{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:23:58Z","timestamp":1776183838827,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute for Information &amp; Communications Technology Planning &amp; Evaluation","award":["IITP-2020-0-01517"],"award-info":[{"award-number":["IITP-2020-0-01517"]}]},{"name":"Georgia Tech Institute for Electronics and Nanotechnology","award":["Center Grant"],"award-info":[{"award-number":["Center Grant"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ECCS-2025462"],"award-info":[{"award-number":["ECCS-2025462"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Sleep is an essential element to human life, restoring the brain and body from accumulated fatigue from daily activities. Quantitative monitoring of daily sleep quality can provide critical feedback to evaluate human health and life patterns. However, the existing sleep assessment system using polysomnography is not available for a home sleep evaluation, while it requires multiple sensors, tabletop electronics, and sleep specialists. More importantly, the mandatory sleep in a designated lab facility disrupts a subject\u2019s regular sleep pattern, which does not capture one\u2019s everyday sleep behaviors. Recent studies report that galvanic skin response (GSR) measured on the skin can be one indicator to evaluate the sleep quality daily at home. However, the available GSR detection devices require rigid sensors wrapped on fingers along with separate electronic components for data acquisition, which can interrupt the normal sleep conditions. Here, we report a new class of materials, sensors, electronics, and packaging technologies to develop a wireless, soft electronic system that can measure GSR on the wrist. The single device platform that avoids wires, rigid sensors, and straps offers the maximum comfort to wear on the skin and minimize disruption of a subject\u2019s sleep. A nanomaterial GSR sensor, printed on a soft elastomeric membrane, can have intimate contact with the skin to reduce motion artifact during sleep. A multi-layered flexible circuit mounted on top of the sensor provides a wireless, continuous, real-time recording of GSR to classify sleep stages, validated by the direct comparison with the standard method that measures other physiological signals. Collectively, the soft bioelectronic system shows great potential to be working as a portable, at-home sensor system for assessing sleep quality before a hospital visit.<\/jats:p>","DOI":"10.3390\/s21020354","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T01:51:58Z","timestamp":1609984318000},"page":"354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Soft Wireless Bioelectronics and Differential Electrodermal Activity for Home Sleep Monitoring"],"prefix":"10.3390","volume":"21","author":[{"given":"Hojoong","family":"Kim","sequence":"first","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA"}]},{"given":"Shinjae","family":"Kwon","sequence":"additional","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA"}]},{"given":"Young-Tae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department for Metal Powder, Korea Institute of Materials Science, Changwon 51508, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-3882","authenticated-orcid":false,"given":"Woon-Hong","family":"Yeo","sequence":"additional","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA"},{"name":"Wallace H. Coulter Department of Biomedical Engineering and Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA"},{"name":"Center for Human-Centric Interfaces and Engineering, Neural Engineering Center, Institute for Materials, and Institute for Robotics and Intelligent Machines, Georgia Institute of Technology, Atlanta, GA 30332, USA"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/nature04285","article-title":"Clues to the functions of mammalian sleep","volume":"437","author":"Siegel","year":"2005","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsmc.2016.10.012","article-title":"Sleep, health, and society","volume":"12","author":"Grandner","year":"2017","journal-title":"Sleep Med. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainresbull.2010.01.014","article-title":"Lack of sleep affects the evaluation of emotional stimuli","volume":"82","author":"Daniela","year":"2010","journal-title":"Brain Res. Bull."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/07448481.2016.1269111","article-title":"Multilevel analysis exploring the links between stress, depression, and sleep problems among two-year college students","volume":"65","author":"Wallace","year":"2017","journal-title":"J. Am. Coll. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nature04286","article-title":"Sleep-dependent memory consolidation","volume":"437","author":"Stickgold","year":"2005","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/35049064","article-title":"Recognition memory: What are the roles of the perirhinal cortex and hippocampus?","volume":"2","author":"Brown","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-psych-010213-115205","article-title":"Why sleep is important for health: A psychoneuroimmunology perspective","volume":"66","author":"Irwin","year":"2015","journal-title":"Annu. Rev. Psychol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/npp.2016.148","article-title":"Sleep health: Reciprocal regulation of sleep and innate immunity","volume":"42","author":"Irwin","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nabavi, S., Debbarma, S., and Bhadra, S. (2020, January 20\u201324). A smart mandibular advancement device for intraoral cardiorespiratory monitoring. Proceedings of the 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada.","DOI":"10.1109\/EMBC44109.2020.9176520"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hamida, S.T.-B., Hamida, E.B., Ahmed, B., and Abu-Dayya, A. (2013, January 10\u201313). Towards efficient and secure in-home wearable insomnia monitoring and diagnosis system. Proceedings of the 13th IEEE International Conference on BioInformatics and BioEngineering, Chania, Greece.","DOI":"10.1109\/BIBE.2013.6701671"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1109\/JSEN.2018.2791400","article-title":"Wireless wearable magnetometer-based sensor for sleep quality monitoring","volume":"18","author":"Milici","year":"2018","journal-title":"IEEE Sens. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/sleep\/28.4.499","article-title":"Practice parameters for the indications for polysomnography and related procedures: An update for 2005","volume":"28","author":"Kushida","year":"2005","journal-title":"Sleep"},{"key":"ref_13","unstructured":"Berry, R.B., Brooks, R., Gamaldo, C.E., Harding, S.M., Lloyd, R.M., Marcus, C.L., and Vaughn, B.V. (2012). The AASM Manual for the Scoring of Sleep and Associated Events, American Academy of Sleep Medicine."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Boucsein, W. (2012). Electrodermal Activity, Springer Science & Business Media.","DOI":"10.1007\/978-1-4614-1126-0"},{"key":"ref_15","unstructured":"Selye, H. (1956). The Stress of Life, McGraw-Hill."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Miglis, M. (2017). Sleep and the autonomic nervous system. Sleep and Neurologic Disease, Elsevier.","DOI":"10.1016\/B978-0-12-804074-4.00018-2"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijpsycho.2014.09.011","article-title":"Quantitative analysis of wrist electrodermal activity during sleep","volume":"94","author":"Sano","year":"2014","journal-title":"Int. J. Psychophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1469-8986.1967.tb02701.x","article-title":"Nocturnal EEG-GSR profiles: The influence of presleep states","volume":"3","author":"Lester","year":"1967","journal-title":"Psychophysiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1469-8986.1968.tb02826.x","article-title":"Electrodermal levels and fluctuations during normal sleep","volume":"5","author":"Koumans","year":"1968","journal-title":"Psychophysiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S1388-2457(99)00294-1","article-title":"Sleep stage-related changes in sympathetic sudomotor and vasomotor skin responses in man","volume":"111","author":"Liguori","year":"2000","journal-title":"Clin. Neurophysiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1566-0702(02)00261-8","article-title":"Skin sympathetic nerve function during sleep-a study with effector responses","volume":"103","author":"Kobayashi","year":"2003","journal-title":"Auton. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1109\/JBHI.2015.2490480","article-title":"Sleep period time estimation based on electrodermal activity","volume":"21","author":"Hwang","year":"2015","journal-title":"IEEE J. Biomed. Health Inform."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e12694","DOI":"10.1111\/jsr.12694","article-title":"Electrodermal activity patterns in sleep stages and their utility for sleep versus wake classification","volume":"28","author":"Herlan","year":"2019","journal-title":"J. Sleep Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1469-8986.1981.tb03024.x","article-title":"Publication recommendations for electrodermal measurements","volume":"18","author":"Fowles","year":"1981","journal-title":"Psychophysiology"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lam, L.K., and Szypula, A.J. (2018, January 12\u201314). Wearable emotion sensor on flexible substrate for mobile health applications. Proceedings of the IEEE Sensors Applications Symposium (SAS), Seoul, Korea.","DOI":"10.1109\/SAS.2018.8336761"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Garbarino, M., Lai, M., Bender, D., Picard, R.W., and Tognetti, S. (2014, January 3\u20135). Empatica E3-A wearable wireless multi-sensor device for real-time computerized biofeedback and data acquisition. Proceedings of the 4th International Conference on Wireless Mobile Communication and Healthcare-Transforming Healthcare Through Innovations in Mobile and Wireless Technologies (MOBIHEALTH), Athens, Greece.","DOI":"10.4108\/icst.mobihealth.2014.257418"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1901924","DOI":"10.1002\/adma.201901924","article-title":"Advanced soft materials, sensor integrations, and applications of wearable flexible hybrid electronics in healthcare, energy, and environment","volume":"32","author":"Lim","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Herbert, R., Kim, J.-H., Kim, Y.S., Lee, H.M., and Yeo, W.-H. (2018). Soft material-enabled, flexible hybrid electronics for medicine, healthcare, and human-machine interfaces. Materials, 11.","DOI":"10.3390\/ma11020187"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111981","DOI":"10.1016\/j.bios.2019.111981","article-title":"Skin-conformal, soft material-enabled bioelectronic system with minimized motion artifacts for reliable health and performance monitoring of athletes","volume":"151","author":"Kwon","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2000810","DOI":"10.1002\/advs.202000810","article-title":"Fully integrated, stretchable, wireless skin-conformal bioelectronics for continuous stress monitoring in daily life","volume":"7","author":"Kim","year":"2020","journal-title":"Adv. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"112764","DOI":"10.1016\/j.bios.2020.112764","article-title":"Wireless, continuous monitoring of daily stress and management practice via soft bioelectronics","volume":"173","author":"Kim","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-17288-0","article-title":"All-printed nanomembrane wireless bioelectronics using a biocompatible solderable graphene for multimodal human-machine interfaces","volume":"11","author":"Kwon","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"eaay1729","DOI":"10.1126\/sciadv.aay1729","article-title":"Soft, wireless periocular wearable electronics for real-time detection of eye vergence in a virtual reality toward mobile eye therapies","volume":"6","author":"Mishra","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s42256-019-0091-7","article-title":"Fully portable and wireless universal brain\u2013machine interfaces enabled by flexible scalp electronics and deep learning algorithm","volume":"1","author":"Mahmood","year":"2019","journal-title":"Nat. Mach. Intell."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Berry, R.B., Brooks, R., Gamaldo, C., Harding, S.M., Lloyd, R.M., Quan, S.F., Troester, M.T., and Vaughn, B.V. (2017). AASM Scoring Manual Updates for 2017 (Version 2.4), American Academy of Sleep Medicine.","DOI":"10.5664\/jcsm.6576"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1152\/physiol.00062.2015","article-title":"Sleep neurophysiological dynamics through the lens of multitaper spectral analysis","volume":"32","author":"Prerau","year":"2017","journal-title":"Physiology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1002\/adfm.201200498","article-title":"Highly sensitive skin-mountable strain gauges based entirely on elastomers","volume":"22","author":"Lu","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aau0780","article-title":"Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care","volume":"363","author":"Chung","year":"2019","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Romine, W., Banerjee, T., and Goodman, G. (2019). Toward sensor-based sleep monitoring with electrodermal activity measures. Sensors, 19.","DOI":"10.3390\/s19061417"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3389\/fnhum.2016.00605","article-title":"Visualization of whole-night sleep EEG from 2-channel mobile recording device reveals distinct deep sleep stages with differential electrodermal activity","volume":"10","author":"Onton","year":"2016","journal-title":"Front. Hum. Neurosci."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/2\/354\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:07:56Z","timestamp":1760159276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/2\/354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["s21020354"],"URL":"https:\/\/doi.org\/10.3390\/s21020354","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,7]]}}}