{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:25:27Z","timestamp":1776954327439,"version":"3.51.4"},"reference-count":35,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>An advanced Surface-Enhanced Raman Scattering (SERS) Nanosensor Array, dedicated to serve in the future as a pH imager for the real-time detection of chemical reaction, is presented. The full flow of elementary steps\u2014architecture, design, simulations, fabrication, and preliminary experimental results of structural characterization (Focused Ion Beam (FIB), TEM and SEM)\u2014show an advanced SERS pixel array that is capable of providing spatially resolved measurements of chemical pH in a fluid target that became more than desirable in this period. Ultimately, the goal will be to provide real-time monitoring of a chemical reaction. The pixels consist of a nanostructured substrate composed of an array of projections or cavities. The shape of the nanostructures and the thickness of the metallic (Ag or Au) layer can be tuned to give maximal enhancement at the desired wavelength. The number and arrangement of nanostructures is optimized to obtain maximal responsivity.<\/jats:p>","DOI":"10.3390\/s20185123","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T09:03:48Z","timestamp":1599555828000},"page":"5123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Design of Surface Enhanced Raman Scattering (SERS) Nanosensor Array"],"prefix":"10.3390","volume":"20","author":[{"given":"Yaakov","family":"Mandelbaum","sequence":"first","affiliation":[{"name":"Advanced Laboratory of Electro-Optics (ALEO), Department of Applied Physics\/Electro-Optics Engineering, Lev Academic Center, 9116001 Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-6073","authenticated-orcid":false,"given":"Raz","family":"Mottes","sequence":"additional","affiliation":[{"name":"Advanced Laboratory of Electro-Optics (ALEO), Department of Applied Physics\/Electro-Optics Engineering, Lev Academic Center, 9116001 Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-3421","authenticated-orcid":false,"given":"Zeev","family":"Zalevsky","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Bar-Ilan University, 5290002 Ramat Gan, Israel"},{"name":"The Nanotechnology Center, Bar-Ilan University, 5290002 Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-6165","authenticated-orcid":false,"given":"David","family":"Zitoun","sequence":"additional","affiliation":[{"name":"The Nanotechnology Center, Bar-Ilan University, 5290002 Ramat Gan, Israel"},{"name":"Faculty of Exact Sciences, Department of Chemistry, Bar-Ilan University, 5290002 Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0518-9028","authenticated-orcid":false,"given":"Avi","family":"Karsenty","sequence":"additional","affiliation":[{"name":"Advanced Laboratory of Electro-Optics (ALEO), Department of Applied Physics\/Electro-Optics Engineering, Lev Academic Center, 9116001 Jerusalem, Israel"},{"name":"Nanotechnology Center for Education and Research, Lev Academic Center, 9116001 Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"ref_1","unstructured":"Etchegoin, P., and LeRu, E. 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