{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:45:01Z","timestamp":1760233501983,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper, a novel measurement system based on Quartz Crystal Microbalances is presented. The proposed solution was conceived specifically to overcome the measurement problems related to Quartz Crystal Microbalance (QCM) applications in dielectric liquids where the Q-factor of the resonant system is severely reduced with respect to in-gas applications. The QCM is placed in a Meacham oscillator embedding an amplifier with adjustable gain, an automatic strategy for gain tuning allows for maintaining the oscillator frequency close to the series resonance frequency of the quartz, which is related in a simple way with the physical parameters of interest. The proposed system can be used to monitor simultaneously both the series resonant frequency and the equivalent electromechanical resistance of the quartz. The feasibility and the performance of the proposed method are proven by means of measurements obtained with a prototype based on a 10-MHz AT-cut quartz.<\/jats:p>","DOI":"10.3390\/s21030678","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:53:41Z","timestamp":1611190421000},"page":"678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["An Adaptive Measurement System for the Simultaneous Evaluation of Frequency Shift and Series Resistance of QCM in Liquid"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-1516","authenticated-orcid":false,"given":"Ada","family":"Fort","sequence":"first","affiliation":[{"name":"Department of Information Engineering and Mathematical Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2779-4878","authenticated-orcid":false,"given":"Enza","family":"Panzardi","sequence":"additional","affiliation":[{"name":"Department of Information Engineering and Mathematical Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-6566","authenticated-orcid":false,"given":"Valerio","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Department of Information Engineering and Mathematical Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-5549","authenticated-orcid":false,"given":"Marco","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Information Engineering and Mathematical Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-481X","authenticated-orcid":false,"given":"Elia","family":"Landi","sequence":"additional","affiliation":[{"name":"Department of Information Engineering and Mathematical Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mugnaini","sequence":"additional","affiliation":[{"name":"Department of Information Engineering and Mathematical Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Vaccarella","sequence":"additional","affiliation":[{"name":"Department of Information Engineering and Mathematical Sciences, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alassi, A., Benammar, M., and Brett, D. (2017). Quartz crystal microbalance electronic interfacing systems: A review. Sensors, 17.","DOI":"10.3390\/s17122799"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"065101","DOI":"10.1063\/1.5098451","article-title":"Viscosity measurements in pulsed magnetic fields by using a quartz-crystal microbalance","volume":"90","author":"Nomura","year":"2019","journal-title":"Rev. Sci. Instrum."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sna.2013.12.002","article-title":"New approach for the QCM sensors characterization","volume":"207","year":"2014","journal-title":"Sens. Actuators A Phys."},{"key":"ref_4","unstructured":"Wegener, J. (2018). On the Use of the Quartz Crystal Microbalance for Whole-Cell-Based Biosensing. Label-Free Monitoring of Cells In Vitro, Springer. Bioanalytical Reviews."},{"key":"ref_5","first-page":"243","article-title":"The use of quartz crystal microbalance with dissipation (QCM-D) for studying nanoparticle-induced platelet aggregation","volume":"7","author":"Medina","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1109\/TUFFC.2018.2860597","article-title":"The Exploration and Confirmation of the Maximum Mass Sensitivity of Quartz Crystal Microbalance","volume":"65","author":"Huang","year":"2018","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_7","first-page":"1","article-title":"An AlN Micromachined Mass Sensor: Modeling and Characterization","volume":"70","author":"Fort","year":"2021","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Fort, A., Panzardi, E., Addabbo, T., Mugnaini, M., Vignoli, V., and Trigona, C. (2019, January 11\u201313). Conditioning Circuit for Simultaneous Sensing and Actuation in Piezoelectric MEMS Resonators. Proceedings of the 2019 IEEE Sensors Applications Symposium (SAS), Sophia Antipolis, France.","DOI":"10.1109\/SAS.2019.8705996"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.3390\/s140507602","article-title":"Sensor Applications of Soft Magnetic Materials Based on Magneto-Impedance, Magneto-Elastic Resonance and Magneto-Electricity","volume":"14","author":"Kurlyandskaya","year":"2014","journal-title":"Sensors"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhang, M., Chen, D., and Wang, X. (2019, January 11\u201314). Theoretical Derivation and Verification of Liquid Viscosity and Density Measurements Using Quartz Tuning Fork Sensor. Proceedings of the 2019 13th Symposium on Piezoelectrcity, Acoustic Waves and Device Applications (SPAWDA), Harbin, China.","DOI":"10.1109\/SPAWDA.2019.8681835"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/s20700294","article-title":"Wireless Magnetoelastic Resonance Sensors: A Critical Review","volume":"2","author":"Grimes","year":"2002","journal-title":"Sensors"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez, J., Lasheras, A., Martins, P., Pereira, N., Barandiar\u00e1n, J.M., and Lanceros-Mendez, S. (2017). Metallic Glass\/PVDF Magnetoelectric Laminates for Resonant Sensors and Actuators: A Review. Sensors, 17.","DOI":"10.20944\/preprints201703.0007.v1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Santhosh, K.V., and Prajwal, K. (2017, January 6\u20137). Non-contact viscosity measurement using sensor fusion techniques. Proceedings of the 2017 International Conference on Intelligent Computing, Instrumentation and Control Technologies (ICICICT), Kannur, India.","DOI":"10.1109\/ICICICT1.2017.8342644"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5194\/jsss-6-341-2017","article-title":"Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform","volume":"6","author":"Thies","year":"2017","journal-title":"J. Sens. Sens. Syst."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3390\/s8010370","article-title":"A Review of Interface Electronic Systems for AT-cut Quartz Crystal Microbalance Applications in Liquids","volume":"8","author":"Arnau","year":"2008","journal-title":"Sensors"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF01337937","article-title":"Use of quartz crystals for weighing thin layers and for microweighing","volume":"155","author":"Sauerbrey","year":"1959","journal-title":"Z. Physik."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1109\/TIM.2017.2785118","article-title":"Quartz-crystal microbalance gas sensors based on TiO2 nanoparticles","volume":"67","author":"Addabbo","year":"2018","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0956-5663(02)00050-7","article-title":"Missing mass effect in biosensor\u2019s QCM applications","volume":"17","author":"Voinova","year":"2002","journal-title":"Biosens. Bioelectron."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Liao, S., Ye, P., Tan, F., Chen, J., and Shi, S. (2018, January 21\u201324). Method for Measuring the Properties of Liquid by a Single QCM at Different Temperatures. Proceedings of the 2018 IEEE International Frequency Control Symposium (IFCS), Olympic Valley, CA, USA.","DOI":"10.1109\/FCS.2018.8597558"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ahumada, L.A., Gonz\u00e1lez, M.X., Sandoval, O.L., and Olmedo, J.J. (2016). Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases. Sensors, 16.","DOI":"10.3390\/s16111959"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cis.2015.10.004","article-title":"QCM-D study of nanoparticle interactions","volume":"233","author":"Chen","year":"2016","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00216-003-2081-0","article-title":"Simultaneous measurement of the maximum oscillation amplitude and the transient decay time constant of the QCM reveals stiffness changes of the adlayer","volume":"377","author":"Bissig","year":"2003","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.snb.2012.10.013","article-title":"Functional characterization of starch-degrading enzymes using quartz crystal microbalance with dissipation monitoring (QCM-D)","volume":"176","author":"Armand","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1109\/58.949746","article-title":"An extended Butterworth Van Dyke model for quartz crystal microbalance applications in viscoelastic fluid media","volume":"48","author":"Arnau","year":"2001","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1021\/ac00285a062","article-title":"Frequency of a quartz microbalance in contact with liquid","volume":"57","author":"Kanazawa","year":"1985","journal-title":"Anal. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/j.1538-7305.1938.tb00799.x","article-title":"The bridge stabilized oscillator","volume":"17","author":"Meacham","year":"1938","journal-title":"Bell Syst. Tech. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"083905","DOI":"10.1063\/1.3202207","article-title":"A nanocell for quartz crystal microbalance and quartz crystal microbalance with dissipation-monitoring sensing","volume":"80","author":"Ohlsson","year":"2009","journal-title":"Rev. Sci. 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