{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:52:26Z","timestamp":1760233946479,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>High intraocular pressure (IOP) is one of the major risk factors for glaucoma, and thus accurate IOP measurements should be performed to diagnose and treat glaucoma early. In this study, a novel technique for measuring the IOP based on acoustic radiation force was proposed, and its potential was experimentally demonstrated. The proposed technique uses the acoustic radiation force to generate axial displacement on the ocular surface while simultaneously measuring the degree of deformation. In order to verify that the ocular displacement induced by the acoustic radiation force is related to the IOP, the experiment was conducted by fabricating a 5 MHz single element transducer and gelatin phantoms with different stiffness values. Our experimental results show that there is a close relationship between the ocular displacement by the acoustic radiation force and the IOP obtained by a commercial tonometer. Therefore, the proposed acoustic radiation force technique can be a promising candidate for measuring the IOP.<\/jats:p>","DOI":"10.3390\/s21051857","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T21:52:15Z","timestamp":1615153935000},"page":"1857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Intraocular Pressure Measurement Technique Based on Acoustic Radiation Force Using an Ultrasound Transducer: A Feasibility Study"],"prefix":"10.3390","volume":"21","author":[{"given":"Hee Su","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology, Dongguk University, Seoul 04620, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Dongguk University, Seoul 04620, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ho","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Dongguk University, Seoul 04620, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Dongguk University, Seoul 04620, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Seob","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Dongguk University, Seoul 04620, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of people with glaucoma worldwide","volume":"80","author":"Quigley","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"ref_2","first-page":"887","article-title":"Glaucoma is second leading cause of blindness globally","volume":"82","author":"Kingman","year":"2004","journal-title":"Bull. World Health Organ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","article-title":"Neuronal death in glaucoma","volume":"18","author":"Quigley","year":"1999","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.ophtha.2005.01.042","article-title":"Intraocular pressure\u2013lowering effects of all commonly used glaucoma drugs: A meta-analysis of randomized clinical trials","volume":"112","author":"Webers","year":"2005","journal-title":"Ophthalmology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.ophtha.2007.04.003","article-title":"Incident open-angle glaucoma and intraocular pressure","volume":"114","author":"Nemesure","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0161-6420(97)30067-0","article-title":"Reappraising the risks and benefits of aggressive glaucoma therapy","volume":"104","author":"Quigley","year":"1997","journal-title":"Ophthalmology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00061198-200306000-00009","article-title":"24-hour monitoring of intraocular pressure in glaucoma management: A retrospective review","volume":"12","author":"Hughes","year":"2003","journal-title":"J. Glaucoma"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000303213","article-title":"\u00dcber applanationstonometrie","volume":"134","author":"Goldmann","year":"1957","journal-title":"Ophthalmologica"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0039-6257(93)90053-A","article-title":"Sources of error with use of Goldmann-type tonometers","volume":"38","author":"Whitacre","year":"1993","journal-title":"Surv. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1442-9071.2009.02109.x","article-title":"The iCare rebound tonometer: Comparisons with Goldmann tonometry, and influence of central corneal thickness","volume":"37","author":"Poostchi","year":"2009","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/bjo.2005.089870","article-title":"Comparison of rebound tonometry with Goldmann applanation tonometry and correlation with central corneal thickness","volume":"90","author":"Iliev","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0161-6420(96)30741-0","article-title":"Standardizing the measurement of intraocular pressure for clinical research: Guidelines from the Eye Care Technology Forum","volume":"103","author":"Kass","year":"1996","journal-title":"Ophthalmology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1167\/iovs.04-0018","article-title":"Comparison of dynamic contour tonometry with Goldmann applanation tonometry","volume":"45","author":"Kaufmann","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF02569066","article-title":"A new electromechanical method for measuring intraocular pressure","volume":"93","author":"Kontiola","year":"1997","journal-title":"Doc. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-0420.2005.00610.x","article-title":"Clinical evaluation of rebound tonometer","volume":"84","author":"Davies","year":"2006","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1475-1313.2005.00327.x","article-title":"Comparison of the ICare\u00ae rebound tonometer with the Goldmann tonometer in a normal population","volume":"25","author":"Fernandes","year":"2005","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/sj.eye.6702669","article-title":"Comparison of the ICares rebound tonometer with the Goldmann applanation tonometer by experienced and inexperienced tonometrists","volume":"22","author":"Abraham","year":"2008","journal-title":"Eye"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/IJG.0b013e318133fb32","article-title":"Clinical comparison of the Icare tonometer and Goldmann applanation tonometry","volume":"17","author":"Pakrou","year":"2008","journal-title":"J. Glaucoma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ajo.2006.02.035","article-title":"Agreement of rebound tonometer in measuring intraocular pressure with three types of applanation tonometers","volume":"142","author":"Nakamura","year":"2006","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/01.ijg.0000212208.87523.66","article-title":"Comparison of ICare tonometer with Goldmann applanation tonometer in glaucoma patients","volume":"15","author":"Brusini","year":"2006","journal-title":"J. Glaucoma"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0039-6257(80)90042-9","article-title":"The non-contact tonometer. Its value and limitations","volume":"24","author":"Shields","year":"1980","journal-title":"Surv. Ophthalmol."},{"key":"ref_23","first-page":"310","article-title":"Assessment of the accuracy and reliability of the Topcon CT80 non-contact tonometer","volume":"89","author":"Ogbuehi","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/eye.1993.26","article-title":"Comparison of the Keeler Pulsair 2000 non-contact tonometer with Goldmann applanation","volume":"7","author":"Moseley","year":"1993","journal-title":"Eye"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/00006324-197208000-00005","article-title":"A new tonometer system","volume":"49","author":"Grolman","year":"1972","journal-title":"Optom. Vis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/bjo.2004.056622","article-title":"The influence of central corneal thickness and age on intraocular pressure measured by pneumotonometry, non-contact tonometry, the Tono-Pen XL, and Goldmann applanation tonometry","volume":"89","author":"Tonnu","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0021-5155(00)00250-1","article-title":"The influence of corneal thickness and curvature on the difference between intraocular pressure measurements obtained with a non-contact tonometer and those with a Goldmann applanation tonometer","volume":"44","author":"Matsumoto","year":"2000","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0301-5629(01)00499-9","article-title":"Acoustic radiation force impulse imaging: In vivo demonstration of clinical feasibility","volume":"28","author":"Nightingale","year":"2002","journal-title":"Ultrasound Med. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1109\/TUFFC.2005.1561624","article-title":"A finite-element method model of soft tissue response to impulsive acoustic radiation force","volume":"52","author":"Palmeri","year":"2005","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ultrasmedbio.2015.03.009","article-title":"WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 1: Basic principles and terminology","volume":"41","author":"Shiina","year":"2015","journal-title":"Ultrasound Med. Biol."},{"key":"ref_31","unstructured":"Palmeri, M.L. (2005). Imaging the Mechanical Properties of Tissue with Ultrasound: An Investigation of the Response of Soft Tissue to Acoustic Radiation Force, Duke University."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1109\/TUFFC.2003.1209550","article-title":"Estimates of echo correlation and measurement bias in acoustic radiation force impulse imaging","volume":"50","author":"McAleavey","year":"2003","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1109\/TUFFC.2006.1642509","article-title":"Rapid tracking of small displacements with ultrasound","volume":"53","author":"Pinton","year":"2006","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ultrasmedbio.2005.08.008","article-title":"Analysis of contrast in images generated with transient acoustic radiation force","volume":"32","author":"Nightingale","year":"2006","journal-title":"Ultrasound Med. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/016173460002200103","article-title":"A finite element model of remote palpation of breast lesions using radiation force: Factors affecting tissue displacement","volume":"22","author":"Nightingale","year":"2000","journal-title":"Ultrason. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/05704928.2018.1467436","article-title":"Acoustic radiation force optical coherence elastography for elasticity assessment of soft tissues","volume":"54","author":"Zhu","year":"2019","journal-title":"Appl. Spectrosc. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1109\/JSTQE.2016.2524618","article-title":"Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue","volume":"22","author":"Qu","year":"2016","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1109\/JSTQE.2013.2291445","article-title":"A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects","volume":"20","author":"Kennedy","year":"2014","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jbio.201400108","article-title":"Optical coherence elastography for tissue characterization: A review","volume":"8","author":"Wang","year":"2015","journal-title":"J. Biophotonics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1167\/iovs.17-22971","article-title":"In Vivo Elasticity Mapping of Posterior Ocular Layers Using Acoustic Radiation Force Optical Coherence Elastography","volume":"59","author":"Qu","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1121\/1.1378344","article-title":"On the feasibility of remote palpation using acoustic radiation force","volume":"110","author":"Nightingale","year":"2001","journal-title":"J. Acoust. Soc. Am."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1119\/1.13625","article-title":"The acoustic radiation force","volume":"52","author":"Torr","year":"1984","journal-title":"Am. J. Phys."},{"key":"ref_43","unstructured":"Young, W.C., and Budynas, R.G. (2002). Roark\u2019s Formulas for Stress and Strain, McGraw-Hill Publication. [7th ed.]."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1006\/bulm.1999.0102","article-title":"Determination of the true intraocular pressure and modulus of elasticity of the human cornea in vivo","volume":"61","author":"Orssengo","year":"1999","journal-title":"Bull. Math. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jcrs.2004.09.031","article-title":"Influence of corneal biomechanical properties on intraocular pressure measurement: Quantitative analysis","volume":"31","author":"Liu","year":"2005","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0021-9290(71)90053-4","article-title":"Analysis of the corneo-scleral shell by the method of direct stiffness","volume":"4","author":"Kobayashi","year":"1971","journal-title":"J. Biomech."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1034\/j.1600-0420.2002.800103.x","article-title":"Central corneal thickness, radius of the corneal curvature and intraocular pressure in normal subjects using non-contact techniques: Reykjavik Eye Study","volume":"80","author":"Eysteinsson","year":"2002","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1001\/archopht.1997.01100160307007","article-title":"Central corneal thickness in normal, glaucomatous, and ocular hypertensive eyes","volume":"115","author":"Herndon","year":"1997","journal-title":"Arch. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0002-9394(14)71125-0","article-title":"Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study","volume":"123","author":"Wolfs","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/sapm194625180","article-title":"Stresses and small displacements of shallow spherical shells. II","volume":"25","author":"Reissner","year":"1946","journal-title":"J. Math. Phys."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1109\/JSEN.2020.3021584","article-title":"Improved acoustic radiation force impulse imaging using split-focused ultrasound transducer with phase inversion technique","volume":"21","author":"Jeong","year":"2021","journal-title":"IEEE Sens. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"121503","DOI":"10.1117\/1.JBO.18.12.121503","article-title":"Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo","volume":"18","author":"Li","year":"2013","journal-title":"J. Biomed. Opt."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110502","DOI":"10.1117\/1.JBO.19.11.110502","article-title":"Differentiating untreated and cross-linked porcine corneas of the same measured stiffness with optical coherence elastography","volume":"19","author":"Li","year":"2014","journal-title":"J. Biomed. Opt."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1038\/s41467-019-12803-4","article-title":"Reverberant 3D optical coherence elastography maps the elasticity of individual corneal layers","volume":"10","author":"Zvietcovich","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/5\/1857\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:34:19Z","timestamp":1760160859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/5\/1857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,7]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["s21051857"],"URL":"https:\/\/doi.org\/10.3390\/s21051857","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2021,3,7]]}}}