216","author":"Otto","year":"1968","journal-title":"Eur. Phys. J. A"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0250-6874(83)85036-7","article-title":"Surface-Plasmon resonance for gas-detection and biosensing","volume":"4","author":"Liedberg","year":"1983","journal-title":"Sens. Actuators"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.snb.2011.07.030","article-title":"Enhancing the gas sensitivity of surface plasmon resonance with a nanoporous silica matrix","volume":"160","author":"Berrier","year":"2011","journal-title":"Sens. Actuators B Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jhazmat.2019.120919","article-title":"Room-temperature gas sensors based on ZnO nanorod\/Au hybrids: Visible-light-modulated dual selectivity to NO2 and NH3","volume":"381","author":"Wang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1140\/epjp\/i2019-12646-6","article-title":"Optical detection of CO gas by the surface-plasmon resonance of Ag nanoparticles and nanoclusters synthesized on a hydrogenated amorphous carbon (a-C:H) film","volume":"134","author":"Ahmadirad","year":"2019","journal-title":"Eur. Phys. J. Plus"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lo, T.-H., Shih, P.-Y., and Wu, C.-H. (2019). The Response of UV\/Blue Light and Ozone Sensing Using Ag-TiO2 Planar Nanocomposite Thin Film. Sensors, 19.","DOI":"10.3390\/s19235061"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41467-019-09008-0","article-title":"Gas identification with graphene plasmons","volume":"10","author":"Hu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wei, W., Nong, J., Zhang, G., Tang, L., Jiang, X., Chen, N., Luo, S., Lan, G., and Zhu, Y. (2017). Graphene-Based Long-Period Fiber Grating Surface Plasmon Resonance Sensor for High-Sensitivity Gas Sensing. Sensors, 17.","DOI":"10.3390\/s17010002"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17358","DOI":"10.1021\/ja1074272","article-title":"Gas Sensing with High-Resolution Localized Surface Plasmon Resonance Spectroscopy","volume":"132","author":"Bingham","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.aca.2013.10.048","article-title":"Trends and challenges of refractometric nanoplasmonic biosensors: A review","volume":"806","author":"Estevez","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1039\/C9AN00701F","article-title":"Advances in nanoplasmonic biosensors for clinical applications","volume":"144","author":"Mauriz","year":"2019","journal-title":"Analyst"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/11\/3295\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:37:17Z","timestamp":1760175437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/11\/3295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["s20113295"],"URL":"https:\/\/doi.org\/10.3390\/s20113295","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]}}}