{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:12:35Z","timestamp":1760710355965,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010016","name":"Nottingham Trent University","doi-asserted-by":"publisher","award":["00-11-22"],"award-info":[{"award-number":["00-11-22"]}],"id":[{"id":"10.13039\/100010016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>COVID-19 has shown a relatively low case fatality rate in young healthy individuals, with the majority of this group being asymptomatic or having mild symptoms. However, the severity of the disease among the elderly as well as in individuals with underlying health conditions has caused significant mortality rates worldwide. Understanding this variance amongst different sectors of society and modelling this will enable the different levels of risk to be determined to enable strategies to be applied to different groups. Long-established compartmental epidemiological models like SIR and SEIR do not account for the variability encountered in the severity of the SARS-CoV-2 disease across different population groups. The objective of this study is to investigate how a reduction in the exposure of vulnerable individuals to COVID-19 can minimise the number of deaths caused by the disease, using the UK as a case study. To overcome the limitation of long-established compartmental epidemiological models, it is proposed that a modified model, namely SEIR-v, through which the population is separated into two groups regarding their vulnerability to SARS-CoV-2 is applied. This enables the analysis of the spread of the epidemic when different contention measures are applied to different groups in society regarding their vulnerability to the disease. A Monte Carlo simulation (100,000 runs) along the proposed SEIR-v model is used to study the number of deaths which could be avoided as a function of the decrease in the exposure of vulnerable individuals to the disease. The results indicate a large number of deaths could be avoided by a slight realistic decrease in the exposure of vulnerable groups to the disease. The mean values across the simulations indicate 3681 and 7460 lives could be saved when such exposure is reduced by 10% and 20% respectively. From the encouraging results of the modelling a number of mechanisms are proposed to limit the exposure of vulnerable individuals to the disease. One option could be the provision of a wristband to vulnerable people and those without a smartphone and contact-tracing app, filling the gap created by systems relying on smartphone apps only. By combining very dense contact tracing data from smartphone apps and wristband signals with information about infection status and symptoms, vulnerable people can be protected and kept safer.<\/jats:p>","DOI":"10.3390\/s20174967","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T09:29:28Z","timestamp":1599038968000},"page":"4967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A COVID-19-Based Modified Epidemiological Model and Technological Approaches to Help Vulnerable Individuals Emerge from the Lockdown in the UK"],"prefix":"10.3390","volume":"20","author":[{"given":"Dario Ortega","family":"Anderez","sequence":"first","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-0661","authenticated-orcid":false,"given":"Eiman","family":"Kanjo","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK"}]},{"given":"Ganna","family":"Pogrebna","sequence":"additional","affiliation":[{"name":"Business School, The University of Sydney, Abercrombie Building H70, Darlington, NSW 2006, Australia"},{"name":"Alan Turing Institute, 96 Euston Road, London NW1 2DB, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-8244","authenticated-orcid":false,"given":"Omprakash","family":"Kaiwartya","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK"}]},{"given":"Shane D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Jill Dando Institute, University College London (UCL), 35 Tavistock Square, London WC1H 9EZ, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5168-4778","authenticated-orcid":false,"given":"John Alan","family":"Hunt","sequence":"additional","affiliation":[{"name":"Medical Technologies Innovation Facility, Nottingham Trent University, Nottingham NG11 8NS, UK"},{"name":"College of Biomedical Engineering, China Medical University, Taichung 40402, Taiwan"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","article-title":"Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology","volume":"Volume 39","author":"Channappanavar","year":"2017","journal-title":"Seminars in Immunopathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tim.2016.03.003","article-title":"Epidemiology, genetic recombination, and pathogenesis of coronaviruses","volume":"24","author":"Su","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_3","unstructured":"Worldometers.Info (2020, June 27). Coronavirus Update (Live): Worldometer. Available online: https:\/\/www.worldometers.info\/coronavirus."},{"key":"ref_4","unstructured":"Coates, S., Tanna, P., and Scott-Allen, E. (2019). Overview of the UK Population: August 2019, Office for National Statistics."},{"key":"ref_5","first-page":"700","article-title":"A contribution to the mathematical theory of epidemics","volume":"115","author":"Kermack","year":"1927","journal-title":"Proc. R. Soc. Lond. Ser. A Contain. Pap. Math. Phys. Character"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0022-5193(84)80150-2","article-title":"Seasonality and period-doubling bifurcations in an epidemic model","volume":"110","author":"Aron","year":"1984","journal-title":"J. Theor. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.abb6936","article-title":"Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing","volume":"368","author":"Ferretti","year":"2020","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1016\/S2468-2667(20)30061-X","article-title":"COVID-19 and the consequences of isolating the elderly","volume":"5","author":"Armitage","year":"2020","journal-title":"Lancet Public Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.21037\/jtd.2020.02.64","article-title":"Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions","volume":"12","author":"Yang","year":"2020","journal-title":"J. Thorac. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"L\u00f3pez, L., and Rodo, X. (2020). A modified SEIR model to predict the COVID-19 outbreak in Spain and Italy: Simulating control scenarios and multi-scale epidemics. Lancet.","DOI":"10.1101\/2020.03.27.20045005"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bongolan, V.P., Minoza, J.M.A., de Castro, R., and Sevilleja, J.E. (2020). Age-stratified Infection Probabilities Combined with Quarantine-Modified SEIR Model in the Needs Assessments for COVID-19. medRxiv.","DOI":"10.1101\/2020.04.08.20057851"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"R\u00f6st, G., Bartha, F.A., Bogya, N., Boldog, P., D\u00e9nes, A., Tam\u00e1s, F., Horv\u00e1th, K.J., Juh\u00e1sz, A., Nagy, C., and Tekeli, T. (2020). Early phase of the COVID-19 outbreak in Hungary and post-lockdown scenarios. medRxiv.","DOI":"10.1101\/2020.06.02.20119313"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1073\/pnas.2004064117","article-title":"Projecting hospital utilization during the COVID-19 outbreaks in the United States","volume":"117","author":"Moghadas","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Aleta, A., and Moreno, Y. (2020). Evaluation of the potential incidence of COVID-19 and effectiveness of contention measures in Spain: A data-driven approach. medRxiv.","DOI":"10.1101\/2020.03.01.20029801"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1440-1843.2006.00783.x","article-title":"Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance","volume":"11","author":"Mo","year":"2006","journal-title":"Respirology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.3201\/eid1310.070576","article-title":"Duration of antibody responses after severe acute respiratory syndrome","volume":"13","author":"Wu","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3201\/eid2206.160010","article-title":"Antibody response and disease severity in healthcare worker MERS survivors","volume":"22","author":"Alshukairi","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3201\/eid2210.160706","article-title":"Persistence of antibodies against Middle East respiratory syndrome coronavirus","volume":"22","author":"Payne","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_19","first-page":"77482","article-title":"Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand","volume":"10","author":"Ferguson","year":"2020","journal-title":"Imp. Coll. Lond."},{"key":"ref_20","unstructured":"Worldometers.Info (2020, June 02). United Kingdom Coronavirus: Worldometer. Available online: https:\/\/www.worldometers.info\/coronavirus\/country\/uk."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Linton, N.M., Kobayashi, T., Yang, Y., Hayashi, K., Akhmetzhanov, A.R., Jung, S.M., Yuan, B., Kinoshita, R., and Nishiura, H. (2020). Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: A statistical analysis of publicly available case data. J. Clin. Med., 9.","DOI":"10.1101\/2020.01.26.20018754"},{"key":"ref_22","unstructured":"Who.Int (2020, June 01). WHO|Contact Tracing. Available online: https:\/\/www.who.int\/csr\/disease\/ebola\/training\/contact-tracing\/en."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kanjo Eiman, K.C. (2012). Viral message passing framework for crowd and sensor applications. Networked Digital Technologies, Springer.","DOI":"10.1007\/978-3-642-30567-2_3"},{"key":"ref_24","first-page":"4","article-title":"Tools and architectural support for mobile phone based crowd control systems","volume":"4","author":"Eiman","year":"2012","journal-title":"Netw. Protoc. Algorithms"},{"key":"ref_25","unstructured":"Apple Newsroom (2020, May 12). Apple and Google Partner on COVID-19 Contact Tracing Technology. Available online: https:\/\/www.apple.com\/uk\/newsroom\/2020\/04\/apple-and-google-partner-on-covid-19-contact-tracing-technology."},{"key":"ref_26","unstructured":"Ofcom.Org.UK (2020, May 23). Adult\u2019s Media Use and Attitudes Report 2019. Available online: https:\/\/www.ofcom.org.uk\/__data\/assets\/pdf_file\/0021\/149124\/adults-media-use-and-attitudes-report.pdf."},{"key":"ref_27","unstructured":"Statista (2020, May 16). Internet Usage on Mobile Phone by Age GB 2010\u20132019. Available online: https:\/\/www.statista.com\/statistics\/320974\/internet-usage-on-mobile-phones-gb-age."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.gerinurse.2015.02.019","article-title":"Acceptability of wristband activity trackers among community dwelling older adults","volume":"36","author":"Hathaway","year":"2015","journal-title":"Geriatr. Nurs."},{"key":"ref_29","unstructured":"BBC News (2020, May 08). People-Tracking Wristbands Put to the Test. Available online: https:\/\/www.bbc.co.uk\/news\/technology-52409893."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ajic.2014.10.015","article-title":"Face touching: A frequent habit that has implications for hand hygiene","volume":"43","author":"Kwok","year":"2015","journal-title":"Am. J. Infect. Control."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Anderez, D.O., Lotfi, A., and Pourabdollah, A. (2019, January 6\u20138). Temporal convolution neural network for food and drink intake recognition. Proceedings of the 12th ACM International Conference on PErvasive Technologies Related to Assistive Environments, Rhodes, Greece.","DOI":"10.1145\/3316782.3322784"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"112888","DOI":"10.1016\/j.eswa.2019.112888","article-title":"Eating and drinking gesture spotting and recognition using a novel adaptive segmentation technique and a gesture discrepancy measure","volume":"140","author":"Lotfi","year":"2020","journal-title":"Expert Syst. Appl."},{"key":"ref_33","unstructured":"Who.Int (2020, May 02). Modes of Transmission of Virus Causing COVID-19: Implications for IPC Precaution Recommendations. Available online: https:\/\/www.who.int\/news-room\/commentaries\/detail\/modes-of-transmission-of-virus-causing-covid-19-implications-for-ipc-precaution-recommendations."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1445-5994.2004.00696.x","article-title":"Respiratory infections during air travel","volume":"35","author":"Leder","year":"2005","journal-title":"Intern. Med. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/jam.1989.2.285","article-title":"Inter comparison of experimental regional aerosol deposition data","volume":"2","author":"Stahlhofen","year":"1989","journal-title":"J. Aerosol Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1086\/429634","article-title":"Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units","volume":"191","author":"Booth","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMc2004973","article-title":"Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1","volume":"382","author":"Bushmaker","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12931-019-0970-9","article-title":"Exhaled particles and small airways","volume":"20","author":"Bake","year":"2019","journal-title":"Respir. Res."},{"key":"ref_39","unstructured":"Cascella, M., Rajnik, M., Cuomo, A., Dulebohn, S.C., and Di Napoli, R. (2020). Features, evaluation and treatment coronavirus (COVID-19). Statpearls [Internet], StatPearls Publishing."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41591-020-0843-2","article-title":"Respiratory virus shedding in exhaled breath and efficacy of face masks","volume":"26","author":"Leung","year":"2020","journal-title":"Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S2213-2600(20)30134-X","article-title":"Rational use of face masks in theCOVID-19 pandemic","volume":"8","author":"Feng","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.trf.2015.10.023","article-title":"Can novice drivers be motivated to use a smartphone based app that monitors their behavior?","volume":"42","author":"Musicant","year":"2016","journal-title":"Transp. Res. Part. F Traffic Psychol. Behav."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"b1415","DOI":"10.1136\/bmj.b1415","article-title":"Using financial incentives to achieve healthy behaviour","volume":"338","author":"Marteau","year":"2009","journal-title":"BMJ"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1257\/aer.89.1.103","article-title":"Doing it now or later","volume":"89","author":"Rabin","year":"1999","journal-title":"Am. Econ. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1037\/a0036208","article-title":"Structural brain correlates of delay of gratification in the elderly","volume":"128","author":"Drobetz","year":"2014","journal-title":"Behav. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11166-018-9289-z","article-title":"Present bias and health","volume":"57","author":"Wang","year":"2018","journal-title":"J. Risk Uncertain."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Albrecht, K., Volz, K.G., Sutter, M., and von Cramon, D.Y. (2013). What do I want and when do I want it: Brain correlates of decisions made for self and other. PLoS ONE, 8.","DOI":"10.1371\/annotation\/4a0ce951-49b2-4533-9cf0-773b5aeabb41"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/bdm.2031","article-title":"Present bias and everyday self-control failures: A day reconstruction study","volume":"30","author":"Delaney","year":"2017","journal-title":"J. Behav. Decis. Mak."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.paid.2016.02.016","article-title":"Individual differences in resting-state functional connectivity predict procrastination","volume":"95","author":"Wu","year":"2016","journal-title":"Personal. Individ. Differ."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/2229-3485.106389","article-title":"Vulnerable population and methods for their safeguard","volume":"4","author":"Shivayogi","year":"2013","journal-title":"Perspect. Clin. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/tmj.2016.0051","article-title":"Remote patient monitoring via non-invasivedigital technologies: A systematic review","volume":"23","author":"Vegesna","year":"2017","journal-title":"Telemed. E Health"},{"key":"ref_52","first-page":"118","article-title":"The use of technology by the elderly","volume":"4","author":"Roupa","year":"2010","journal-title":"Health Sci. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1745-6606.2006.00070.x","article-title":"The privacy paradox: Personal information disclosure intentions versus behaviors","volume":"41","author":"Norberg","year":"2007","journal-title":"J. Consum. Aff."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.dss.2010.11.017","article-title":"The personalization privacy paradox: An exploratory study of decision making process for location-aware marketing","volume":"51","author":"Xu","year":"2011","journal-title":"Decis. Support. Syst."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.2307\/4093335","article-title":"Property, privacy, and personal data","volume":"117","author":"Schwartz","year":"2003","journal-title":"Harv. L. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.18178\/ijtef.2016.7.4.510","article-title":"The willingness to trade privacy in the context of WTA and WTP","volume":"7","author":"Bizon","year":"2016","journal-title":"Int. J. Trade Econ. Financ."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1145\/219663.219683","article-title":"Values, personal information privacy, and regulatory approaches","volume":"38","author":"Milberg","year":"1995","journal-title":"Commun. ACM"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10916-017-0739-y","article-title":"TraPy-MAC: Traffic priority aware medium access control protocol for wireless body area network","volume":"41","author":"Ullah","year":"2017","journal-title":"J. Med. Syst."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1515\/jaiscr-2017-0003","article-title":"A new mechanism for data visualization with TSK-type preprocessed collaborative fuzzy rule based system","volume":"7","author":"Prasad","year":"2017","journal-title":"J. Artif. Intell. Soft Comput. Res."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/17\/4967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:05:52Z","timestamp":1760177152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/17\/4967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":59,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["s20174967"],"URL":"https:\/\/doi.org\/10.3390\/s20174967","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2020,9,2]]}}}