{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:35:46Z","timestamp":1780616146771,"version":"3.54.1"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Physical and Rehabilitation Medicine Society","award":["1"],"award-info":[{"award-number":["1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Background: Walking disorders represent the most disabling condition in persons with Multiple Sclerosis (PwMS). Several studies showed good reliability of the 6-min walk test (6MWT) (i.e., especially distance traveled), but little is known about the reliability of the Spatio-temporal (ST) variables in the 6MWT. Objective: To evaluate the test-retest reliability of ST variables and perceived exertion during the 6MWT in PwMS and comparable healthy persons. Methods: We explored three 1-min intervals (initial: 0\u2032\u20131\u2032, middle: 2\u203230\u2033\u20133\u203230\u2033, end: 5\u2032\u20136\u2032) of the 6MWT. Six ST variables and perceived exertion were measured (respectively, using the GAITRite system and the Borg Scale). These measurements were performed twice, 1 week apart. The test-retest effects were assessed using the intraclass correlation coefficient (ICC) or the weighted kappa. Results: Forty-five PwMS and 24 healthy persons were included. The test-retest reliability of ST variables values was good-to-excellent for PwMS (ICC range: 0.858\u20130.919) and moderate-to-excellent for healthy persons (ICC range: 0.569\u20130.946). The test-retest reliability values of perceived exertion were fair for PwMS (weighted kappa range: 0.279\u20130.376) and substantial for healthy persons (weighted kappa range: 0.734\u20130.788). Conclusion: The measurement of ST variables during these 6MWT intervals is reliable and applicable in clinical practice and research to adapt rehabilitation care in PwMS.<\/jats:p>","DOI":"10.3390\/s21093075","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T22:29:07Z","timestamp":1619648947000},"page":"3075","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of Prolonged Walking in Persons with Multiple Sclerosis: Reliability of the Spatio-Temporal Walking Variables during the 6-Minute Walk Test"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-5593","authenticated-orcid":false,"given":"Nawale","family":"Hadouiri","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Functional Exploration of Movement, University Hospital of Besan\u00e7on, F-25000 Besan\u00e7on, France"},{"name":"Clinical Investigation Center, University Hospital of Besan\u00e7on, INSERM 1431, F-25000 Besan\u00e7on, France"},{"name":"Department of Physical Medicine and Rehabilitation, Dijon-Bourgogne University Hospital, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-2579","authenticated-orcid":false,"given":"Elisabeth","family":"Monnet","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, University Hospital of Besan\u00e7on, INSERM 1431, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-8448","authenticated-orcid":false,"given":"Arnaud","family":"Gouelle","sequence":"additional","affiliation":[{"name":"Gait and Balance Academy, ProtoKinetics, Havertown, PA 19083, USA"},{"name":"Laboratory Performance, Sant\u00e9, M\u00e9trologie, Soci\u00e9t\u00e9 (EA7507), UFR STAPS, F-51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-7171","authenticated-orcid":false,"given":"Pierre","family":"Decavel","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Functional Exploration of Movement, University Hospital of Besan\u00e7on, F-25000 Besan\u00e7on, France"},{"name":"Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, F-25000 Besan\u00e7on, France"},{"name":"Rehabilitation Department, HFR, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Functional Exploration of Movement, University Hospital of Besan\u00e7on, F-25000 Besan\u00e7on, France"},{"name":"Clinical Investigation Center, University Hospital of Besan\u00e7on, INSERM 1431, F-25000 Besan\u00e7on, France"},{"name":"Integrative and Clinical Neurosciences EA481, Bourgogne Franche-Comte University, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1212\/WNL.33.12.1537","article-title":"Multiple sclerosis after age 50","volume":"33","author":"Noseworthy","year":"1983","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jns.2018.02.026","article-title":"Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? 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