{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:56:06Z","timestamp":1774061766417,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health\/Centers for Disease Control and Prevention to the University of Pittsburgh CAPH-PRC that funded the MOVEUP study","award":["5U48DP005001"],"award-info":[{"award-number":["5U48DP005001"]}]},{"name":"The Pittsburgh Claude D. Pepper Older Americans Independence Center, Research Registry and Developmental Pilot Grant","award":["NIH P30 AG024827"],"award-info":[{"award-number":["NIH P30 AG024827"]}]},{"name":"National Institute on Aging Professional Services Contract for supporting DECOS","award":["HHSN271201100605P"],"award-info":[{"award-number":["HHSN271201100605P"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Physical activity (PA) is associated with greater fatigability in older adults; little is known about magnitude, shape, timing and variability of the entire 24-h rest\u2013activity rhythm (RAR) associated with fatigability. We identified which features of the 24-h RAR pattern were independently and jointly associated with greater perceived physical fatigability (Pittsburgh Fatigability Scale, PFS, 0\u201350) in older adults (n = 181, 71.3 \u00b1 6.7 years). RARs were characterized using anti-logistic extended cosine models and 4-h intervals of PA means and standard deviations across days. A K-means clustering algorithm approach identified four profiles of RAR features: \u201cLess Active\/Robust\u201d, \u201cEarlier Risers\u201d, \u201cMore Active\/Robust\u201d and \u201cLater RAR\u201d. Quantile regression tested associations of each RAR feature\/profile on median PFS adjusted for age, sex, race, body mass index and depression symptomatology. Later rise times (up mesor; \u03b2 = 1.38, p = 0.01) and timing of midpoint of activity (acrophase; \u03b2 = 1.29, p = 0.01) were associated with higher PFS scores. Lower PA between 4 a.m. and 8 a.m. was associated with higher PFS scores (\u03b2 = \u22124.50, p = 0.03). \u201cLess Active\/Robust\u201d (\u03b2 = 6.14, p = 0.01) and \u201cLater RAR\u201d (\u03b2 = 3.53, p = 0.01) patterns were associated with higher PFS scores compared to \u201cEarlier Risers\u201d. Greater physical fatigability in older adults was associated with dampened, more variable, and later RARs. This work can guide development of interventions aimed at modifying RARs to reduce fatigability in older adults.<\/jats:p>","DOI":"10.3390\/s21051718","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:36:37Z","timestamp":1614681397000},"page":"1718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Profiles of Accelerometry-Derived Physical Activity Are Related to Perceived Physical Fatigability in Older Adults"],"prefix":"10.3390","volume":"21","author":[{"given":"Jessica L.","family":"Graves","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA"}]},{"given":"Yujia (Susanna)","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA"}]},{"given":"Kyle D.","family":"Moored","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA"}]},{"given":"Robert M.","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA"}]},{"given":"Elizabeth M.","family":"Venditti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA"}]},{"given":"Robert T.","family":"Krafty","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA"}]},{"given":"Eric J.","family":"Shiroma","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD 21225, USA"}]},{"given":"Jaroslaw","family":"Harezlak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN 47405, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-0162","authenticated-orcid":false,"given":"Nancy W.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.pmrj.2010.03.022","article-title":"Fatigue and fatigability in older adults","volume":"2","author":"Eldadah","year":"2010","journal-title":"PM&R"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1093\/gerona\/glaa185","article-title":"Fatigability: A prognostic indicator of phenotypic aging","volume":"75","author":"Schrack","year":"2020","journal-title":"J. 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