{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:59:00Z","timestamp":1760234340669,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["APOSTD\/2019\/086"],"award-info":[{"award-number":["APOSTD\/2019\/086"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["695536"],"award-info":[{"award-number":["695536"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this work, we propose and analyze a new concept of gamma ray imaging that corresponds to a gamma camera with a mobile collimator, which can be used in vivo, during surgical interventions for oncological patients for localizing regions of interest such as tumors or ganglia. The benefits are a much higher sensitivity, better image quality and, consequently, a dose reduction for the patient and medical staff. This novel approach is a practical solution to the overlapping problem which is inherent to multi-pinhole gamma camera imaging and single photon emission computed tomography and which translates into artifacts and\/or image truncation in the final reconstructed image. The key concept consists in introducing a relative motion between the collimator and the detector. Moreover, this design could also be incorporated into most commercially available gamma camera devices, without any excessive additional requirements. We use Monte Carlo simulations to assess the feasibility of such a device, analyze three possible designs and compare their sensitivity, resolution and uniformity. We propose a final design of a gamma camera with a high sensitivity ranging from 0.001 to 0.006 cps\/Bq, and a high resolution of 0.5\u20131.0 cm (FWHM), for source-to-detector distances of 4\u201310 cm. Additionally, this planar gamma camera provides information about the depth of source (with approximate resolution of 1.5 cm) and excellent image uniformity.<\/jats:p>","DOI":"10.3390\/s21103367","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T22:46:14Z","timestamp":1620859574000},"page":"3367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gamma Camera Imaging with Rotating Multi-Pinhole Collimator. A Monte Carlo Feasibility Study"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-3539","authenticated-orcid":false,"given":"Victor","family":"Ilisie","sequence":"first","affiliation":[{"name":"Centro Mixto CSIC, Instituto de Instrumentaci\u00f3n para Imagen Molecular (i3M), Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera, s\/n, 46022 Valencia, Spain"}]},{"given":"Laura","family":"Moliner","sequence":"additional","affiliation":[{"name":"Centro Mixto CSIC, Instituto de Instrumentaci\u00f3n para Imagen Molecular (i3M), Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera, s\/n, 46022 Valencia, Spain"}]},{"given":"Constantino","family":"Morera","sequence":"additional","affiliation":[{"name":"Oncovision, S. A.-Jeronimo de Monsoriu, 92, 46012 Valencia, Spain"}]},{"given":"Johan","family":"Nuyts","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, KULeuven, B3000 Leuven, Belgium"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Benlloch","sequence":"additional","affiliation":[{"name":"Centro Mixto CSIC, Instituto de Instrumentaci\u00f3n para Imagen Molecular (i3M), Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera, s\/n, 46022 Valencia, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11307-018-1227-6","article-title":"Emerging Intraoperative Imaging Modalities to Improve Surgical Precision","volume":"20","author":"Alam","year":"2018","journal-title":"Mol. 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