{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:23:23Z","timestamp":1767849803951,"version":"3.49.0"},"reference-count":34,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006690","name":"Politecnico di Milano","doi-asserted-by":"publisher","award":["Tid mekii"],"award-info":[{"award-number":["Tid mekii"]}],"id":[{"id":"10.13039\/501100006690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006690","name":"Politecnico di Milano","doi-asserted-by":"publisher","award":["Switch to product 2018"],"award-info":[{"award-number":["Switch to product 2018"]}],"id":[{"id":"10.13039\/501100006690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The development of innovative diagnostic tests is fundamental in the route towards malaria eradication. Here, we discuss the sorting capabilities of an innovative test for malaria which allows the quantitative and rapid detection of all malaria species. The physical concept of the test exploits the paramagnetic property of infected erythrocytes and hemozoin crystals, the magnetic fingerprints of malaria common to all species, which allows them to undergo a selective magnetophoretic separation driven by a magnetic field gradient in competition with gravity. Upon separation, corpuscles concentrate at the surface of a silicon microchip where interdigitated electrodes are placed in close proximity to magnetic concentrators. The impedance variation proportional to the amount of attracted particles is then measured. The capability of our test to perform the selective detection of infected erythrocytes and hemozoin crystals has been tested by means of capture experiments on treated bovine red blood cells, mimicking the behavior of malaria-infected ones, and suspensions of synthetic hemozoin crystals. Different configuration angles of the chip with respect to gravity force and different thicknesses of the microfluidic chamber containing the blood sample have been investigated experimentally and by multiphysics simulations. In the paper, we describe the optimum conditions leading to maximum sensitivity and specificity of the test.<\/jats:p>","DOI":"10.3390\/s20174972","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T09:29:28Z","timestamp":1599038968000},"page":"4972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["On-Chip Selective Capture and Detection of Magnetic Fingerprints of Malaria"],"prefix":"10.3390","volume":"20","author":[{"given":"Francesca","family":"Milesi","sequence":"first","affiliation":[{"name":"Department of Physics, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milano, Italy"}]},{"given":"Marco","family":"Giacometti","sequence":"additional","affiliation":[{"name":"Department of Electronics Information and Bioengineering, Politecnico di Milano, Via Giuseppe Ponzio, 34, 20133 Milano, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-8164","authenticated-orcid":false,"given":"Lorenzo Pietro","family":"Coppadoro","sequence":"additional","affiliation":[{"name":"Department of Electronics Information and Bioengineering, Politecnico di Milano, Via Giuseppe Ponzio, 34, 20133 Milano, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2854-8444","authenticated-orcid":false,"given":"Giorgio","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Electronics Information and Bioengineering, Politecnico di Milano, Via Giuseppe Ponzio, 34, 20133 Milano, Italy"}]},{"given":"Gianfranco Beniamino","family":"Fiore","sequence":"additional","affiliation":[{"name":"Department of Electronics Information and Bioengineering, Politecnico di Milano, Via Giuseppe Ponzio, 34, 20133 Milano, Italy"}]},{"given":"Riccardo","family":"Bertacco","sequence":"additional","affiliation":[{"name":"Department of Physics, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milano, Italy"},{"name":"IFN-CNR, c\/o Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133 Milano, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018). 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