{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:45:35Z","timestamp":1785887135970,"version":"3.56.0"},"reference-count":15,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007120","name":"King Mongkut's Institute of Technology Ladkrabang","doi-asserted-by":"publisher","award":["KREF026201"],"award-info":[{"award-number":["KREF026201"]}],"id":[{"id":"10.13039\/501100007120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This paper presents a 0.5 V fifth-order Butterworth low-pass filter based on multiple-input operational transconductance amplifiers (OTA). The filter is designed for electrocardiogram (ECG) acquisition systems and operates in the subthreshold region with nano-watt power consumption. The used multiple-input technique simplifies the overall structure of the OTA and reduces the number of active elements needed to realize the filter. The filter was designed and simulated in the Cadence environment using a 0.18 \u00b5m Complementary Metal Oxide Semiconductor (CMOS) process from Taiwan Semiconductor Manufacturing Company (TSMC). Simulation results show that the filter has a bandwidth of 250 Hz, a power consumption of 34.65 nW, a dynamic range of 63.24 dB, attaining a figure-of-merit of 0.0191 pJ. The corner (process, voltage, temperature: PVT) and Monte Carlo (MC) analyses are included to prove the robustness of the filter.<\/jats:p>","DOI":"10.3390\/s20247343","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T09:41:41Z","timestamp":1608543701000},"page":"7343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["0.5 V Fifth-Order Butterworth Low-Pass Filter Using Multiple-Input OTA for ECG Applications"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-9081","authenticated-orcid":false,"given":"Montree","family":"Kumngern","sequence":"first","affiliation":[{"name":"Department of Telecommunications Engineering, Faculty of Engineering, King Mongkut\u2019s Institute of Technology Ladkrabang, Bangkok 10520, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattharinee","family":"Aupithak","sequence":"additional","affiliation":[{"name":"Department of Telecommunications Engineering, Faculty of Engineering, King Mongkut\u2019s Institute of Technology Ladkrabang, Bangkok 10520, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9864-9830","authenticated-orcid":false,"given":"Fabian","family":"Khateb","sequence":"additional","affiliation":[{"name":"Department of Microelectronics, Brno University of Technology, Technicka 3058\/10, 612 00 Brno, Czech Republic"},{"name":"Faculty of Biomedical Engineering, Czech Technical University in Prague, n\u00e1m. S\u00edtn\u00e1 3105, 272 01 Kladno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-9292","authenticated-orcid":false,"given":"Tomasz","family":"Kulej","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Czestochowa University of Technology, 42-201 Czestochowa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"ref_1","unstructured":"Webster, J.G. (2010). Medical Instrumentation: Application and Design, John Wiley & Sons. [4th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1109\/TBCAS.2013.2238233","article-title":"15-nW biopotential LPFs in 0.35-\u03bcm CMOS using subthreshold-source-follower biquads with and without gain compensation","volume":"7","author":"Zhang","year":"2013","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1109\/TVLSI.2018.2863706","article-title":"A 0.9-nW, 101-Hz, and 46.3-\u00b5Vrms IRN low-pass filter fir ECG acquisition using FVF biquad","volume":"26","author":"Sawigun","year":"2018","journal-title":"IEEE Trans. Very Large Scale Integr. Syst."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1109\/TCSI.2018.2808361","article-title":"A subthreshold buffer-based biquadratic cell and its application to biopotential filter design","volume":"65","author":"Sawigun","year":"2018","journal-title":"IEEE Trans. Circuits Syst. I Regul. Pap."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1109\/TCSI.2018.2885954","article-title":"A nanopower biopotential lowpass filter using subthreshold current-reuse biquads with bulk effect self-neutralization","volume":"66","author":"Sawigun","year":"2019","journal-title":"IEEE Trans. Circuits Syst. I Regul. Pap."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sreenivasulu, P., Hanumantha Rao, G., Rekha, S., and Bhat, M.S. (2019). A 0.3 V, 56 dB DR, 100 Hz fourth order low-pass filter for ECG acquisition. Microelectron. J., 94.","DOI":"10.1016\/j.mejo.2019.104652"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1109\/TBCAS.2008.2007423","article-title":"Systematic design and modelling of a OTA-C filter for portable ECG detection","volume":"3","author":"Lee","year":"2009","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_8","first-page":"421","article-title":"A fifth-order Butterworth OTA-C LPF with multiple-output differential-input OTA for ECG applications","volume":"65","author":"Sun","year":"2018","journal-title":"IEEE Trans. Biomed. Circuits Syst. II Express Briefs"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1109\/TBCAS.2018.2882521","article-title":"Low-voltage OTA\u2013C filter with an area and power-efficient OTA for biosignal sensor applications","volume":"13","author":"Lee","year":"2019","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pinto, P.M., Ferreira, L.H.C., Colletta, G.D., and Braga, R.A.S. (2019). A 0.25-V fifth-order Butterworth low-pass filter based on fully differential difference transconductance amplifier architecture. Microelectron. J., 92.","DOI":"10.1016\/j.mejo.2019.104606"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1007\/s00034-018-0999-x","article-title":"Multiple-input bulk-driven MOS transistor for low-voltage low-frequency applications","volume":"38","author":"Khateb","year":"2019","journal-title":"Circuits Syst. Signal Process."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.aeue.2018.12.023","article-title":"Multiple-input bulk-driven quasi-floating-gate MOS transistor for low-voltage low-power integrated circuits","volume":"100","author":"Khateb","year":"2019","journal-title":"AEU Int. J. Electron. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.aeue.2019.06.003","article-title":"Comparative performance study of multiple-input Bulk-driven and multiple-input Bulk-driven Quasi-floating-gate DDCCs","volume":"108","author":"Khateb","year":"2019","journal-title":"Int. J. Electron. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kumngern, M., Kulej, T., Stopjakova, V., and Khateb, F. (2019). 0.5V sixth-order Chebyshev band-pass filter based on multiple-input bulk-driven OTA. AEU Int. J. Electron. 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