{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:44:26Z","timestamp":1778561066265,"version":"3.51.4"},"reference-count":104,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The demand for point-of-need (PON) diagnostics for clinical and other applications is continuing to grow. Much of this demand is currently serviced by biosensors, which combine a bioanalytical sensing element with a transducing device that reports results to the user. Ideally, such devices are easy to use and do not require special skills of the end user. Application-dependent, PON devices may need to be capable of measuring low levels of analytes very rapidly, and it is often helpful if they are also portable. To date, only two transduction modalities, colorimetric lateral flow immunoassays (LFIs) and electrochemical assays, fully meet these requirements and have been widely adopted at the point-of-need. These modalities are either non-quantitative (LFIs) or highly analyte-specific (electrochemical glucose meters), therefore requiring considerable modification if they are to be co-opted for measuring other biomarkers. F\u00f6rster Resonance Energy Transfer (RET)-based biosensors incorporate a quantitative and highly versatile transduction modality that has been extensively used in biomedical research laboratories. RET-biosensors have not yet been applied at the point-of-need despite its advantages over other established techniques. In this review, we explore and discuss recent developments in the translation of RET-biosensors for PON diagnoses, including their potential benefits and drawbacks.<\/jats:p>","DOI":"10.3390\/s21020660","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T03:34:25Z","timestamp":1611113665000},"page":"660","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Resonance Energy Transfer-Based Biosensors for Point-of-Need Diagnosis\u2014Progress and Perspectives"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5822-1904","authenticated-orcid":false,"given":"Felix","family":"Weihs","sequence":"first","affiliation":[{"name":"CSIRO Health &amp; Biosecurity, Parkville, 343 Royal Parade, Melbourne, VIC 3030, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-116X","authenticated-orcid":false,"given":"Alisha","family":"Anderson","sequence":"additional","affiliation":[{"name":"CSIRO Health &amp; Biosecurity, Black Mountain, Canberra, ACT 2600, Australia"}]},{"given":"Stephen","family":"Trowell","sequence":"additional","affiliation":[{"name":"PPB Technology Pty Ltd., Centre for Entrepreneurial Agri-Technology, Australian National University, Canberra, ACT 2601, Australia"}]},{"given":"Karine","family":"Caron","sequence":"additional","affiliation":[{"name":"CSIRO Health &amp; Biosecurity, Black Mountain, Canberra, ACT 2600, Australia"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1586\/14737159.2014.960516","article-title":"Point-of-care diagnostics, a major opportunity for change in traditional diagnostic approaches: Potential and limitations","volume":"14","author":"McPartlin","year":"2014","journal-title":"Expert Rev. 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