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The incidence of AD is growing yearly as life expectancy increases, thus early detection is essential to ensure a better quality of life for diagnosed patients. To reach that purpose, electrochemical biosensing has emerged as a cost-effective alternative to traditional diagnostic techniques, due to its high sensitivity and selectivity. Of special relevance is the incorporation of nanomaterials in biosensors, as they contribute to enhance electron transfer while promoting the immobilization of biological recognition elements. Moreover, nanomaterials have also been employed as labels, due to their unique electroactive and electrocatalytic properties. The aim of this review is to add value in the advances achieved in the detection of AD biomarkers, the strategies followed for the incorporation of nanomaterials and its effect in biosensors performance.<\/jats:p>","DOI":"10.3390\/s20174748","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T21:28:06Z","timestamp":1598218086000},"page":"4748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Electrochemical Biosensors Based on Nanomaterials for Early Detection of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-2578","authenticated-orcid":false,"given":"Celia","family":"Toyos-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"NanoBioAnalysis Group-Department of Physical and Analytical Chemistry, University of Oviedo, Juli\u00e1n Claver\u00eda 8, 33006 Oviedo, Spain"},{"name":"Biotechnology Institute of Asturias, University of Oviedo, Santiago Gascon Building, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Garc\u00eda-Alonso","sequence":"additional","affiliation":[{"name":"Biotechnology Institute of Asturias, University of Oviedo, Santiago Gascon Building, 33006 Oviedo, Spain"},{"name":"NanoBioAnalysis Group-Department of Organic and Inorganic Chemistry, University of Oviedo, Juli\u00e1n Claver\u00eda 8, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-0253","authenticated-orcid":false,"given":"Alfredo","family":"de la Escosura-Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"NanoBioAnalysis Group-Department of Physical and Analytical Chemistry, University of Oviedo, Juli\u00e1n Claver\u00eda 8, 33006 Oviedo, Spain"},{"name":"Biotechnology Institute of Asturias, University of Oviedo, Santiago Gascon Building, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer\u2019s disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"ref_2","unstructured":"Alzheimer\u2019s Disease International (2019). 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