{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:11:55Z","timestamp":1785175915624,"version":"3.55.0"},"reference-count":48,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51950410598"],"award-info":[{"award-number":["51950410598"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Science and Technology Innovation Committee","award":["JCYJ20170412154426330"],"award-info":[{"award-number":["JCYJ20170412154426330"]}]},{"name":"Guangdong Natural Science Funds","award":["2016A030306042 and 2018A050506001"],"award-info":[{"award-number":["2016A030306042 and 2018A050506001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this work, we demonstrate the incorporation of two-dimensional (2D) layered materials into a metal\u2013organic framework (MOF) derived from one-dimensional (1D) cerium oxide (CeO2) for the electrochemical detection of dopamine. Ce-MOF was employed as a sacrificial template for preparing CeO2 with 2D materials by the pyrolysis process. The influence of the pyrolysis temperature was studied to achieve a better crystal structure of CeO2. Siloxene improved the dopamine sensing performance of CeO2 compared with graphitic carbon nitride (g-C3N4) due to the basal plane surface oxygen and hydroxyl groups of 2D siloxene. Under optimal conditions, the fabricated CeO2\/siloxene electrode exhibited a detection limit of 0.292 \u03bcM, with a linear range from 0.292 \u03bcM to 7.8 \u03bcM. This work provides a novel scheme for designing the CeO2 material with siloxene for excellent dopamine sensors, which could be extended towards other biosensing applications.<\/jats:p>","DOI":"10.3390\/s20174880","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:17:08Z","timestamp":1598606228000},"page":"4880","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["CeO2-Based Two-Dimensional Layered Nanocomposites Derived from a Metal\u2013Organic Framework for Selective Electrochemical Dopamine Sensors"],"prefix":"10.3390","volume":"20","author":[{"given":"Chengjie","family":"Ge","sequence":"first","affiliation":[{"name":"School of Microelectronics, Southern University of Science and Technology, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendran","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Southern University of Science and Technology, Shenzhen 518055, China"},{"name":"SUSTech Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-1022","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Microelectronics, Southern University of Science and Technology, Shenzhen 518055, China"},{"name":"Engineering Research Center of Integrated Circuits for Next-Generation Communications, Ministry of Education, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"769A","DOI":"10.1021\/ac00164a001","article-title":"Detection of dopamine dynamics in the brain","volume":"60","author":"Wightman","year":"1988","journal-title":"Anal. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jelechem.2017.01.012","article-title":"A facile electrochemical sensor based on well-dispersed graphene-molybdenum disulfide modified electrode for highly sensitive detection of dopamine","volume":"786","author":"Cheng","year":"2017","journal-title":"J. Electroanal. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1039\/C3TB21079K","article-title":"Organic electrodes for highly sensitive and selective dopamine sensors","volume":"2","author":"Liao","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"135066","DOI":"10.1016\/j.electacta.2019.135066","article-title":"A highly flexible and selective dopamine sensor based on Pt-Au nanoparticle-modified laser-induced graphene","volume":"328","author":"Hui","year":"2019","journal-title":"Electrochim. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jelechem.2018.09.014","article-title":"A dopamine electrochemical sensor based on Pd-Pt alloy nanoparticles decorated polyoxometalate and multiwalled carbon nanotubes","volume":"827","author":"Jiao","year":"2018","journal-title":"J. Electroanal. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/nprot.2016.071","article-title":"Electrochemical detection of nucleic acids, proteins, small molecules and cells using a DNA-nanostructure-based universal biosensing platform","volume":"11","author":"Lin","year":"2016","journal-title":"Nat. Protoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1021\/acs.analchem.5b04795","article-title":"Poly(A) Extensions of miRNAs for Amplification-Free Electrochemical Detection on Screen-Printed Gold Electrodes","volume":"88","author":"Koo","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bios.2016.09.016","article-title":"Detection of regional DNA methylation using DNA-graphene affinity interactions","volume":"87","author":"Haque","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/tp.2014.133","article-title":"Dopaminergic function and intertemporal choice","volume":"5","author":"Joutsa","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrneurol.2013.57","article-title":"The role of neuroplasticity in dopaminergic therapy for Parkinson disease","volume":"9","author":"Zhuang","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"134771","DOI":"10.1016\/j.electacta.2019.134771","article-title":"Porous nickel oxide microsphere and Ti3C2Tx hybrid derived from metal-organic framework for battery-type supercapacitor electrode and non-enzymatic H2O2 sensor","volume":"322","author":"Ramachandran","year":"2019","journal-title":"Electrochim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1002\/anie.201308625","article-title":"Ultralight Mesoporous Magnetic Frameworks by Interfacial Assembly of Prussian Blue Nanocubes","volume":"53","author":"Kong","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1002\/adma.201500789","article-title":"Well-Defined Metal-Organic-Framework Hollow Nanostructures for Catalytic Reactions in Volving Gases","volume":"27","author":"Xu","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1039\/C6TA09030C","article-title":"MOF-Derived Bi-Metal Embedded N-Doped Carbon Polyhedral Nanocages with Enhanced Lithium Storage","volume":"5","author":"Huang","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1021\/jacs.7b01942","article-title":"General Oriented Formation of Carbon Nanotubes from Metal-Organic Frameworks","volume":"139","author":"Meng","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1039\/C6CS00724D","article-title":"Metal-Organic Frameworks Meet Metal Nanoparticles: Synergistic Effect for Enhanced Catalysis","volume":"46","author":"Yang","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1002\/adma.201506315","article-title":"Formation of Prussian-Blue-Analog Nanocages via a Direct Etching Method and Their Conversion into Ni-Co-Mixed Oxide for Enhanced Oxygen Evolution","volume":"28","author":"Han","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15394","DOI":"10.1021\/acsami.7b01082","article-title":"Metal-Organic Framework Derivatives for Improving the Catalytic Activity of the CO Oxidation Reaction","volume":"9","author":"Ji","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/smll.201401791","article-title":"Well-Dispersed and Size-Controlled Supported Metal Oxide Nano-particles Derived from MOF Composites and Further Application in Catalysis","volume":"11","author":"Liu","year":"2015","journal-title":"Small"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1039\/C9QI01268K","article-title":"Recent progress on metal\u2013organic frameworkderived materials for sodium-ion battery anodes","volume":"3","author":"Chen","year":"2020","journal-title":"Inorg. Chem. Front."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.matchemphys.2019.01.057","article-title":"CeO2-CuO bimetal oxides derived from Ce-based MOF and their difference in catalytic activities for CO oxidation","volume":"26","author":"Guo","year":"2019","journal-title":"Mater. Chem. Phys."},{"key":"ref_22","first-page":"6754","article-title":"Metal-organic framework derived hollow materials for electrochemical energy storage","volume":"7","author":"Xie","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"122670","DOI":"10.1016\/j.cej.2019.122670","article-title":"MOF-derived CoN\/N-C@SiO2 yolk-shell nanoreactor with dual active sites for highly efficient catalytic advanced oxidation processes","volume":"381","author":"Zhang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.matchemphys.2008.12.031","article-title":"Synthesis, structural and optical properties of CeO2 nanoparticles synthesized by a simple polyvinyl pyrrolidone (PVP) solution route","volume":"115","author":"Phoka","year":"2019","journal-title":"Mater. Chem. Phys."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dhall, A., and Self, W. (2018). Cerium oxide nanoparticles: A brief review of their synthesis methods and biomedical applications. Antioxidants, 7.","DOI":"10.3390\/antiox7080097"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jcis.2011.01.063","article-title":"Fabrication of cerium oxide nanoparticles: Characterizations and optical properties","volume":"356","author":"Goharshadi","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100477","DOI":"10.1016\/j.apmt.2019.100477","article-title":"2D siloxene sheets: A novel electrochemical sensor for selective dopamine detection","volume":"18","author":"Ramachandran","year":"2019","journal-title":"Appl. Mater. Today"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1007\/s10570-020-02994-1","article-title":"One-pot synthesis of HMF from carbohydrates over acid-base bi-functional carbonaceous catalyst supported on halloysite nanotubes","volume":"27","author":"Zhang","year":"2020","journal-title":"Cellulose"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cej.2017.08.131","article-title":"Fabrication of magnetically recoverable photocatalysts using g-C3N4 for effective separation of charge carriers through like-Z-scheme mechanism with Fe3O4 mediator","volume":"331","author":"Zhu","year":"2018","journal-title":"Chem. Eng. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.apsusc.2014.05.036","article-title":"Enhanced visible light photocatalytic performance of g-C3N4 photocatalysts Co-doped with iron and phosphorus","volume":"311","author":"Hu","year":"2014","journal-title":"Appl. Surf. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cej.2017.04.107","article-title":"Enhancing the catalytic activity of g-C3N4 through Me doping (Me = Cu, Co and Fe) for selective sulfathiazole degradation via redox-based advanced oxidation process","volume":"323","author":"Oh","year":"2017","journal-title":"Chem. Eng. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101552","DOI":"10.1039\/C5RA19586A","article-title":"Synthesis of g-C3N4 at different temperatures for superior visible\/UV photocatalytic performance and photoelectrochemical sensing of MB solution","volume":"5","author":"Mo","year":"2015","journal-title":"RSC Adv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.carbon.2018.01.008","article-title":"An ultrasensitive electrochemical sensor based on 2D g-C3N4\/CuO nanocomposites for dopamine detection","volume":"130","author":"Zou","year":"2018","journal-title":"Carbon"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1039\/C8AN02110D","article-title":"Emerging trends in sensors based on carbon nitride materials","volume":"144","author":"Xavier","year":"2019","journal-title":"Analyst"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.jece.2018.04.009","article-title":"Photocatalytic properties of copper-two dimensional graphitic carbon nitride hybrid film synthesized by pyrolysis method","volume":"6","author":"Sakthivel","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1039\/C7RA12789H","article-title":"Enhanced electrochemical properties of cerium metal\u2013organic framework based composite electrodes for high-performance supercapacitor application","volume":"8","author":"Ramachandran","year":"2018","journal-title":"RSC Adv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cej.2018.03.091","article-title":"In situ pyrolysis of Ce-MOF to prepare CeO2 catalyst with obviously improved catalytic performance for toluene combustion","volume":"334","author":"Chen","year":"2018","journal-title":"Chem. Eng. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcis.2016.10.024","article-title":"A simple preparation of graphite\/gelatin composite for electrochemical detection of dopamine","volume":"487","author":"Rajkumar","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00604-018-2898-z","article-title":"Electrochemical dopamine sensor using a nanoporous gold microelectrode: A proof-of-concept study for the detection of dopamine release by scanning electrochemical microscopy","volume":"185","author":"Saenz","year":"2018","journal-title":"Microchim. Acta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aca.2019.10.059","article-title":"Ultrasound treated cerium oxide\/tin oxide (CeO2\/SnO2) nanocatalyst: A feasible approach and enhanced electrode material for sensing of anti-inflammatory drug 5-aminosalicylic acid in biological samples","volume":"1096","author":"Sukanya","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jtice.2020.05.002","article-title":"One-pot sonochemical synthesis of marigold flower-like structured ruthenium doped bismuth sulfide for the highly sensitive detection of antipsychotic drug thioridazine in the human serum sample","volume":"111","author":"Sakthivel","year":"2020","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"118646","DOI":"10.1016\/j.apcatb.2020.118646","article-title":"DPV-assisted understanding of TiO2 photocatalytic decomposition of aspirin by identifying the role of produced reactive species","volume":"266","author":"Vali","year":"2020","journal-title":"Appl. Catal. B Environ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.snb.2008.02.039","article-title":"Bean sprout peroxidase biosensor based on l-cysteine self-assembled monolayer for the determination of dopamine","volume":"133","author":"Moccelini","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bios.2015.11.061","article-title":"Dopamine biosensor based on surface functionalized nanostructured nickel oxide platform","volume":"84","author":"Roychoudhury","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.msec.2016.11.127","article-title":"Novel impedimetric dopamine biosensor based on boronic acid functional polythiophene modified electrodes","volume":"72","author":"Derviseevic","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.mseb.2012.04.012","article-title":"Impedimetric biosensor based on magnetic nanoparticles for electrochemical detection of dopamine","volume":"177","author":"Chandra","year":"2012","journal-title":"Mater. Sci. Eng. B"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1038\/srep05044","article-title":"Highly exposed {001} factes of titanium dioxide modified with reduced graphene oxide for dopamine sensing","volume":"4","author":"How","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S1452-3981(23)05065-4","article-title":"A sensitive amperometric sensor for the determination of dopamine at graphene and bismuth nanocomposite film modified electrode","volume":"10","author":"Mani","year":"2015","journal-title":"Int. J. Electrochem. Sci."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/17\/4880\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:04:21Z","timestamp":1760177061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/17\/4880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":48,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["s20174880"],"URL":"https:\/\/doi.org\/10.3390\/s20174880","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]}}}