{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:38:12Z","timestamp":1773351492197,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16IRG26960017"],"award-info":[{"award-number":["16IRG26960017"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"Army Research Office","doi-asserted-by":"publisher","award":["W911NNF-14-D-0005"],"award-info":[{"award-number":["W911NNF-14-D-0005"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01HD091283"],"award-info":[{"award-number":["K01HD091283"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Stroke is a leading cause of long-term disability in the United States. Recent studies have shown that high doses of repeated task-specific practice can be effective at improving upper-limb function at the chronic stage. Providing at-home telerehabilitation services with therapist supervision may allow higher dose interventions targeted to this population. Additionally, muscle biofeedback to train patients to avoid unwanted simultaneous activation of antagonist muscles (co-contractions) may be incorporated into telerehabilitation technologies to improve motor control. Here, we present the development and feasibility of a low-cost, portable, telerehabilitation biofeedback system called Tele-REINVENT. We describe our modular electromyography acquisition, processing, and feedback algorithms to train differentiated muscle control during at-home therapist-guided sessions. Additionally, we evaluated the performance of low-cost sensors for our training task with two healthy individuals. Finally, we present the results of a case study with a stroke survivor who used the system for 40 sessions over 10 weeks of training. In line with our previous research, our results suggest that using low-cost sensors provides similar results to those using research-grade sensors for low forces during an isometric task. Our preliminary case study data with one patient with stroke also suggest that our system is feasible, safe, and enjoyable to use during 10 weeks of biofeedback training, and that improvements in differentiated muscle activity during volitional movement attempt may be induced during a 10-week period. Our data provide support for using low-cost technology for individuated muscle training to reduce unintended coactivation during supervised and unsupervised home-based telerehabilitation for clinical populations, and suggest this approach is safe and feasible. Future work with larger study populations may expand on the development of meaningful and personalized chronic stroke rehabilitation.<\/jats:p>","DOI":"10.3390\/s21051806","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T05:03:15Z","timestamp":1614920595000},"page":"1806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Development of a Low-Cost, Modular Muscle\u2013Computer Interface for At-Home Telerehabilitation for Chronic Stroke"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-254X","authenticated-orcid":false,"given":"Octavio","family":"Marin-Pardo","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 900089, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coralie","family":"Phanord","sequence":"additional","affiliation":[{"name":"Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA 900089, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda Rennie","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA 900089, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Laine","sequence":"additional","affiliation":[{"name":"Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA 900089, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-4215","authenticated-orcid":false,"given":"Sook-Lei","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 900089, USA"},{"name":"Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA 900089, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Virani, S.S., Alonso, A., Benjamin, E.J., Bittencourt, M.S., Callaway, C.W., Carson, A.P., Chamberlain, A.M., Chang, A.R., Cheng, S., and Delling, F.N. 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