{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:01:22Z","timestamp":1760238082233,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["PDO Renard M","SCI De Backer J"],"award-info":[{"award-number":["PDO Renard M","SCI De Backer J"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["794365"],"award-info":[{"award-number":["794365"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","award":["01M01108"],"award-info":[{"award-number":["01M01108"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Ambulatory electrocardiography (AECG) is a primary diagnostic tool in patients with potential arrhythmic disorders. To study the pathophysiological mechanisms of arrhythmic disorders, mouse models are widely implemented. The use of a technique similar to AECG for mice is thus of great relevance. We have optimized a protocol which allows qualitative, long-term ECG data recording in conscious, freely moving mice. Automated algorithms were developed to efficiently process the large amount of data and calculate the average heart rate (HR), the mean peak-to-peak interval and heart rate variability (HRV) based on peak detection. Ectopic beats are automatically detected based on aberrant peak intervals. As we have incorporated a multiple lead configuration in our ECG set-up, the nature and origin of the suggested ectopic beats can be analyzed in detail. The protocol and analysis tools presented here are promising tools for studies which require detailed, long-term ECG characterization in mouse models with potential arrhythmic disorders.<\/jats:p>","DOI":"10.3390\/s20143867","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T09:30:49Z","timestamp":1594719049000},"page":"3867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice"],"prefix":"10.3390","volume":"20","author":[{"given":"Felke","family":"Steijns","sequence":"first","affiliation":[{"name":"Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1t\u00e9 I.","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Institute Biomedical Technology, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-6396","authenticated-orcid":false,"given":"Anthony","family":"Demolder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars E.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Institute Biomedical Technology, Ghent University, 9000 Ghent, Belgium"},{"name":"4BRAIN, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-3983","authenticated-orcid":false,"given":"Jana","family":"Desloovere","sequence":"additional","affiliation":[{"name":"4BRAIN, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolijn","family":"Renard","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robrecht","family":"Raedt","sequence":"additional","affiliation":[{"name":"4BRAIN, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3870-3409","authenticated-orcid":false,"given":"Patrick","family":"Segers","sequence":"additional","affiliation":[{"name":"Institute Biomedical Technology, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-1507","authenticated-orcid":false,"given":"Julie","family":"De Backer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-5980","authenticated-orcid":false,"given":"Patrick","family":"Sips","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"ref_1","first-page":"189","article-title":"Cardiovascular disease in Europe: Epidemiological update 2016 (vol 37, pg 3232, 2017)","volume":"40","author":"Townsend","year":"2019","journal-title":"Eur. 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