{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:10:09Z","timestamp":1782331809714,"version":"3.54.5"},"reference-count":45,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO3) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP\/anti-CRP interaction. The CRP\/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 \u03bcg\/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 \u03bcg\/mL to 1 mg\/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/s20226640","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T02:09:07Z","timestamp":1605838147000},"page":"6640","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Surface Acoustic Wave Sensor for C-Reactive Protein Detection"],"prefix":"10.3390","volume":"20","author":[{"given":"Ming-Jer","family":"Jeng","sequence":"first","affiliation":[{"name":"Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 244, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chang","family":"Li","sequence":"additional","affiliation":[{"name":"Green Technology Research Center, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Lung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 244, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-9938","authenticated-orcid":false,"given":"Shiang-Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 244, Taiwan"},{"name":"Department of Public Health, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2174-2022","authenticated-orcid":false,"given":"Liann-Be","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 244, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2069-7533","authenticated-orcid":false,"given":"Chao-Sung","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa040967","article-title":"Inflammatory markers and the risk of coronary heart disease in men and women","volume":"351","author":"Pai","year":"2004","journal-title":"N. 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