{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:22:23Z","timestamp":1784920943933,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The emergence of biomedical sensor devices, wireless communication, and innovation in other technologies for healthcare applications result in the evolution of a new area of research that is termed as Wireless Body Area Networks (WBANs). WBAN originates from Wireless Sensor Networks (WSNs), which are used for implementing many healthcare systems integrated with networks and wireless devices to ensure remote healthcare monitoring. WBAN is a network of wearable devices implanted in or on the human body. The main aim of WBAN is to collect the human vital signs\/physiological data (like ECG, body temperature, EMG, glucose level, etc.) round-the-clock from patients that demand secure, optimal and efficient routing techniques. The efficient, secure, and reliable designing of routing protocol is a difficult task in WBAN due to its diverse characteristic and restraints, such as energy consumption and temperature-rise of implanted sensors. The two significant constraints, overheating of nodes and energy efficiency must be taken into account while designing a reliable blockchain-enabled WBAN routing protocol. The purpose of this study is to achieve stability and efficiency in the routing of WBAN through managing temperature and energy limitations. Moreover, the blockchain provides security, transparency, and lightweight solution for the interoperability of physiological data with other medical personnel in the healthcare ecosystem. In this research work, the blockchain-based Adaptive Thermal-\/Energy-Aware Routing (ATEAR) protocol for WBAN is proposed. Temperature rise, energy consumption, and throughput are the evaluation metrics considered to analyze the performance of ATEAR for data transmission. In contrast, transaction throughput, latency, and resource utilization are used to investigate the outcome of the blockchain system. Hyperledger Caliper, a benchmarking tool, is used to evaluate the performance of the blockchain system in terms of CPU utilization, memory, and memory utilization. The results show that by preserving residual energy and avoiding overheated nodes as forwarders, high throughput is achieved with the ultimate increase of the network lifetime. Castalia, a simulation tool, is used to evaluate the performance of the proposed protocol, and its comparison is made with Multipath Ring Routing Protocol (MRRP), thermal-aware routing algorithm (TARA), and Shortest-Hop (SHR). Evaluation results illustrate that the proposed protocol performs significantly better in balancing of temperature (to avoid damaging heat effect on the body tissues) and energy consumption (to prevent the replacement of battery and to increase the embedded sensor node life) with efficient data transmission achieving a high throughput value.<\/jats:p>","DOI":"10.3390\/s20123604","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T11:17:17Z","timestamp":1593429437000},"page":"3604","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Towards a Secure Thermal-Energy Aware Routing Protocol in Wireless Body Area Network Based on Blockchain Technology"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-1799","authenticated-orcid":false,"given":"Zeinab","family":"Shahbazi","sequence":"first","affiliation":[{"name":"Department of Computer Engineering, Jeju National University, Jejusi 63243, Jeju Special Self-Governing, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Cheol","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Jeju National University, Jejusi 63243, Jeju Special Self-Governing, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jamil, F., Hang, L., Kim, K., and Kim, D. (2019). A Novel Medical Blockchain Model for Drug Supply Chain Integrity Management in a Smart Hospital. Electronics, 8.","DOI":"10.3390\/electronics8050505"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Qadri, R., and Faiq, M.A. (2020). Freshwater Pollution: Effects on Aquatic Life and Human Health. Fresh Water Pollution Dynamics and Remediation, Springer.","DOI":"10.1007\/978-981-13-8277-2_2"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jamil, F., Ahmad, S., Iqbal, N., and Kim, D.H. (2020). Towards a Remote Monitoring of Patient Vital Signs Based on IoT-Based Blockchain Integrity Management Platforms in Smart Hospitals. Sensors, 20.","DOI":"10.3390\/s20082195"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jnca.2019.06.016","article-title":"A comprehensive review of wireless body area network","volume":"143","author":"Hasan","year":"2019","journal-title":"J. Netw. Comput. Appl."},{"key":"ref_5","unstructured":"Baig, M.M. (2014). Smart Vital Signs Monitoring and Novel Falls Prediction System for Older Adults. [Ph.D. Thesis, Auckland University of Technology]."},{"key":"ref_6","unstructured":"World Health Organization (2010). Telemedicine: Opportunities and Developments in Member States. Report on the Second Global Survey on eHealth, World Health Organization."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10916-010-9496-x","article-title":"Mobile telemedicine: A survey study","volume":"36","author":"Lin","year":"2012","journal-title":"J. Med. Syst."},{"key":"ref_8","unstructured":"Mihai, D.M. (2019). Distributed Telemedicine System and Method. (10,430,552), U.S. Patent."},{"key":"ref_9","unstructured":"Desgranges, P.Z., and Yaghmai, E. (2019). Smartphone Based Telemedicine System. (10,216,906), U.S. Patent."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hang, L., and Kim, D.H. (2019). Design and implementation of an integrated IoT blockchain platform for sensing data integrity. Sensors, 19.","DOI":"10.3390\/s19102228"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hang, L., Choi, E., and Kim, D.H. (2019). A novel EMR integrity management based on a medical blockchain platform in hospital. Electronics, 8.","DOI":"10.3390\/electronics8040467"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pramanik, P.K.D., Nayyar, A., and Pareek, G. (2019). WBAN: Driving e-healthcare Beyond Telemedicine to Remote Health Monitoring: Architecture and Protocols. Telemedicine Technologies, Elsevier.","DOI":"10.1016\/B978-0-12-816948-3.00007-6"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Patel, W.D., Pandya, S., Koyuncu, B., Ramani, B., Bhaskar, S., and Ghayvat, H. (December, January 30). NXTGeUH: LoRaWAN based NEXT Generation Ubiquitous Healthcare System for Vital Signs Monitoring & Falls Detection. Proceedings of the 2018 IEEE Punecon, Pune, India.","DOI":"10.1109\/PUNECON.2018.8745431"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chiuchisan, I., Geman, O., and Hagan, M. (2019, January 29\u201330). Wearable Sensors in Intelligent Clothing for Human Activity Monitoring. Proceedings of the 2019 International Conference on Sensing and Instrumentation in IoT Era (ISSI), Lisbon, Portugal.","DOI":"10.1109\/ISSI47111.2019.9043649"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Qu, Y., Zheng, G., Ma, H., Wang, X., Ji, B., and Wu, H. (2019). A survey of routing protocols in WBAN for healthcare applications. Sensors, 19.","DOI":"10.3390\/s19071638"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pediaditakis, D., Tselishchev, Y., and Boulis, A. (2010, January 16\u201318). Performance and scalability evaluation of the Castalia wireless sensor network simulator. Proceedings of the 3rd International ICST Conference on Simulation Tools and Techniques, Malaga, Spain.","DOI":"10.4108\/ICST.SIMUTOOLS2010.8727"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sukhwani, H., Wang, N., Trivedi, K.S., and Rindos, A. (2018, January 1\u20133). Performance modeling of hyperledger fabric (permissioned blockchain network). Proceedings of the 2018 IEEE 17th International Symposium on Network Computing and Applications (NCA), Cambridge, MA, USA.","DOI":"10.1109\/NCA.2018.8548070"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Quwaider, M., and Biswas, S. (2009, January 26). Probabilistic routing in on-body sensor networks with postural disconnections. Proceedings of the 7th ACM International Symposium on Mobility Management and Wireless Access, Tenerife, Spain.","DOI":"10.1145\/1641776.1641803"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.12928\/telkomnika.v13i1.365","article-title":"Critical data routing (cdr) for intra wireless body sensor networks","volume":"13","author":"Bangash","year":"2015","journal-title":"Telkomnika"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yousaf, S., Ahmed, S., Akbar, M., Javaid, N., Khan, Z.A., and Qasim, U. (2014, January 8\u201310). Co-CEStat: Cooperative critical data transmission in emergency in static wireless body area network. Proceedings of the 2014 Ninth International Conference on Broadband and Wireless Computing, Communication and Applications, Guangdong, China.","DOI":"10.1109\/BWCCA.2014.54"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Guo, C., Prasad, R.V., and Jacobsson, M. (2010, January 9\u201312). Packet forwarding with minimum energy consumption in body area sensor networks. Proceedings of the 2010 7th IEEE Consumer Communications and Networking Conference, Las Vegas, NV, USA.","DOI":"10.1109\/CCNC.2010.5421768"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"437926","DOI":"10.1155\/2013\/437926","article-title":"QoS and energy aware cooperative routing protocol for wildfire monitoring wireless sensor networks","volume":"2013","author":"Maalej","year":"2013","journal-title":"Sci. World J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.procs.2013.06.027","article-title":"A QoS-aware routing protocol for reliability sensitive data in hospital body area networks","volume":"19","author":"Khan","year":"2013","journal-title":"Procedia Comput. Sci."},{"key":"ref_24","unstructured":"Liang, X., Balasingham, I., and Byun, S.S. (2008, January 25\u201328). A reinforcement learning based routing protocol with QoS support for biomedical sensor networks. Proceedings of the 2008 First International Symposium on Applied Sciences on Biomedical and Communication Technologies, Aalborg, Denmark."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ayatollahitafti, V., Ngadi, M.A., bin Mohamad Sharif, J., and Abdullahi, M. (2016). An efficient next hop selection algorithm for multi-hop body area networks. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146464"},{"key":"ref_26","first-page":"295","article-title":"Cost based efficient routing for wireless body area networks","volume":"4","author":"Kaur","year":"2015","journal-title":"Int. J. Comput. Sci. Mob. Comput."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11235-014-9901-8","article-title":"A cross-layer QoS-aware optimization protocol for guaranteed data streaming over wireless body area networks","volume":"58","author":"Ababneh","year":"2015","journal-title":"Telecommun. Syst."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Khan, Z., Sivakumar, S., Phillips, W., and Robertson, B. (2012, January 12\u201314). QPRD: QoS-aware peering routing protocol for delay sensitive data in hospital body area network communication. Proceedings of the 2012 Seventh International Conference on Broadband, Wireless Computing, Communication and Applications, Victoria, BC, Canada.","DOI":"10.1109\/BWCCA.2012.37"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Movassaghi, S., Abolhasan, M., and Lipman, J. (2012, January 9\u201312). Energy efficient thermal and power aware (ETPA) routing in body area networks. Proceedings of the 2012 IEEE 23rd International Symposium on Personal, Indoor and Mobile Radio Communications-(PIMRC), Sydney, NSW, Australia.","DOI":"10.1109\/PIMRC.2012.6362511"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Liang, X., Li, X., Shen, Q., Lu, R., Lin, X., Shen, X., and Zhuang, W. (2012, January 25\u201330). Exploiting prediction to enable secure and reliable routing in wireless body area networks. Proceedings of the 2012 Proceedings IEEE INFOCOM, Orlando, FL, USA.","DOI":"10.1109\/INFCOM.2012.6195777"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.adhoc.2010.03.002","article-title":"DTN routing in body sensor networks with dynamic postural partitioning","volume":"8","author":"Quwaider","year":"2010","journal-title":"Ad Hoc Netw."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Tauqir, A., Javaid, N., Akram, S., Rao, A., and Mohammad, S.N. (2013, January 28\u201330). Distance aware relaying energy-efficient: Dare to monitor patients in multi-hop body area sensor networks. Proceedings of the 2013 Eighth International Conference on Broadband and Wireless Computing, Communication and Applications, Compiegne, France.","DOI":"10.1109\/BWCCA.2013.40"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12652-013-0195-6","article-title":"A new patient monitoring framework and Energy-aware Peering Routing Protocol (EPR) for Body Area Network communication","volume":"5","author":"Khan","year":"2014","journal-title":"J. Ambient. Intell. Humaniz. Comput."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Nadeem, Q., Javaid, N., Mohammad, S.N., Khan, M., Sarfraz, S., and Gull, M. (2013, January 28\u201330). Simple: Stable increased-throughput multi-hop protocol for link efficiency in wireless body area networks. Proceedings of the 2013 Eighth International Conference on Broadband and Wireless Computing, Communication and Applications, Compiegne, France.","DOI":"10.1109\/BWCCA.2013.42"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Jamil, F., Iqbal, M.A., Amin, R., and Kim, D. (2019). Adaptive thermal-aware routing protocol for wireless body area network. Electronics, 8.","DOI":"10.3390\/electronics8010047"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ren, H., and Meng, M.Q.H. (2006, January 17\u201321). Rate control to reduce bioeffects in wireless biomedical sensor networks. Proceedings of the 2006 Third Annual International Conference on Mobile and Ubiquitous Systems: Networking & Services, San Jose, CA, USA.","DOI":"10.1109\/MOBIQ.2006.340442"},{"key":"ref_37","first-page":"260","article-title":"M2E2: A novel multi-hop routing protocol for wireless body sensor networks","volume":"2","author":"Rafatkhah","year":"2014","journal-title":"Int. J. Comput. Netw. Commun. Secur."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"464010","DOI":"10.1155\/2014\/464010","article-title":"RE-ATTEMPT: A new energy-efficient routing protocol for wireless body area sensor networks","volume":"10","author":"Ahmad","year":"2014","journal-title":"Int. J. Distrib. Sens. Netw."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"676312","DOI":"10.1155\/2014\/676312","article-title":"Thermal-aware multiconstrained intrabody QoS routing for wireless body area networks","volume":"10","author":"Monowar","year":"2014","journal-title":"Int. J. Distrib. Sens. Netw."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.inffus.2007.02.001","article-title":"Hotspot preventing routing algorithm for delay-sensitive applications of in vivo biomedical sensor networks","volume":"9","author":"Bag","year":"2008","journal-title":"Inf. Fusion"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ahourai, F., Tabandeh, M., Jahed, M., and Moradi, S. (2009, January 27\u201329). A thermal-aware shortest hop routing algorithm for in vivo biomedical sensor networks. Proceedings of the 2009 Sixth International Conference on Information Technology: New Generations, Las Vegas, NV, USA.","DOI":"10.1109\/ITNG.2009.274"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bag, A., and Bassiouni, M.A. (2008, January 12\u201314). Routing algorithm for network of homogeneous and id-less biomedical sensor nodes (RAIN). Proceedings of the 2008 IEEE Sensors Applications Symposium, Atlanta, GA, USA.","DOI":"10.1109\/SAS13374.2008.4472946"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Takahashi, D., Xiao, Y., and Hu, F. (2007, January 26\u201330). LTRT: Least total-route temperature routing for embedded biomedical sensor networks. Proceedings of the IEEE GLOBECOM 2007-IEEE Global Telecommunications Conference, Washington, DC, USA.","DOI":"10.1109\/GLOCOM.2007.125"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Bag, A., and Bassiouni, M.A. (2006, January 9\u201312). Energy efficient thermal aware routing algorithms for embedded biomedical sensor networks. Proceedings of the 2006 IEEE International Conference on Mobile Ad Hoc and Sensor Systems, Vancouver, BC, Canada.","DOI":"10.1109\/MOBHOC.2006.278619"},{"key":"ref_45","unstructured":"Tang, Q., Tummala, N., Gupta, S.K., and Schwiebert, L. (July, January 30). TARA: Thermal-aware routing algorithm for implanted sensor networks. Proceedings of the International Conference on Distributed Computing in Sensor Systems, Marina del Rey, CA, USA."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1145\/980159.980169","article-title":"Design and analysis of hybrid indirect transmissions (HIT) for data gathering in wireless micro sensor networks","volume":"8","author":"Culpepper","year":"2004","journal-title":"ACM SIGMOBILE Mobile Comput. Commun. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Watteyne, T., Aug\u00e9-Blum, I., Dohler, M., and Barthel, D. (2007, January 11\u201313). Anybody: A self-organization protocol for body area networks. Proceedings of the ICST 2nd International Conference on Body Area Networks, Florence, Italy.","DOI":"10.4108\/bodynets.2007.186"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3923\/tasr.2016.12.18","article-title":"Cluster Based Energy Efficient Routing Protocol for Wireless Body Area Networks","volume":"11","author":"Alghamdi","year":"2016","journal-title":"Trends Appl. Sci. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/17445760802335345","article-title":"Biocomm\u2014A cross-layer medium access control (MAC) and routing protocol co-design for biomedical sensor networks","volume":"24","author":"Bag","year":"2009","journal-title":"Int. J. Parallel Emergent Distrib. Syst."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ruzzelli, A.G., Jurdak, R., O\u2019Hare, G.M., and Van Der Stok, P. (2007, January 11). Energy-efficient multi-hop medical sensor networking. Proceedings of the 1st ACM SIGMOBILE International Workshop on Systems and Networking Support for Healthcare and Assisted Living Environments, San Juan, Puerto Rico.","DOI":"10.1145\/1248054.1248064"},{"key":"ref_51","unstructured":"Demeester, P., Blondia, C., Braem, B., Latre, B., Joseph, W., Reusens, E., and Moerman, I. (2007, January 6\u201310). A low-delay protocol for multihop wireless body area networks. Proceedings of the 2007 Fourth Annual International Conference on Mobile and Ubiquitous Systems: Networking and Services (MobiQuitous), Philadelphia, PA, USA."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Braem, B., Latre, B., Moerman, I., Blondia, C., and Demeester, P. (2006, January 17\u201321). The wireless autonomous spanning tree protocol for multihop wireless body area networks. Proceedings of the 2006 Third Annual International Conference on Mobile and Ubiquitous Systems: Networking & Services, San Jose, CA, USA.","DOI":"10.1109\/MOBIQ.2006.340421"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s10916-018-0982-x","article-title":"Healthcare blockchain system using smart contracts for secure automated remote patient monitoring","volume":"42","author":"Griggs","year":"2018","journal-title":"J. Med. Syst."},{"key":"ref_54","unstructured":"Hasan, K., Biswas, K., Ahmed, K., and Islam, M.S. (2018, January 16). Challenges of Integrating Blockchain in Wireless Body Area Network. Proceedings of the 3rd Symposium on Distributed Ledger Technology, Mount Gravatt, Australia."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kumari, R., Nand, P., and Astya, R. (2019, January 18\u201319). Integration of Blockchain in WBAN. Proceedings of the 2019 International Conference on Computing Communication and Intelligent Systems (ICCCIS), Greater Noida, India.","DOI":"10.1109\/ICCCIS48478.2019.8974478"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11235-020-00662-0","article-title":"Authenticated key agreement for blockchain-based WBAN","volume":"74","author":"Mwitende","year":"2020","journal-title":"Telecommun. Syst."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.future.2019.09.049","article-title":"A blockchain-based eHealthcare system interoperating with WBANs","volume":"110","author":"Wang","year":"2019","journal-title":"Future Gener. Comput. Syst."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Varga, A. (2010). OMNeT++. Modeling and Tools for Network Simulation, Springer.","DOI":"10.1007\/978-3-642-12331-3_3"},{"key":"ref_59","unstructured":"Caliper, H. (2019, October 03). Hyperledger Caliper Architecture. Electronic Article. Available online: https:\/\/hyperledger.github.io\/caliper\/docs\/2_Architecture.html."},{"key":"ref_60","unstructured":"Eyal, I., Gencer, A.E., Sirer, E.G., and Van Renesse, R. (2016, January 2). Bitcoin-ng: A scalable blockchain protocol. Proceedings of the 13th {USENIX} sYmposium on Networked Systems Design and Implementation ({NSDI} 16), Santa Clara, CA, USA."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/12\/3604\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:43:18Z","timestamp":1760175798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/12\/3604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":60,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["s20123604"],"URL":"https:\/\/doi.org\/10.3390\/s20123604","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]}}}