{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:05:50Z","timestamp":1773479150485,"version":"3.50.1"},"reference-count":212,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013349","name":"LABoratoires d\u2019EXcellence ARCANE","doi-asserted-by":"publisher","award":["CBH-EUR-GS (ANR-17-EURE-0003)"],"award-info":[{"award-number":["CBH-EUR-GS (ANR-17-EURE-0003)"]}],"id":[{"id":"10.13039\/100013349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LANEF","award":["ANR-10-LABX-51-01"],"award-info":[{"award-number":["ANR-10-LABX-51-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In the 90s, the development of a novel single molecule technique based on nanopore sensing emerged. Preliminary improvements were based on the molecular or biological engineering of protein nanopores along with the use of nanotechnologies developed in the context of microelectronics. Since the last decade, the convergence between those two worlds has allowed for biomimetic approaches. In this respect, the combination of nanopores with aptamers, single-stranded oligonucleotides specifically selected towards molecular or cellular targets from an in vitro method, gained a lot of interest with potential applications for the single molecule detection and recognition in various domains like health, environment or security. The recent developments performed by combining nanopores and aptamers are highlighted in this review and some perspectives are drawn.<\/jats:p>","DOI":"10.3390\/s20164495","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T10:56:12Z","timestamp":1597143372000},"page":"4495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sensing with Nanopores and Aptamers: A Way Forward"],"prefix":"10.3390","volume":"20","author":[{"given":"Lucile","family":"Reynaud","sequence":"first","affiliation":[{"name":"Univ. Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, F-38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Bouchet-Spinelli","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, F-38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-5461","authenticated-orcid":false,"given":"Camille","family":"Raillon","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, F-38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-4305","authenticated-orcid":false,"given":"Arnaud","family":"Buhot","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, F-38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"ref_1","unstructured":"Coulter, W.H. (1953). Means for Counting Particles Suspended in a Fluid. (26,565,08A), U.S. Patent."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/225451a0","article-title":"Discreteness of Conductance Change in Bimolecular Lipid Membranes in the Presence of Certain Antibiotics","volume":"225","author":"Hladky","year":"1970","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13770","DOI":"10.1073\/pnas.93.24.13770","article-title":"Characterization of individual polynucleotide molecules using a membrane channel","volume":"93","author":"Kasianowicz","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/35084037","article-title":"Ion-beam sculpting at nanometre length scales","volume":"412","author":"Li","year":"2001","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.plrev.2012.05.010","article-title":"Nanopores: A journey towards DNA sequencing","volume":"9","author":"Wanunu","year":"2012","journal-title":"Phys. Life Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nmat965","article-title":"DNA molecules and configurations in a solid-state nanopore microscope","volume":"2","author":"Li","year":"2003","journal-title":"Nat. Mat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1021\/cb300449t","article-title":"Sensing Proteins through Nanopores: Fundamental to Applications","volume":"7","author":"Oukhaled","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"051903","DOI":"10.1103\/PhysRevE.71.051903","article-title":"Translocation of double-strand DNA through a silicon oxide nanopore","volume":"71","author":"Storm","year":"2005","journal-title":"Phys. Rev. E"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nnano.2016.267","article-title":"Real-time shape approximation and fingerprinting of single proteins using a nanopore","volume":"12","author":"Yusko","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12228","DOI":"10.1021\/acs.analchem.9b01900","article-title":"Precise DNA Concentration Measurements with Nanopores by Controlled Counting","volume":"91","author":"Charron","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1039\/C9AN00633H","article-title":"Nanopipettes: A potential tool for DNA detection","volume":"144","author":"Wang","year":"2019","journal-title":"Analyst"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nnano.2007.27","article-title":"Solid-state nanopores","volume":"2","author":"Dekker","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1039\/b813796j","article-title":"Nanopore analytics: Sensing of single molecules","volume":"38","author":"Howorka","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1039\/c0cs00053a","article-title":"Biomimetic smart nanopores and nanochannels","volume":"40","author":"Hou","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nbt.2181","article-title":"DNA sequencing with nanopores","volume":"30","author":"Schneider","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gracheva, M.E. (2012). Analyzing Single DNA Molecules by Nanopore Translocation. Nanopore-Based Technology, Humana Press. Methods in Molecular Biology.","DOI":"10.1007\/978-1-61779-773-6"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1039\/C2CS35286A","article-title":"Single molecule sensing with solid-state nanopores: Novel materials, methods, and applications","volume":"42","author":"Miles","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.2217\/nnm.13.145","article-title":"DNA origami nanopores: An emerging tool in biomedicine","volume":"8","author":"Keyser","year":"2013","journal-title":"Nanomedicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.nantod.2012.12.008","article-title":"Solid-State and Biological Nanopore for Real-Time Sensing of Single Chemical and Sequencing of DNA","volume":"8","author":"Haque","year":"2013","journal-title":"Nano Today"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.febslet.2014.06.013","article-title":"Nanopores formed by DNA origami: A review","volume":"588","author":"Bell","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.elecom.2014.03.007","article-title":"Electrochemical sensing with nanopores: A mini review","volume":"43","author":"Makra","year":"2014","journal-title":"Electrochem. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bios.2018.07.072","article-title":"Graphene-based nanopore approaches for DNA sequencing: A literature review","volume":"119","author":"Wasfi","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1039\/C8CS00106E","article-title":"Single-molecule protein sensing in a nanopore: A tutorial","volume":"47","author":"Varongchayakul","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1804878","DOI":"10.1002\/smll.201804878","article-title":"Biomolecule-Functionalized Solid-State Ion Nanochannels\/Nanopores: Features and Techniques","volume":"15","author":"Ding","year":"2019","journal-title":"Small"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/acsnano.9b09353","article-title":"Comparing Current Noise in Biological and Solid-State Nanopores","volume":"14","author":"Fragasso","year":"2020","journal-title":"ACS Nano"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Iqbal, S.M., and Bashir, R. (2011). Nanopores, Springer.","DOI":"10.1007\/978-1-4419-8252-0"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Branton, D., and Deamer, D. (2019). Nanopore Sequencing: An Introduction, World Scientific.","DOI":"10.1142\/10995"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.trac.2007.12.004","article-title":"Aptamer-based biosensors","volume":"27","author":"Song","year":"2008","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.anchem.1.031207.112851","article-title":"Applications of Aptamers as Sensors","volume":"2","author":"Cho","year":"2009","journal-title":"Annu. Rev. Anal. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.bbamem.2015.09.023","article-title":"Analytical applications for pore-forming proteins","volume":"1858","author":"Kasianowicz","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) Biomembr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrm.2016.147","article-title":"The nuclear pore complex: Understanding its function through structural insight","volume":"18","author":"Beck","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.274.5294.1859","article-title":"Structure of Staphylococcal \u03b1-Hemolysin, a Heptameric Transmembrane Pore","volume":"274","author":"Song","year":"1996","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1021\/acs.analchem.6b04260","article-title":"Nanopore Sensing","volume":"89","author":"Shi","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/nn506606e","article-title":"Resolved Single-Molecule Detection of Individual Species within a Mixture of anti-Biotin Antibodies Using an Engineered Monomeric Nanopore","volume":"9","author":"Fahie","year":"2015","journal-title":"ACS Nano"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ymeth.2016.03.026","article-title":"MspA nanopore as a single-molecule tool: From sequencing to SPRNT","volume":"105","author":"Laszlo","year":"2016","journal-title":"Methods"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41467-018-03418-2","article-title":"Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore","volume":"9","author":"Piguet","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-12690-9","article-title":"Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores","volume":"10","author":"Cao","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"18640","DOI":"10.1021\/jacs.7b10106","article-title":"Real-Time Conformational Changes and Controlled Orientation of Native Proteins Inside a Protein Nanoreactor","volume":"139","author":"Soskine","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1021\/acsnano.6b07760","article-title":"Label-Free and Real-Time Detection of Protein Ubiquitination with a Biological Nanopore","volume":"11","author":"Wloka","year":"2017","journal-title":"ACS Nano"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1021\/nn3001615","article-title":"Real-time sensing and discrimination of single chemicals using the channel of phi29 DNA packaging nanomotor","volume":"6","author":"Haque","year":"2012","journal-title":"ACS Nano"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1002\/smll.201601157","article-title":"Fingerprinting of Peptides with a Large Channel of Bacteriophage Phi29 DNA Packaging Motor","volume":"12","author":"Ji","year":"2016","journal-title":"Small"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.copbio.2017.11.006","article-title":"Engineering of protein nanopores for sequencing, chemical or protein sensing and disease diagnosis","volume":"51","author":"Wang","year":"2018","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Franssila, S. (2010). Introduction to Microfabrication, Wiley. [2nd ed.].","DOI":"10.1002\/9781119990413"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nmat941","article-title":"Fabrication of solid-state nanopores with single-nanometre precision","volume":"2","author":"Storm","year":"2003","journal-title":"Nat. Mat."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nnano.2016.120","article-title":"Reading the primary structure of a protein with 0.07 nm 3 resolution using a subnanometre-diameter pore","volume":"11","author":"Kennedy","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/s41596-019-0131-0","article-title":"Fabrication and practical applications of molybdenum disulfide nanopores","volume":"14","author":"Graf","year":"2019","journal-title":"Nat. Protoc."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kwok, H., Briggs, K., and Tabard-Cossa, V. (2014). Nanopore fabrication by controlled dielectric breakdown. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092880"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1038\/srep05000","article-title":"Fabricating nanopores with diameters of sub-1 nm to 3 nm using multilevel pulse-voltage injection","volume":"4","author":"Yanagi","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature09379","article-title":"Graphene as a subnanometre trans-electrode membrane","volume":"467","author":"Garaj","year":"2010","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1021\/nl101046t","article-title":"DNA Translocation through Graphene Nanopores","volume":"10","author":"Merchant","year":"2010","journal-title":"Nano Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"495301","DOI":"10.1088\/0957-4484\/27\/49\/495301","article-title":"Hydrophilic and size-controlled graphene nanopores for protein detection","volume":"27","author":"Goyal","year":"2016","journal-title":"Nanotechnology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.1002\/adfm.201601272","article-title":"Graphene Nanopores for Protein Sequencing","volume":"26","author":"Wilson","year":"2016","journal-title":"Adv. Funct. Mat."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"10121","DOI":"10.1021\/nn404326f","article-title":"Slow DNA Transport through Nanopores in Hafnium Oxide Membranes","volume":"7","author":"Larkin","year":"2013","journal-title":"ACS Nano"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1002\/elps.201400612","article-title":"Fabrication of solid-state nanopores and its perspectives","volume":"36","author":"Kudr","year":"2015","journal-title":"Electrophoresis"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"10090","DOI":"10.1021\/nn303816w","article-title":"Directly Observing the Motion of DNA Molecules near Solid-State Nanopores","volume":"6","author":"Ando","year":"2012","journal-title":"ACS Nano"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kubota, T., Lloyd, K., Sakashita, N., Minato, S., Ishida, K., and Mitsui, T. (2019). Clog and Release, and Reverse Motions of DNA in a Nanopore. Polymers, 11.","DOI":"10.3390\/polym11010084"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/nnano.2010.237","article-title":"Hybrid pore formation by directed insertion of \u03b1-haemolysin into solid-state nanopores","volume":"5","author":"Hall","year":"2010","journal-title":"Nat. Nanotechnol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"9582","DOI":"10.1039\/c3nr03683a","article-title":"Slow translocation of polynucleotides and their discrimination by \u03b1-hemolysin inside a single track-etched nanopore designed by atomic layer deposition","volume":"5","author":"Balme","year":"2013","journal-title":"Nanoscale"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1039\/C9SM01833F","article-title":"Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with \u03b1-hemolysin","volume":"16","author":"Bentin","year":"2020","journal-title":"Soft Matter"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nature07600","article-title":"Artificial nanopores that mimic the transport selectivity of the nuclear pore complex","volume":"457","author":"McKenney","year":"2009","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nnano.2011.88","article-title":"Single-molecule transport across an individual biomimetic nuclear pore complex","volume":"6","author":"Kowalczyk","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1038\/s41467-018-07116-x","article-title":"Thermostable virus portal proteins as reprogrammable adapters for solid-state nanopore sensors","volume":"9","author":"Cressiot","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.chempr.2017.02.009","article-title":"The Beauty and Utility of DNA Origami","volume":"2","author":"Wang","year":"2017","journal-title":"Chem"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1002\/anie.201200688","article-title":"DNA Origami Gatekeepers for Solid-State Nanopores","volume":"51","author":"Wei","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/nl204098n","article-title":"DNA Origami Nanopores","volume":"12","author":"Bell","year":"2012","journal-title":"Nano Lett."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1126\/science.1225624","article-title":"Synthetic lipid membrane channels formed by designed DNA nanostructures","volume":"338","author":"Langecker","year":"2012","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"14121","DOI":"10.1039\/C4NR04094E","article-title":"DNA origami nanopores: Developments, challenges and perspectives","volume":"6","author":"Keyser","year":"2014","journal-title":"Nanoscale"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nnano.2015.279","article-title":"A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane","volume":"11","author":"Burns","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/acsami.6b11001","article-title":"DNA Origami\u2013Graphene Hybrid Nanopore for DNA Detection","volume":"9","author":"Dibaeinia","year":"2017","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1021\/acs.jpcc.9b00399","article-title":"DNA Translocation through Hybrid Bilayer Nanopores","volume":"123","author":"Balasubramanian","year":"2019","journal-title":"J. Phys. Chem. C"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/nl070462b","article-title":"Chemically Modified Solid-State Nanopores","volume":"7","author":"Wanunu","year":"2007","journal-title":"Nano Lett."},{"key":"ref_72","first-page":"30","article-title":"Chemical Strategies for Generating Protein Biochips","volume":"47","author":"Jonkheijm","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nnano.2011.12","article-title":"Controlling protein translocation through nanopores with bio-inspired fluid walls","volume":"6","author":"Yusko","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"325504","DOI":"10.1088\/1361-6528\/ab19e6","article-title":"Fluid surface coatings for solid-state nanopores: Comparison of phospholipid bilayers and archaea-inspired lipid monolayers","volume":"30","author":"Eggenberger","year":"2019","journal-title":"Nanotechnology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"143105","DOI":"10.1063\/1.4964117","article-title":"Non-sticky translocation of bio-molecules through Tween 20-coated solid-state nanopores in a wide pH range","volume":"109","author":"Li","year":"2016","journal-title":"Appl. Phys. Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"495102","DOI":"10.1088\/0957-4484\/24\/49\/495102","article-title":"Surface modification of graphene nanopores for protein translocation","volume":"24","author":"Shan","year":"2013","journal-title":"Nanotechnology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"41634","DOI":"10.1021\/acsami.7b14717","article-title":"Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection","volume":"9","author":"Roman","year":"2017","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cis.2017.09.001","article-title":"Functionalization of single solid state nanopores to mimic biological ion channels: A review","volume":"250","author":"Lepoitevin","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"19636","DOI":"10.1039\/C9NR05367K","article-title":"Surface coatings for solid-state nanopores","volume":"11","author":"Eggenberger","year":"2019","journal-title":"Nanoscale"},{"key":"ref_80","unstructured":"(2020, May 08). Atomic Layer Deposition: An Overview\/Chemical Reviews. Available online: https:\/\/pubs.acs.org\/doi\/10.1021\/cr900056b."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/cvde.19950010103","article-title":"Chemical vapor deposition of metals: Part 1. An overview of CVD processes","volume":"1","author":"Kodas","year":"1995","journal-title":"Chem. Vapor Depos."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/nl103799d","article-title":"Polymeric Nanopore Membranes for Hydrophobicity-Based Separations by Conformal Initiated Chemical Vapor Deposition","volume":"11","author":"Asatekin","year":"2011","journal-title":"Nano Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1021\/nl0494001","article-title":"Atomic Layer Deposition to Fine-Tune the Surface Properties and Diameters of Fabricated Nanopores","volume":"4","author":"Chen","year":"2004","journal-title":"Nano Lett."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1021\/acs.analchem.5b01501","article-title":"Atomic Layer Deposition Modified Track-Etched Conical Nanochannels for Protein Sensing","volume":"87","author":"Wang","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1021\/acsnano.9b09964","article-title":"Lifetime and Stability of Silicon Nitride Nanopores and Nanopore Arrays for Ionic Measurements","volume":"14","author":"Chou","year":"2020","journal-title":"ACS Nano"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"12472","DOI":"10.1021\/acsnano.8b06805","article-title":"Photothermally Assisted Thinning of Silicon Nitride Membranes for Ultrathin Asymmetric Nanopores","volume":"12","author":"Yamazaki","year":"2018","journal-title":"ACS Nano"},{"key":"ref_87","first-page":"1","article-title":"Intrinsic and membrane-facilitated \u03b1-synuclein oligomerization revealed by label-free detection through solid-state nanopores","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms3619","article-title":"Tailoring the hydrophobicity of graphene for its use as nanopores for DNA translocation","volume":"4","author":"Schneider","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1021\/nl061681k","article-title":"Current Rectification with Poly-l-Lysine-Coated Quartz Nanopipettes","volume":"6","author":"Umehara","year":"2006","journal-title":"Nano Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1016\/j.bios.2011.05.010","article-title":"Reversible thrombin detection by aptamer functionalized STING sensors","volume":"26","author":"Actis","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.bios.2010.08.016","article-title":"UltraSensitive Mycotoxin Detection by STING Sensors","volume":"26","author":"Actis","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1021\/ma0703251","article-title":"Layer-by-Layer Assembly of Polyelectrolytes in Nanopores","volume":"40","author":"Alem","year":"2007","journal-title":"Macromolecules"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.1021\/ja101014y","article-title":"Layer-by-Layer Assembly of Polyelectrolytes into Ionic Current Rectifying Solid-State Nanopores: Insights from Theory and Experiment","volume":"132","author":"Ali","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1021\/acs.langmuir.8b00222","article-title":"Impact of Polyelectrolyte Multilayers on the Ionic Current Rectification of Conical Nanopores","volume":"34","author":"Ma","year":"2018","journal-title":"Langmuir"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"32228","DOI":"10.1039\/C6RA03698H","article-title":"Fast and reversible functionalization of a single nanopore based on layer-by-layer polyelectrolyte self-assembly for tuning current rectification and designing sensors","volume":"6","author":"Lepoitevin","year":"2016","journal-title":"RSC Adv."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1039\/C6FD00072J","article-title":"Protein detection using tunable pores: Resistive pulses and current rectification","volume":"193","author":"Blundell","year":"2016","journal-title":"Faraday Discuss."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1039\/C4CC09185J","article-title":"The facile surface chemical modification of a single glass nanopore and its use in the nonenzymatic detection of uric acid","volume":"51","author":"He","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nnano.2012.24","article-title":"Stochastic sensing of proteins with receptor-modified solid-state nanopores","volume":"7","author":"Wei","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1021\/ja043910f","article-title":"Protein Biosensors Based on Biofunctionalized Conical Gold Nanotubes","volume":"127","author":"Siwy","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1039\/C7NR09432A","article-title":"Polymer brushes in solid-state nanopores form an impenetrable entropic barrier for proteins","volume":"10","author":"Emilsson","year":"2018","journal-title":"Nanoscale"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/acscentsci.8b00268","article-title":"Gating Protein Transport in Solid State Nanopores by Single Molecule Recognition","volume":"4","author":"Emilsson","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/cphc.200900989","article-title":"Current Rectification in Temperature-Responsive Single Nanopores","volume":"11","author":"Guo","year":"2010","journal-title":"ChemPhysChem"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1705322","DOI":"10.1002\/adma.201705322","article-title":"It\u2019s Not a Bug, It\u2019s a Feature: Functional Materials in Insects","volume":"30","author":"Schroeder","year":"2018","journal-title":"Adv. Mat."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1021\/la00023a072","article-title":"Silanization of Solid Substrates: A Step Toward Reproducibility","volume":"10","author":"Brzoska","year":"1994","journal-title":"Langmuir"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"045006","DOI":"10.1088\/2043-6262\/6\/4\/045006","article-title":"Modification of silicon nitride surfaces with GOPES and APTES for antibody immobilization: Computational and experimental studies","volume":"6","author":"To","year":"2015","journal-title":"Adv. Nat. Sci. Nanosci. Nanotechnol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/adma.200501991","article-title":"Localized Functionalization of Single Nanopores","volume":"18","author":"Nilsson","year":"2006","journal-title":"Adv. Mat."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nnano.2007.78","article-title":"Solid-state nanopore channels with DNA selectivity","volume":"2","author":"Iqbal","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1021\/ac9006705","article-title":"Capturing Single Molecules of Immunoglobulin and Ricin with an Aptamer-Encoded Glass Nanopore","volume":"81","author":"Ding","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bios.2011.08.005","article-title":"\u201cDNA-Dressed NAnopore\u201d for complementary sequence detection","volume":"29","author":"Mussi","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.elecom.2018.09.017","article-title":"pH-modulated ion-current rectification in a cysteine-functionalized glass nanopipette","volume":"97","author":"Liu","year":"2018","journal-title":"Electrochem. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6822","DOI":"10.1021\/nn501331u","article-title":"Amplification of Single Molecule Translocation Signal Using \u03b2-Strand Peptide Functionalized Nanopores","volume":"8","author":"Rapaport","year":"2014","journal-title":"ACS Nano"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.elecom.2019.01.008","article-title":"Detection of alkaline phosphatase activity with a functionalized nanopipette","volume":"99","author":"Zhang","year":"2019","journal-title":"Electrochem. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/adfm.201002627","article-title":"Smart Homopolymer Modification to Single Glass Conical Nanopore Channels: Dual-Stimuli-Actuated Highly Efficient Ion Gating","volume":"21","author":"Zhang","year":"2011","journal-title":"Adv. Funct. Mat."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Fu, Y., Tokuhisa, H., and Baker, L.A. (2009). Nanopore DNA sensors based on dendrimer-modified nanopipettes. Chem. Commun., 4877\u20134879.","DOI":"10.1039\/b910511e"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1126\/science.1071396","article-title":"Antibody-Based Bio-Nanotube Membranes for Enantiomeric Drug Separations","volume":"296","author":"Lee","year":"2002","journal-title":"Science"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"13553","DOI":"10.1021\/ja064274j","article-title":"Photon Gated Transport at the Glass Nanopore Electrode","volume":"128","author":"Wang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1703357","DOI":"10.1002\/smll.201703357","article-title":"Reversible Immobilization of Proteins in Sensors and Solid-State Nanopores","volume":"14","author":"Ananth","year":"2018","journal-title":"Small"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/smll.200900482","article-title":"Contactless Electrofunctionalization of a Single Pore","volume":"5","author":"Bouchet","year":"2009","journal-title":"Small"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/ac2033744","article-title":"Polarization-Induced Local Pore-Wall Functionalization for Biosensing: From Micropore to Nanopore","volume":"84","author":"Liu","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1021\/acs.analchem.9b00559","article-title":"Enhanced Bipolar Electrochemistry at Solid-State Micropores: Demonstration by Wireless Electrochemiluminescence Imaging","volume":"91","author":"Ismail","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Bouchet-Spinelli, A., Descamps, E., Liu, J., Ismail, A., Pham, P., Chatelain, F., Le\u00efchl\u00e9, T., Leroy, L., Marche, P.N., and Raillon, C. (2019). Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology. Biosensors, 9.","DOI":"10.3390\/bios9040121"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.trac.2019.04.014","article-title":"Functional solid-state nanochannels for biochemical sensing","volume":"115","author":"Ma","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1002\/anie.200500196","article-title":"Trapping of Proteins under Physiological Conditions in a Nanopipette","volume":"44","author":"Clarke","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1021\/nl100997s","article-title":"Detecting DNA Folding with Nanocapillaries","volume":"10","author":"Steinbock","year":"2010","journal-title":"Nano Lett."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/nl400304y","article-title":"Controllable Shrinking and Shaping of Glass Nanocapillaries under Electron Irradiation","volume":"13","author":"Steinbock","year":"2013","journal-title":"Nano Lett."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1021\/nn4004567","article-title":"Single Protein Molecule Detection by Glass Nanopores","volume":"7","author":"Li","year":"2013","journal-title":"ACS Nano"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1021\/ac500184z","article-title":"Calibration-Less Sizing and Quantitation of Polymeric Nanoparticles and Viruses with Quartz Nanopipets","volume":"86","author":"Makra","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1039\/C5AN01001B","article-title":"Fine tuning of nanopipettes using atomic layer deposition for single molecule sensing","volume":"140","author":"Sze","year":"2015","journal-title":"Analyst"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1021\/acs.analchem.5b02540","article-title":"Selective Detection of Single-Stranded DNA Molecules Using a Glass Nanocapillary Functionalized with DNA","volume":"88","author":"Youn","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7679","DOI":"10.1021\/ja061357r","article-title":"Electrostatic-Gated Transport in Chemically Modified Glass Nanopore Electrodes","volume":"128","author":"Wang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1021\/acs.nanolett.6b04165","article-title":"Single Molecule Localization and Discrimination of DNA\u2013Protein Complexes by Controlled Translocation Through Nanocapillaries","volume":"16","author":"Bulushev","year":"2016","journal-title":"Nano Lett."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1021\/nn9010768","article-title":"In Situ Intracellular Spectroscopy with Surface Enhanced Raman Spectroscopy (SERS)-Enabled Nanopipettes","volume":"3","author":"Vitol","year":"2009","journal-title":"ACS Nano"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.2200121","article-title":"Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase","volume":"249","author":"Tuerk","year":"1990","journal-title":"Science"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/346818a0","article-title":"In vitro selection of RNA molecules that bind specific ligands","volume":"346","author":"Ellington","year":"1990","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/microarrays4010041","article-title":"Gold Nanoparticles Surface Plasmon Resonance Enhanced Signal for the Detection of Small Molecules on Split-Aptamer Microarrays","volume":"4","author":"Melaine","year":"2015","journal-title":"Microarrays"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"16947","DOI":"10.1039\/C6NR04868D","article-title":"A nanoparticle-based thermo-dynamic aptasensor for small molecule detection","volume":"8","author":"Melaine","year":"2016","journal-title":"Nanoscale"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bios.2012.07.016","article-title":"Real time monitoring of thrombin interactions with its aptamers: Insights into the sandwich complex formation","volume":"40","author":"Daniel","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Daniel, C., Roupioz, Y., Gasparutto, D., Livache, T., and Buhot, A. (2013). Solution-Phase vs Surface-Phase Aptamer-Protein Affinity from a Label-Free Kinetic Biosensor. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075419"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1021\/jp0775911","article-title":"Encapsulating a Single G-Quadruplex Aptamer in a Protein Nanocavity","volume":"112","author":"Shim","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"12826","DOI":"10.1021\/nn506077e","article-title":"Detection of Two Isomeric Binding Configurations in a Protein\u2013Aptamer Complex with a Biological Nanopore","volume":"8","author":"Soskine","year":"2014","journal-title":"ACS Nano"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.bpj.2013.07.047","article-title":"Nanopore Force Spectroscopy of Aptamer\u2013Ligand Complexes","volume":"105","author":"Arnaut","year":"2013","journal-title":"Biophys. J."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Winters-Hilt, S., Davis, A., Amin, I., and Morales, E. (2007). Nanopore current transduction analysis of protein binding to non-terminal and terminal DNA regions: Analysis of transcription factor binding, retroviral DNA terminus dynamics, and retroviral integrase-DNA binding. BMC Bioinform., 8.","DOI":"10.1186\/1471-2105-8-S7-S10"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Thomson, K., Amin, I., Morales, E., and Winters-Hilt, S. (2007). Preliminary nanopore cheminformatics analysis of aptamer-target binding strength. BMC Bioinform., 8.","DOI":"10.1186\/1471-2105-8-S7-S11"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1039\/B907735A","article-title":"Single molecule sensing by nanopores and nanopore devices","volume":"135","author":"Gu","year":"2010","journal-title":"Analyst"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/smll.200901435","article-title":"Nanopore Translocation and Force Spectroscopy Experiments in Microemulsion Droplets","volume":"6","author":"Renner","year":"2010","journal-title":"Small"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ymeth.2012.03.026","article-title":"Single-molecule investigation of G-quadruplex using a nanopore sensor","volume":"57","author":"Shim","year":"2012","journal-title":"Methods"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/nar\/gkn968","article-title":"Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity","volume":"37","author":"Shim","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1021\/jp411820w","article-title":"3D Structural Integrity and Interactions of Single-Stranded Protein-Binding DNA in a Functionalized Nanopore","volume":"118","author":"Mahmood","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1021\/ac401764c","article-title":"Monitoring Aptamer\u2013Protein Interactions Using Tunable Resistive Pulse Sensing","volume":"86","author":"Billinge","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.elecom.2017.05.018","article-title":"Label-free monitoring of the thrombin\u2013aptamer recognition reaction using an array of nanochannels coupled with electrochemical detection","volume":"81","author":"Zhao","year":"2017","journal-title":"Electrochem. Commun."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1021\/ja3043646","article-title":"Engineering a Rigid Protein Tunnel for Biomolecular Detection","volume":"134","author":"Mohammad","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/smll.201001428","article-title":"Monitoring of an ATP-Binding Aptamer and its Conformational Changes Using an \u03b1-Hemolysin Nanopore","volume":"7","author":"Ying","year":"2011","journal-title":"Small"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1039\/c4sc00134f","article-title":"Single molecule analysis of light-regulated RNA:spiropyran interactions","volume":"5","author":"Zhang","year":"2014","journal-title":"Chem. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00604-015-1699-x","article-title":"Single-molecule analysis of lead (II)-binding aptamer conformational changes in an \u03b1-hemolysin nanopore, and sensitive detection of lead (II)","volume":"183","author":"Wang","year":"2016","journal-title":"Microchim. Acta"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1021\/acsnano.8b01583","article-title":"The Design and Characterization of Multifunctional Aptamer Nanopore Sensors","volume":"12","author":"Mayne","year":"2018","journal-title":"ACS Nano"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"8474","DOI":"10.1021\/ja2026085","article-title":"Rapid Detection of a Cocaine-Binding Aptamer Using Biological Nanopores on a Chip","volume":"133","author":"Kawano","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/s41467-017-01584-3","article-title":"Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers","volume":"8","author":"Sze","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1021\/acs.analchem.5b00791","article-title":"Label-Free Nanopore Proximity Bioassay for Platelet-Derived Growth Factor Detection","volume":"87","author":"Zhang","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1002\/anie.201502047","article-title":"A Universal Strategy for Aptamer-Based Nanopore Sensing through Host\u2013Guest Interactions inside \u03b1-Hemolysin","volume":"54","author":"Li","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1021\/nn400125c","article-title":"Sampling a Biomarker of the Human Immunodeficiency Virus across a Synthetic Nanopore","volume":"7","author":"Niedzwiecki","year":"2013","journal-title":"ACS Nano"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.1039\/C4NR02062F","article-title":"DNA-based detection of mercury (II) ions through characteristic current signals in nanopores with high sensitivity and selectivity","volume":"6","author":"Zeng","year":"2014","journal-title":"Nanoscale"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bios.2014.07.062","article-title":"PEI\/Zr4+-coated nanopore for selective and sensitive detection of ATP in combination with single-walled carbon nanotubes","volume":"63","author":"Zhang","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Kawano, R., Osaki, T., Sasaki, H., Takinoue, M., Yoshizawa, S., and Takeuchi, S. (2011, January 23\u201327). 25 second cocaine sensing by membrane protein channel integrated in a microfluidic device. Proceedings of the 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, Cancun, Mexico.","DOI":"10.1109\/MEMSYS.2011.5734680"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/acssensors.6b00627","article-title":"Label-Free Nanopore Biosensor for Rapid and Highly Sensitive Cocaine Detection in Complex Biological Fluids","volume":"2","author":"Rauf","year":"2017","journal-title":"ACS Sens."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Nobukawa, A., Osaki, T., Tonooka, T., Morimoto, Y., and Takeuchi, S. (2015, January 18\u201322). Electrical detection of pesticide vapors by biological nanopores with DNA aptamers. Proceedings of the 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Estoril, Portugal.","DOI":"10.1109\/MEMSYS.2015.7051026"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Fujii, S., Misawa, N., Kamiya, K., Osaki, T., and Takeuchi, S. (2018, January 21\u201325). Breathable fabric meets a lipid bilayer system for rapid vapor detection. Proceedings of the 2018 IEEE Micro Electro Mechanical Systems (MEMS), Belfast, Ireland.","DOI":"10.1109\/MEMSYS.2018.8346538"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1039\/C7LC00361G","article-title":"Pesticide vapor sensing using an aptamer, nanopore, and agarose gel on a chip","volume":"17","author":"Fujii","year":"2017","journal-title":"Lab Chip"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1021\/ja512521w","article-title":"Specific Protein Detection Using Designed DNA Carriers and Nanopores","volume":"137","author":"Bell","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1021\/acssensors.7b00628","article-title":"Identifying Structure in Short DNA Scaffolds Using Solid-State Nanopores","volume":"2","author":"Beamish","year":"2017","journal-title":"ACS Sens."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1807555","DOI":"10.1002\/adfm.201807555","article-title":"Specific Biosensing Using DNA Aptamers and Nanopores","volume":"29","author":"Kong","year":"2019","journal-title":"Adv. Funct. Mat."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"11955","DOI":"10.1039\/C8NR03168A","article-title":"Nanopore based detection of Bacillus thuringiensis HD-73 spores using aptamers and versatile DNA hairpins","volume":"10","author":"Park","year":"2018","journal-title":"Nanoscale"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.bios.2015.02.011","article-title":"Multiplexed, label-free detection of biomarkers using aptamers and Tunable Resistive Pulse Sensing (AptaTRPS)","volume":"68","author":"Billinge","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1021\/acs.analchem.7b04584","article-title":"Ultrasensitive Detection of Cancer Cells Combining Enzymatic Signal Amplification with an Aerolysin Nanopore","volume":"90","author":"Xi","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/smll.201200058","article-title":"Resistive Pulse Sensing of Analyte-Induced Multicomponent Rod Aggregation Using Tunable Pores","volume":"8","author":"Platt","year":"2012","journal-title":"Small"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"8534","DOI":"10.1039\/C5AY01655J","article-title":"Aptamer based dispersion assay using tunable resistive pulse sensing (TRPS)","volume":"7","author":"Billinge","year":"2015","journal-title":"Anal. Methods"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1039\/C7SC00415J","article-title":"Selective single molecule nanopore sensing of proteins using DNA aptamer-functionalised gold nanoparticles","volume":"8","author":"Lin","year":"2017","journal-title":"Chem. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bios.2014.02.004","article-title":"Small molecule detection in solution via the size contraction response of aptamer functionalized nanoparticles","volume":"57","author":"Alsager","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"14825","DOI":"10.1021\/acs.langmuir.8b00945","article-title":"Label-Free Sensitive Detection of Microcystin-LR via Aptamer-Conjugated Gold Nanoparticles Based on Solid-State Nanopores","volume":"34","author":"He","year":"2018","journal-title":"Langmuir"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1039\/D0AN00063A","article-title":"Rapid quantification of prion proteins using resistive pulse sensing","volume":"145","author":"Healey","year":"2020","journal-title":"Analyst"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1021\/acs.analchem.9b04185","article-title":"Nanopore-based Strategy for Selective Detection of Single Carcinoembryonic Antigen (CEA) Molecules","volume":"92","author":"Tang","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1021\/acs.analchem.9b02965","article-title":"Unambiguous Discrimination of Multiple Protein Biomarkers by Nanopore Sensing with Double-Stranded DNA-Based Probes","volume":"92","author":"Fang","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"10850","DOI":"10.1021\/ja047675c","article-title":"Conical-Nanotube Ion-Current Rectifiers:\u2009 The Role of Surface Charge","volume":"126","author":"Siwy","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"18739","DOI":"10.1021\/jacs.7b11732","article-title":"On the Origin of Ionic Rectification in DNA-Stuffed Nanopores: The Breaking and Retrieving Symmetry","volume":"139","author":"Jiang","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"14597","DOI":"10.1021\/acs.analchem.9b03685","article-title":"On Rectification of Ionic Current in Nanopores","volume":"91","author":"Wen","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bios.2015.04.002","article-title":"Surface charge modulated aptasensor in a single glass conical nanopore","volume":"71","author":"Cai","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1039\/C5CC00257E","article-title":"Bioconjugation-induced ionic current rectification in aptamer-modified single cylindrical nanopores","volume":"51","author":"Ali","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"112011","DOI":"10.1016\/j.bios.2020.112011","article-title":"Ultrasensitive and regenerable nanopore sensing based on target induced aptamer dissociation","volume":"152","author":"Zhang","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"10183","DOI":"10.1109\/JSEN.2018.2872853","article-title":"Intelligent Quantification of Picomolar Protein Concentration in Serum by Functionalized Nanopores","volume":"18","author":"Das","year":"2018","journal-title":"IEEE Sens. J."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1021\/acs.analchem.8b05162","article-title":"Nanochannel\u2013Ion Channel Hybrid Device for Ultrasensitive Monitoring of Biomolecular Recognition Events","volume":"91","author":"Zhao","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Varga, M., B\u00e9rczes, Z., Ill\u00e9s, L., S\u00e1fr\u00e1ny, G., B\u00e1rsony, I., F\u00fcrjes, P., Gyurcs\u00e1nyi, R.E., and J\u00e1gerszki, G. (2014, January 2\u20135). Fluidically and electrically integrated solid state nanopore arrays for biochemical sensing. Proceedings of the 2014 IEEE SENSORS, Valencia, Spain.","DOI":"10.1109\/ICSENS.2014.6985138"},{"key":"ref_191","unstructured":"Gu, L.-Q., Ding, S., and Gao, C. (2009, January 3\u20136). Aptamer-encoded nanopore for ultrasensitive detection of bioterrorist agent ricin at single-molecule resolution. Proceedings of the 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, USA."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1039\/c0cc02649b","article-title":"Biomimetic glass nanopores employing aptamer gates responsive to a small molecule","volume":"46","author":"Abelow","year":"2010","journal-title":"Chem. Commun."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1021\/acsami.7b16539","article-title":"Single Nanochannel-Aptamer-Based Biosensor for Ultrasensitive and Selective Cocaine Detection","volume":"10","author":"Wang","year":"2018","journal-title":"ACS Appl. Mat. Interfaces"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cbpa.2013.10.023","article-title":"Advances in DNA-directed immobilization","volume":"18","author":"Meyer","year":"2014","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/anie.201209162","article-title":"Two-Way Nanopore Sensing of Sequence-Specific Oligonucleotides and Small-Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures","volume":"52","author":"Liu","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1021\/ac502752g","article-title":"Quantitative Detection of Potassium Ions and Adenosine Triphosphate via a Nanochannel-Based Electrochemical Platform Coupled with G-Quadruplex Aptamers","volume":"86","author":"Yu","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1021\/acs.analchem.5b00375","article-title":"Nanopore-Based DNA-Probe Sequence-Evolution Method Unveiling Characteristics of Protein\u2013DNA Binding Phenomena in a Nanoscale Confined Space","volume":"87","author":"Liu","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1021\/ja2105653","article-title":"Protein Detection by Nanopores Equipped with Aptamers","volume":"134","author":"Rotem","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1021\/nl3024438","article-title":"An Engineered ClyA Nanopore Detects Folded Target Proteins by Selective External Association and Pore Entry","volume":"12","author":"Soskine","year":"2012","journal-title":"Nano Lett."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"9911","DOI":"10.1021\/acs.analchem.7b02147","article-title":"Nanopipette-Based SERS Aptasensor for Subcellular Localization of Cancer Biomarker in Single Cells","volume":"89","author":"Hanif","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"15395","DOI":"10.1021\/ja3053333","article-title":"Highly-Efficient Gating of Solid-State Nanochannels by DNA Supersandwich Structure Containing ATP Aptamers: A Nanofluidic IMPLICATION Logic Device","volume":"134","author":"Jiang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"eaav2568","DOI":"10.1126\/sciadv.aav2568","article-title":"Biomimetic potassium-selective nanopores","volume":"5","author":"Acar","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/smll.201503863","article-title":"Adenosine-Activated Nanochannels Inspired by G-Protein-Coupled Receptors","volume":"12","author":"Li","year":"2016","journal-title":"Small"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/cphc.201700982","article-title":"Synthetic Ion Channels and DNA Logic Gates as Components of Molecular Robots","volume":"19","author":"Kawano","year":"2018","journal-title":"Chem. Phys. Chem."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature18593","article-title":"Single-layer MoS 2 nanopores as nanopower generators","volume":"536","author":"Feng","year":"2016","journal-title":"Nature"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.1002\/anie.201600438","article-title":"Two-Dimensional-Material Membranes: A New Family of High-Performance Separation Membranes","volume":"55","author":"Liu","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nnano.2017.72","article-title":"Fundamental transport mechanisms, fabrication and potential applications of nanoporous atomically thin membranes","volume":"12","author":"Wang","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nnano.2015.37","article-title":"Water desalination using nanoporous single-layer graphene","volume":"10","author":"Surwade","year":"2015","journal-title":"Nat. Nanotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1038\/ncomms9616","article-title":"Water desalination with a single-layer MoS 2 nanopore","volume":"6","author":"Heiranian","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.aau5321","article-title":"Large-area graphene-nanomesh\/carbon-nanotube hybrid membranes for ionic and molecular nanofiltration","volume":"364","author":"Yang","year":"2019","journal-title":"Science"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"15115","DOI":"10.1039\/C6NR04508A","article-title":"2D nanostructures for water purification: Graphene and beyond","volume":"8","author":"Dervin","year":"2016","journal-title":"Nanoscale"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1039\/C7CS00688H","article-title":"Bioinspired smart asymmetric nanochannel membranes","volume":"47","author":"Zhang","year":"2018","journal-title":"Chem. Soc. Rev."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/16\/4495\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:59:19Z","timestamp":1760176759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/16\/4495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":212,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["s20164495"],"URL":"https:\/\/doi.org\/10.3390\/s20164495","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]}}}