{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:23:09Z","timestamp":1764588189084,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RGC of HKSAR","award":["T42-103\/16N"],"award-info":[{"award-number":["T42-103\/16N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U\/mL, possessing a sensitivity of 7.029 \u00b5AU\u22121mLcm\u22122 with a linear regression (R2) of 0.965 and a lower detection limit of 4 U\/mL. This device has integrated advantages including high specificity and sensitivity and being simple, portable, and cost effective, which collectively enables a giant leap for cancer screening technologies towards clinical use. This is the first report to use RNA aptamers to detect CA72-4 for gastric carcinoma diagnosis.<\/jats:p>","DOI":"10.3390\/s21082639","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:52:00Z","timestamp":1618206720000},"page":"2639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-9305","authenticated-orcid":false,"given":"Saw-Lin","family":"Oo","sequence":"first","affiliation":[{"name":"State Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishir","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"State Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6734-8448","authenticated-orcid":false,"given":"Vaithinathan","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement Manohar","family":"Arava","sequence":"additional","affiliation":[{"name":"State Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spoorthy","family":"Pathikonda","sequence":"additional","affiliation":[{"name":"Department of Physics, City University of Hong Kong, Kowloon, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K. N.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physics, City University of Hong Kong, Kowloon, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-7306","authenticated-orcid":false,"given":"Terrence C. K.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, City University of Hong Kong, Kowloon, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-2756","authenticated-orcid":false,"given":"Xianfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering, School of Engineering, The University of Edinburgh, King\u2019s Buildings, Mayfield Road, Edinburgh EH9 3JL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vellaisamy A. L.","family":"Roy","sequence":"additional","affiliation":[{"name":"James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"ref_1","unstructured":"International Agency for Research on Cancer, WHO (2018). Latest Global Cancer Data: Cancer Burden Rises to 18.1 Million New Cases and 9.6 Million Cancer Deaths in 2018, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1136\/bmj.309.6970.1689","article-title":"Effect of ale, garlic, and soured cream on the appetite of leeches","volume":"309","author":"Baerheim","year":"1994","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Arya, S.K., and Estrela, P. (2018). Recent Advances in Enhancement Strategies for Electrochemical ELISA-Based Immunoassays for Cancer Biomarker Detection. 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