{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T13:53:32Z","timestamp":1767880412677,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004358","name":"Samsung","doi-asserted-by":"publisher","award":["SRFC-MA1502-51"],"award-info":[{"award-number":["SRFC-MA1502-51"]}],"id":[{"id":"10.13039\/100004358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 \u03bcL of extracted plasma with a high extraction yield (~45%) in 16 min.<\/jats:p>","DOI":"10.3390\/s21041366","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T05:52:49Z","timestamp":1613368369000},"page":"1366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device"],"prefix":"10.3390","volume":"21","author":[{"given":"Jaehoon","family":"Kim","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Korea University, Seoul 02841, Korea"}]},{"given":"Junghyo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA"}]},{"given":"Jae-Yeong","family":"Byun","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University, Seoul 02841, Korea"}]},{"given":"Hyunho","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University, Seoul 02841, Korea"}]},{"given":"Sewoon","family":"Han","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University, Seoul 02841, Korea"}]},{"given":"Junghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University, Seoul 02841, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7344-6060","authenticated-orcid":false,"given":"Jeong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, School of Electronics and Information Technology, Kwangwoon University, Seoul 01886, Korea"}]},{"given":"Han-Sang","family":"Jo","sequence":"additional","affiliation":[{"name":"Absology, Digitalempire B-dong, 383, Simin-daero, Dongan-gu, Anyang-si, Gyeonggi-do 14057, Korea"}]},{"given":"Seok","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Korea University, Seoul 02841, Korea"},{"name":"KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nnano.2009.353","article-title":"Label-Free biomarker detection from whole blood","volume":"5","author":"Stern","year":"2010","journal-title":"Nat. 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