{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:58:55Z","timestamp":1780469935938,"version":"3.54.1"},"reference-count":85,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Colorimetric analysis has become of great importance in recent years to improve the operationalization of plasmonic-based biosensors. The unique properties of nanomaterials have enabled the development of a variety of plasmonics applications on the basis of the colorimetric sensing provided by metal nanoparticles. In particular, the extinction of localized surface plasmon resonance (LSPR) in the visible range has permitted the exploitation of LSPR colorimetric-based biosensors as powerful tools for clinical diagnostics and drug monitoring. This review summarizes recent progress in the biochemical monitoring of clinical biomarkers by ultrasensitive plasmonic colorimetric strategies according to the distance- or the morphology\/size-dependent sensing modes. The potential of colorimetric nanosensors as point of care devices from the perspective of naked-eye detection is comprehensively discussed for a broad range of analytes including pharmaceuticals, proteins, carbohydrates, nucleic acids, bacteria, and viruses such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The practical suitability of plasmonic-based colorimetric assays for the rapid visual readout in biological samples, considering current challenges and future perspectives, is also reviewed.<\/jats:p>","DOI":"10.3390\/s20216214","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T21:34:47Z","timestamp":1604093687000},"page":"6214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Clinical Applications of Visual Plasmonic Colorimetric Sensing"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-8107","authenticated-orcid":false,"given":"Elba","family":"Mauriz","sequence":"first","affiliation":[{"name":"Department of Nursing and Physiotherapy, Campus de Vegazana, Universidad de Le\u00f3n, s\/n, 24071 Le\u00f3n, Spain"},{"name":"Institute of Food Science and Technology (ICTAL), La Serna 58, 24007 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2471\/BLT.16.187468","article-title":"A guide to aid the selection of diagnostic tests","volume":"95","author":"Kosack","year":"2017","journal-title":"Bull. World Health Organ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bios.2015.11.097","article-title":"Label-free SPR detection of gluten peptides in urine for non-invasive celiac disease follow-up","volume":"79","author":"Soler","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1700197","DOI":"10.1002\/smtd.201700197","article-title":"Construction of Plasmonic Nano-Biosensor-Based Devices for Point-of-Care Testing","volume":"1","author":"Wang","year":"2017","journal-title":"Small Methods"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rohr, U.-P., Binder, C., Dieterle, T., Giusti, F., Messina, C.G.M., Toerien, E., Moch, H., and Sch\u00e4fer, H.H. (2016). The Value of In Vitro Diagnostic Testing in Medical Practice: A Status Report. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149856"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1007\/s12274-018-2094-9","article-title":"Plasmonic molecular assays: Recent advances and applications for mobile health","volume":"11","author":"Yu","year":"2018","journal-title":"Nano Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"112349","DOI":"10.1016\/j.bios.2020.112349","article-title":"Diagnostic methods and potential portable biosensors for coronavirus disease 2019","volume":"165","author":"Cui","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cca.2019.03.008","article-title":"Point of care testing for infectious diseases","volume":"493","author":"Chen","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107440","DOI":"10.1016\/j.biotechadv.2019.107440","article-title":"Plasmonic-based platforms for diagnosis of infectious diseases at the point-of-care","volume":"37","author":"Li","year":"2019","journal-title":"Biotechnol. Adv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.3390\/s20071951","article-title":"Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics","volume":"20","year":"2020","journal-title":"Sensors"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1039\/C9AN02149C","article-title":"Are plasmonic optical biosensors ready for use in point-of-need applications?","volume":"145","author":"Liu","year":"2020","journal-title":"Analyst"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1039\/C9AN02485A","article-title":"Multiplexed detection of biomarkers in lateral-flow immunoassays","volume":"145","author":"Huang","year":"2020","journal-title":"Analyst"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1177\/1932296820906184","article-title":"Meeting the New FDA Standard for Accuracy of Self-Monitoring Blood Glucose Test Systems Intended for Home Use by Lay Users","volume":"14","author":"Katz","year":"2020","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1021\/cr2001178","article-title":"Gold Nanoparticles in Chemical and Biological Sensing","volume":"112","author":"Saha","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1021\/acssensors.7b00282","article-title":"Plasmon-Based Colorimetric Nanosensors for Ultrasensitive Molecular Diagnostics","volume":"2","author":"Tang","year":"2017","journal-title":"ACS Sens."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bios.2018.05.015","article-title":"Plasmonic colorimetric sensors based on etching and growth of noble metal nanoparticles: Strategies and applications","volume":"114","author":"Zhang","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113003","DOI":"10.1016\/j.ccr.2019.06.020","article-title":"Noble metal nanoparticles growth-based colorimetric strategies: From monocolorimetric to multicolorimetric sensors","volume":"398","author":"Wang","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Liu, G., Lu, M., Huang, X., Li, T., and Xu, D. (2018). Application of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety Screening. Sensors, 18.","DOI":"10.3390\/s18124166"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.trac.2018.05.004","article-title":"Recent progress on surface chemistry of plasmonic metal nanoparticles for colorimetric assay of drugs in pharmaceutical and biological samples","volume":"105","author":"Kailasa","year":"2018","journal-title":"Trac Trends Anal. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1002\/adma.201101853","article-title":"Colorimetric Biosensing Using Smart Materials","volume":"23","author":"Song","year":"2011","journal-title":"Adv. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1039\/b712179m","article-title":"The use of gold nanoparticles in diagnostics and detection","volume":"37","author":"Wilson","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1002\/cbic.200800282","article-title":"Design of Gold Nanoparticle-Based Colorimetric Biosensing Assays","volume":"9","author":"Zhao","year":"2008","journal-title":"ChemBioChem"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1021\/jp037056a","article-title":"The Surface Chemistry of Au Colloids and Their Interactions with Functional Amino Acids","volume":"108","author":"Zhong","year":"2004","journal-title":"J. Phys. Chem. B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1021\/nn5008786","article-title":"A Highly Sensitive Plasmonic DNA Assay Based on Triangular Silver Nanoprism Etching","volume":"8","author":"Yang","year":"2014","journal-title":"ACS Nano"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1021\/acs.analchem.8b00597","article-title":"Nanoplasmonic Sensing from the Human Vision Perspective","volume":"90","author":"Chen","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1021\/acs.analchem.5b04621","article-title":"Gold Nanorods as Colorful Chromogenic Substrates for Semiquantitative Detection of Nucleic Acids, Proteins, and Small Molecules with the Naked Eye","volume":"88","author":"Ma","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/cr068107d","article-title":"Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species","volume":"108","author":"Homola","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1039\/c3cp50281c","article-title":"Modern surface plasmon resonance for bioanalytics and biophysics","volume":"15","author":"Couture","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1039\/D0AN00316F","article-title":"Portable and field-deployed surface plasmon resonance and plasmonic sensors","volume":"145","author":"Masson","year":"2020","journal-title":"Analyst"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1039\/C4AN01079E","article-title":"Plasmon-enhanced optical sensors: A review","volume":"140","author":"Li","year":"2015","journal-title":"Analyst"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10575","DOI":"10.1021\/acs.chemrev.5b00100","article-title":"Gold Nanoparticles for In Vitro Diagnostics","volume":"115","author":"Zhou","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1039\/C4EN00211C","article-title":"Plasmonic colorimetric and SERS sensors for environmental analysis","volume":"2","author":"Wei","year":"2015","journal-title":"Environ. Sci. Nano"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1021\/acssensors.9b00438","article-title":"Noble Metal Nanoparticle-Based Multicolor Immunoassays: An Approach toward Visual Quantification of the Analytes with the Naked Eye","volume":"4","author":"Ma","year":"2019","journal-title":"ACS Sens."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ccr.2019.02.019","article-title":"In situ formed nanomaterials for colorimetric and fluorescent sensing","volume":"387","author":"Guo","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1021\/cr0680282","article-title":"Interparticle Coupling Effect on the Surface Plasmon Resonance of Gold Nanoparticles: From Theory to Applications","volume":"107","author":"Ghosh","year":"2007","journal-title":"Chem. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"115754","DOI":"10.1016\/j.trac.2019.115754","article-title":"Colorimetric sensor array based on gold nanoparticles: Design principles and recent advances","volume":"122","author":"Sun","year":"2020","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1021\/acssensors.9b00063","article-title":"Ultrafast and Ultrasensitive Naked-Eye Detection of Urease-Positive Bacteria with Plasmonic Nanosensors","volume":"4","author":"Santopolo","year":"2019","journal-title":"ACS Sens."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.msec.2017.05.018","article-title":"Colorimetric sensors for rapid detection of various analytes","volume":"78","author":"Piriya","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.apsusc.2019.03.175","article-title":"Shell surface sulfidation mediated the plasmonic response of Au@Ag NPs for colorimetric sensing of sulfide ions and sulfur","volume":"481","author":"Liu","year":"2019","journal-title":"Appl. Surf. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1080\/00032719.2020.1743715","article-title":"Colorimetric and Surface Enhanced Raman Scattering (SERS) Detection of Metal Ions in Aqueous Medium Using Sensitive, Robust and Novel Pectin Functionalized Silver Nanoparticles","volume":"53","author":"Sharma","year":"2020","journal-title":"Anal. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1002\/anie.200700269","article-title":"Colorimetric Detection of Mercuric Ion (Hg2+) in Aqueous Media using DNA-Functionalized Gold Nanoparticles","volume":"46","author":"Lee","year":"2007","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1002\/smll.201500903","article-title":"A Dispersion-Dominated Chromogenic Strategy for Colorimetric Sensing of Glutathione at the Nanomolar Level Using Gold Nanoparticles","volume":"11","author":"Xianyu","year":"2015","journal-title":"Small"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aca.2018.11.015","article-title":"Silver nanoparticles-based plasmonic assay for the determination of sugar content in food matrices","volume":"1051","author":"Scroccarello","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1002\/anie.201001057","article-title":"Colorimetric Detection of Glucose in Rat Brain Using Gold Nanoparticles","volume":"49","author":"Jiang","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1039\/C9TC00757A","article-title":"Gold nanorod etching-based multicolorimetric sensors: Strategies and applications","volume":"7","author":"Rao","year":"2019","journal-title":"J. Mater. Chem. C"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Liu, L., Hao, Y., Deng, D., and Xia, N. (2019). Nanomaterials-Based Colorimetric Immunoassays. Nanomaterials, 9.","DOI":"10.3390\/nano9030316"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1039\/C4AY01993H","article-title":"Highly sensitive \u201csignal on\u201d plasmonic ELISA for small molecules by the naked eye","volume":"6","author":"Peng","year":"2014","journal-title":"Anal. Methods"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11220","DOI":"10.1021\/acs.chemrev.6b00196","article-title":"Self-Assembly of Colloidal Nanocrystals: From Intricate Structures to Functional Materials","volume":"116","author":"Boles","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1021\/cr400081d","article-title":"Advances in Colloidal Assembly: The Design of Structure and Hierarchy in Two and Three Dimensions","volume":"115","author":"Vogel","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.trac.2018.07.003","article-title":"Nanomaterials for the sensing of narcotics: Challenges and opportunities","volume":"106","author":"Kumar","year":"2018","journal-title":"Trac Trends Anal. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Garz\u00f3n, V., Pinacho, D.G., Bustos, R.-H., Garz\u00f3n, G., and Bustamante, S. (2019). Optical Biosensors for Therapeutic Drug Monitoring. Biosensors, 9.","DOI":"10.3390\/bios9040132"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/jalm\/jfaa067","article-title":"Point-of-Care Therapeutic Drug Monitoring for Precision Dosing of Immunosuppressive Drugs","volume":"5","author":"Taddeo","year":"2020","journal-title":"J. Appl. Lab. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"137428","DOI":"10.1016\/j.tsf.2019.137428","article-title":"Solid-phase colorimetric apta-biosensor for thrombin detection","volume":"686","author":"Lee","year":"2019","journal-title":"Thin Solid Film."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aca.2020.05.016","article-title":"Controlled reversible assembly of gold nanoparticles as a new colorimetric and sensitive detection of glucose-6-phosphate dehydrogenase deficiency","volume":"1122","author":"Boonyuen","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"095501","DOI":"10.1088\/1361-6528\/ab55b7","article-title":"A colorimetric detection of microRNA-148a in gastric cancer by gold nanoparticle\u2013RNA conjugates","volume":"31","author":"Cai","year":"2020","journal-title":"Nanotechnology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11916","DOI":"10.1002\/anie.201703807","article-title":"Aptamer\/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins","volume":"56","author":"Jiang","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"104601","DOI":"10.1016\/j.microc.2020.104601","article-title":"Sodium gluconate capped silver nanoparticles as a highly sensitive and selective colorimetric probe for the naked eye sensing of creatinine in human serum and urine","volume":"154","author":"Sadeghi","year":"2020","journal-title":"Microchem. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1039\/D0AN00656D","article-title":"DNA-Programmed plasmonic ELISA for the ultrasensitive detection of protein biomarkers","volume":"145","author":"Cheng","year":"2020","journal-title":"Analyst"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"12169","DOI":"10.1039\/D0NJ02152K","article-title":"Smart phone assisted, rapid, simplistic, straightforward and sensitive biosensing of cysteine over other essential amino acids by \u03b2-cyclodextrin functionalized gold nanoparticles as a colorimetric probe","volume":"44","author":"Rajamanikandan","year":"2020","journal-title":"New J. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.jksus.2017.12.001","article-title":"Rapid naked eye detection of arginine by pomegranate peel extract stabilized gold nanoparticles","volume":"31","author":"Kaviya","year":"2019","journal-title":"J. King Saud Univ. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aca.2018.03.022","article-title":"Development of extremely stable dual functionalized gold nanoparticles for effective colorimetric detection of clenbuterol and ractopamine in human urine samples","volume":"1023","author":"Simon","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1021\/acsnano.0c03822","article-title":"Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles","volume":"14","author":"Moitra","year":"2020","journal-title":"ACS Nano"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"15604","DOI":"10.1039\/D0NR03517C","article-title":"An amplification-free colorimetric test for sensitive DNA detection based on the capturing of gold nanoparticle clusters","volume":"12","author":"Tatulli","year":"2020","journal-title":"Nanoscale"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aca.2017.01.023","article-title":"Sensitive detection of respiratory syncytial virus based on a dual signal amplified plasmonic enzyme-linked immunosorbent assay","volume":"962","author":"Zhan","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s42452-020-2425-9","article-title":"Colorimetric detection of fluoxetine using citrate-capped silver nanoparticles","volume":"2","author":"Laghari","year":"2020","journal-title":"Sn Appl. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1007\/s00216-019-02105-5","article-title":"Visual and spectrophotometric detection of metformin based on the host-guest molecular recognition of cucurbit[6]uril-modified silver nanoparticles","volume":"411","author":"Song","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.saa.2016.07.011","article-title":"Surface plasmon resonance based selective and sensitive colorimetric determination of azithromycin using unmodified silver nanoparticles in pharmaceuticals and human plasma","volume":"170","author":"Chavada","year":"2017","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/bkcs.11095","article-title":"In Situ Growth of Plasmonic Gold Nanoparticles for the Direct and Sensitive Colorimetric Assay of Glucose","volume":"38","author":"Weng","year":"2017","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"(2019). Phiri; Mulder; Vorster Plasmonic Detection of Glucose in Serum Based on Biocatalytic Shape-Altering of Gold Nanostars. Biosensors, 9.","DOI":"10.3390\/bios9030083"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"37879","DOI":"10.1038\/srep37879","article-title":"Multicolor Colormetric Biosensor for the Determination of Glucose based on the Etching of Gold Nanorods","volume":"6","author":"Lin","year":"2016","journal-title":"Sci Rep"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.bios.2016.09.090","article-title":"Highly sensitive on-site detection of glucose in human urine with naked eye based on enzymatic-like reaction mediated etching of gold nanorods","volume":"89","author":"Zhang","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.aca.2019.04.053","article-title":"A morphology-based ultrasensitive multicolor colorimetric assay for detection of blood glucose by enzymatic etching of plasmonic gold nanobipyramids","volume":"1071","author":"Xu","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"35001","DOI":"10.1039\/C6RA04976A","article-title":"Sensitive colorimetric detection of glucose and cholesterol by using Au@Ag core\u2013shell nanoparticles","volume":"6","author":"Zhang","year":"2016","journal-title":"RSC Adv."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1039\/D0CC01086C","article-title":"A dual-round signal amplification strategy for colorimetric\/photoacoustic\/fluorescence triple read-out detection of prostate specific antigen","volume":"56","author":"Jiang","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1021\/acs.nanolett.7b02385","article-title":"Platinum-Decorated Gold Nanoparticles with Dual Functionalities for Ultrasensitive Colorimetric in Vitro Diagnostics","volume":"17","author":"Gao","year":"2017","journal-title":"Nano Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bios.2016.08.021","article-title":"A universal multicolor immunosensor for semiquantitative visual detection of biomarkers with the naked eyes","volume":"87","author":"Ma","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"128215","DOI":"10.1016\/j.snb.2020.128215","article-title":"A catalytic\u2014regulated gold nanorods etching process as a receptor with multiple readouts for protein detection","volume":"318","author":"Wang","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1021\/acs.analchem.6b02966","article-title":"Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells","volume":"89","author":"Huang","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"112325","DOI":"10.1016\/j.bios.2020.112325","article-title":"A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level","volume":"165","author":"Pang","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.3168\/jds.2018-15580","article-title":"Urease-induced metallization of gold nanorods for the sensitive detection of Salmonella enterica Choleraesuis through colorimetric ELISA","volume":"102","author":"Gao","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"111488","DOI":"10.1016\/j.bios.2019.111488","article-title":"Plasmonic nanoplatform for point-of-care testing trace HCV core protein","volume":"147","author":"Li","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.1021\/acs.analchem.8b00756","article-title":"Highly Selective, Naked-Eye, and Trace Discrimination between Perfect-Match and Mismatch Sequences Using a Plasmonic Nanoplatform","volume":"90","author":"Yin","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"46462","DOI":"10.1021\/acsami.9b14980","article-title":"Core\u2013Shell Gold\/Silver Nanoparticles for Localized Surface Plasmon Resonance-Based Naked-Eye Toxin Biosensing","volume":"11","author":"Loiseau","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Mohd Bakhori, N., Yusof, N., Abdullah, J., Wasoh, H., Md Noor, S., Ahmad Raston, N., and Mohammad, F. (2018). Immuno Nanosensor for the Ultrasensitive Naked Eye Detection of Tuberculosis. Sensors, 18.","DOI":"10.3390\/s18061932"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.aca.2020.04.060","article-title":"Enhanced LSPR performance of graphene nanoribbons-silver nanoparticles hybrid as a colorimetric sensor for sequential detection of dopamine and glutathione","volume":"1120","author":"Rostami","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bios.2016.06.040","article-title":"Multidimensional colorimetric sensor array for discrimination of proteins","volume":"86","author":"Mao","year":"2016","journal-title":"Biosens. Bioelectron."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/21\/6214\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:27:22Z","timestamp":1760178442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/20\/21\/6214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":85,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["s20216214"],"URL":"https:\/\/doi.org\/10.3390\/s20216214","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]}}}