{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T19:46:05Z","timestamp":1784317565197,"version":"3.55.0"},"reference-count":86,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper, a highly sensitive graphene-based multiple-layer (BK7\/Au\/PtSe2\/Graphene) coated surface plasmon resonance (SPR) biosensor is proposed for the rapid detection of the novel Coronavirus (COVID-19). The proposed sensor was modeled on the basis of the total internal reflection (TIR) technique for real-time detection of ligand-analyte immobilization in the sensing region. The refractive index (RI) of the sensing region is changed due to the interaction of different concentrations of the ligand-analyte, thus impacting surface plasmon polaritons (SPPs) excitation of the multi-layer sensor interface. The performance of the proposed sensor was numerically investigated by using the transfer matrix method (TMM) and the finite-difference time-domain (FDTD) method. The proposed SPR biosensor provides fast and accurate early-stage diagnosis of the COVID-19 virus, which is crucial in limiting the spread of the pandemic. In addition, the performance of the proposed sensor was investigated numerically with different ligand-analytes: (i) the monoclonal antibodies (mAbs) as ligand and the COVID-19 virus spike receptor-binding domain (RBD) as analyte, (ii) the virus spike RBD as ligand and the virus anti-spike protein (IgM, IgG) as analyte and (iii) the specific probe as ligand and the COVID-19 virus single-standard ribonucleic acid (RNA) as analyte. After the investigation, the sensitivity of the proposed sensor was found to provide 183.33\u00b0\/refractive index unit (RIU) in SPR angle (\u03b8SPR) and 833.33THz\/RIU in SPR frequency (SPRF) for detection of the COVID-19 virus spike RBD; the sensitivity obtained 153.85\u00b0\/RIU in SPR angle and 726.50THz\/RIU in SPRF for detection of the anti-spike protein, and finally, the sensitivity obtained 140.35\u00b0\/RIU in SPR angle and 500THz\/RIU in SPRF for detection of viral RNA. It was observed that whole virus spike RBD detection sensitivity is higher than that of the other two detection processes. Highly sensitive two-dimensional (2D) materials were used to achieve significant enhancement in the Goos-H\u00e4nchen (GH) shift detection sensitivity and plasmonic properties of the conventional SPR sensor. The proposed sensor successfully senses the COVID-19 virus and offers additional (1 + 0.55) \u00d7 L times sensitivity owing to the added graphene layers. Besides, the performance of the proposed sensor was analyzed based on detection accuracy (DA), the figure of merit (FOM), signal-noise ratio (SNR), and quality factor (QF). Based on its performance analysis, it is expected that the proposed sensor may reduce lengthy procedures, false positive results, and clinical costs, compared to traditional sensors. The performance of the proposed sensor model was checked using the TMM algorithm and validated by the FDTD technique.<\/jats:p>","DOI":"10.3390\/s21103491","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T12:19:57Z","timestamp":1621253997000},"page":"3491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-6544","authenticated-orcid":false,"given":"Tarik Bin Abdul","family":"Akib","sequence":"first","affiliation":[{"name":"Department of Electrical and Electronic Engineering, Rajshahi University of Engineering and Technology, Rajshahi 6204, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia Ferdous","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering, Rajshahi University of Engineering and Technology, Rajshahi 6204, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Motiur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering, Rajshahi University of Engineering and Technology, Rajshahi 6204, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Masud","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering, Rajshahi University of Engineering and Technology, Rajshahi 6204, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3133-9333","authenticated-orcid":false,"given":"Md. Rabiul","family":"Islam","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Information Sciences, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-9750","authenticated-orcid":false,"given":"Ibrahim M.","family":"Mehedi","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering (ECE) and Center of Excellence in Intelligent Engineering Systems (CEIES), King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1905-6800","authenticated-orcid":false,"given":"M. A. Parvez","family":"Mahmud","sequence":"additional","affiliation":[{"name":"School of Engineering, Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-1214","authenticated-orcid":false,"given":"Abbas Z.","family":"Kouzani","sequence":"additional","affiliation":[{"name":"School of Engineering, Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2019). Novel Coronavirus 2019 (COVID-19), World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.dsx.2020.04.020","article-title":"Ysrafil Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response","volume":"14","author":"Astuti","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1074\/jbc.C300520200","article-title":"A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2","volume":"279","author":"Wong","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41401-020-0485-4","article-title":"Structural and functional properties of SARS-CoV-2 spike protein: Potential antivirus drug development for COVID-19","volume":"41","author":"Huang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","article-title":"Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System","volume":"126","author":"Gheblawi","year":"2020","journal-title":"Circ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0140-6736(20)32623-4","article-title":"Oxford\u2013AstraZeneca COVID-19 vaccine efficacy","volume":"397","author":"Knoll","year":"2021","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(20)32661-1","article-title":"Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: An interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK","volume":"397","author":"Voysey","year":"2021","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"m4857","DOI":"10.1136\/bmj.m4857","article-title":"Covid-19: New coronavirus variant is identified in UK","volume":"371","author":"Wise","year":"2020","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112349","DOI":"10.1016\/j.bios.2020.112349","article-title":"Diagnostic methods and potential portable biosensors for coronavirus disease 2019","volume":"165","author":"Cui","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Cui, H., Song, W., Ru, X., Zhou, W., and Yu, X. (2020). A simple magnetic nanoparticles-based viral RNA extraction method for efficient detection of SARS-CoV-2. bioRxiv.","DOI":"10.1101\/2020.02.22.961268"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e01136","DOI":"10.1002\/cti2.1136","article-title":"Detection of IgM and IgG antibodies in patients with coronavirus disease 2019","volume":"9","author":"Hou","year":"2020","journal-title":"Clin. Transl. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/jmv.25727","article-title":"Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4142\/jvs.2010.11.2.165","article-title":"Production of specific antibodies against SARS-coronavirus nucleocapsid protein without cross reactivity with human coronaviruses 229E and OC43","volume":"11","author":"Lee","year":"2010","journal-title":"J. Vet. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"104500","DOI":"10.1016\/j.jcv.2020.104500","article-title":"Evaluation of rapid antigen test for detection of SARS-CoV-2 virus","volume":"129","author":"Mak","year":"2020","journal-title":"J. Clin. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"114024","DOI":"10.1016\/j.jviromet.2020.114024","article-title":"Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit","volume":"288","author":"Cornelissen","year":"2021","journal-title":"J. Virol. Methods"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2001377","DOI":"10.1183\/13993003.01377-2020","article-title":"Added value of chest computed tomography in suspected COVID-19: An analysis of 239 patients","volume":"56","author":"Korevaar","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e20837","DOI":"10.1097\/MD.0000000000020837","article-title":"Chest CT of COVID-19 in patients with a negative first RT-PCR test","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1021\/acsnano.0c02439","article-title":"Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection","volume":"14","author":"Qiu","year":"2020","journal-title":"ACS Nano"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-01615-8","article-title":"A comprehensive review on plasmonic-based biosensors used in viral diagnostics","volume":"4","author":"Shrivastav","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-020-02369-0","article-title":"Biosensors: Frontiers in rapid detection of COVID-19","volume":"10","author":"Samson","year":"2020","journal-title":"3 Biotech"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Taha, B.A., Al Mashhadany, Y., Mokhtar, M.H.H., Bin Zan, M.S.D., and Arsad, N. (2020). An Analysis Review of Detection Coronavirus Disease 2019 (COVID-19) Based on Biosensor Application. Sensors, 20.","DOI":"10.20944\/preprints202008.0597.v1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s13320-019-0556-7","article-title":"Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection: A Numerical Design-Based Analysis","volume":"10","author":"Hossain","year":"2019","journal-title":"Photon Sens."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Akib, T.B.A., and Hossain, B. (2019, January 11\u201312). Superior Performance of Surface Plasmon Resonance Biosensor for Recognizing of DNA Hybridization. Proceedings of the 2019 International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering (IC4ME2), Rajshahi, Bangladesh.","DOI":"10.1109\/IC4ME247184.2019.9036574"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1364\/OE.22.006174","article-title":"Compact surface plasmon resonance imaging sensing system based on general optoelectronic components","volume":"22","author":"Peng","year":"2014","journal-title":"Opt. Express"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hossain, M.B., and Rana, M.M. (2020, December 31). DNA Hybridization Detection Based on Resonance Frequency Readout in Graphene on Au SPR Biosensor. Available online: https:\/\/www.hindawi.com\/journals\/js\/2016\/6070742\/.","DOI":"10.1155\/2016\/6070742"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Tee, K.L., Jackson, P.J., Scarrott, J.M., Jaffe, S.R., Johnson, A.O., Johari, Y., Pohle, T.H., Mozzanino, T., Price, J., and Grinham, J. (2020). Purification of recombinant SARS-CoV-2 spike, its receptor binding domain, and CR3022 mAb for serological assay. bioRxiv.","DOI":"10.1101\/2020.07.31.231282"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kim, D., Lee, J., Bal, J., Chong, C.-K., Lee, J., and Park, H. (2021). Clinical Evaluation of an Immunochromatographic-Based IgM\/IgG Antibody Assay (GenBody\u2122 COVI040) for Detection of Antibody Seroconversion in Patients with SARS-CoV-2 Infection. Diagnostics, 11.","DOI":"10.3390\/diagnostics11030537"},{"key":"ref_28","first-page":"3","article-title":"Preparation of highly purified human IgG, IgM, and IgA for immunization and immunoanalysis","volume":"9","author":"Nikolayenko","year":"2005","journal-title":"Ukr. Bioorganica Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1128\/JCM.01094-20","article-title":"Stability of SARS-CoV-2 in Phosphate-Buffered Saline for Molecular Detection","volume":"58","author":"Perchetti","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1021\/acsnano.0c02823","article-title":"Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor","volume":"14","author":"Seo","year":"2020","journal-title":"ACS Nano"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110123","DOI":"10.1016\/j.optmat.2020.110123","article-title":"Sensitivity enhancement of SPR biosensors employing heterostructure of PtSe2 and 2D materials","volume":"107","author":"Rahman","year":"2020","journal-title":"Opt. Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.optcom.2012.10.005","article-title":"Enhanced sensitivity to surface plasmon resonance phase in wavelength-modulated heterodyne interferometry","volume":"289","author":"Lee","year":"2013","journal-title":"Opt. Commun."},{"key":"ref_33","unstructured":"Anower, S., and Rahman, M. (2021). Hybrid Heterostructures for SPR Biosensor. Biosensors."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11468-020-01204-9","article-title":"Two-dimensional PtSe2 Theoretically Enhanced Goos-H\u00e4nchen Shift Sensitive Plasmonic Biosensors","volume":"15","author":"Guo","year":"2020","journal-title":"Plasmonics"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Jia, Y., Li, Z., Wang, H., Saeed, M., and Cai, H. (2019). Sensitivity Enhancement of a Surface Plasmon Resonance Sensor with Platinum Diselenide. Sensors, 20.","DOI":"10.3390\/s20010131"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.snb.2012.08.028","article-title":"Long range surface plasmon resonance for increased sensitivity in living cell biosensing through greater probing depth","volume":"174","author":"Chabot","year":"2012","journal-title":"Sens. Actuators B Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"193701","DOI":"10.1063\/1.4921200","article-title":"Long range surface plasmon resonance with ultra-high penetration depth for self-referenced sensing and ultra-low detection limit using diverging beam approach","volume":"106","author":"Isaacs","year":"2015","journal-title":"Appl. Phys. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.37868\/sei.v2i1.27","article-title":"Fabrication of multi-mode tip fiber sensor based on surface plasmon resonance (SPR)","volume":"2","year":"2020","journal-title":"Sustain. Eng. Innov."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Fotovvati, B., Namdari, N., and Dehghanghadikolaei, A. (2019). On Coating Techniques for Surface Protection: A Review. J. Manuf. Mater. Process., 3.","DOI":"10.3390\/jmmp3010028"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1021\/acsnano.6b04898","article-title":"High-Performance Hybrid Electronic Devices from Layered PtSe2 Films Grown at Low Temperature","volume":"10","author":"Yim","year":"2016","journal-title":"ACS Nano"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"021004","DOI":"10.1088\/2053-1583\/3\/2\/021004","article-title":"Raman characterization of platinum diselenide thin films","volume":"3","author":"McEvoy","year":"2016","journal-title":"2D Mater."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep05458","article-title":"Heterojunction Hybrid Devices from Vapor Phase Grown MoS2","volume":"4","author":"Yim","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.apsusc.2014.01.103","article-title":"Controlled synthesis of transition metal dichalcogenide thin films for electronic applications","volume":"297","author":"Gatensby","year":"2014","journal-title":"Appl. Surf. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1021\/acs.nanolett.5b00964","article-title":"Monolayer PtSe2, a New Semiconducting Transition-Metal-Dichalcogenide, Epitaxially Grown by Direct Selenization of Pt","volume":"15","author":"Wang","year":"2015","journal-title":"Nano Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"045015","DOI":"10.1088\/2053-1583\/aa8919","article-title":"High quality atomically thin PtSe 2 films grown by molecular beam epitaxy","volume":"4","author":"Yan","year":"2017","journal-title":"2D Mater."},{"key":"ref_46","unstructured":"(2021, March 04). Ultra-Fast, Ultra-Sensitive PtSe2 Gas Sensors. Available online: https:\/\/phys.org\/news\/2017-01-ultra-fast-ultra-sensitive-ptse2-gas-sensors.html."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1364\/OPTICA.3.000151","article-title":"Surface plasmon resonance for characterization of large-area atomic-layer graphene film","volume":"3","author":"Jussila","year":"2016","journal-title":"Optica"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mssp.2016.03.001","article-title":"Demonstration of enhanced the photocatalytic effect with PtSe2 and TiO2 treated large area graphene obtained by CVD method","volume":"48","author":"Ye","year":"2016","journal-title":"Mater. Sci. Semicond. Process."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jelechem.2012.09.025","article-title":"Clean and efficient transfer of CVD-grown graphene by electrochemical etching of metal substrate","volume":"688","author":"Yang","year":"2013","journal-title":"J. Electroanal. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"33096","DOI":"10.1038\/srep33096","article-title":"PMMA-Etching-Free Transfer of Wafer-scale Chemical Vapor Deposition Two-dimensional Atomic Crystal by a Water Soluble Polyvinyl Alcohol Polymer Method","volume":"6","author":"Qian","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"15809","DOI":"10.1021\/acsami.7b00012","article-title":"Electronic Properties of Graphene\u2013PtSe2 Contacts","volume":"9","author":"Sattar","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1364\/OE.27.003483","article-title":"Experimental and theoretical investigation for surface plasmon resonance biosensor based on graphene\/Au film\/D-POF","volume":"27","author":"Gong","year":"2019","journal-title":"Opt. Express"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"102719","DOI":"10.1016\/j.rinp.2019.102719","article-title":"High performance refractive index SPR sensor modeling employing graphene tri sheets","volume":"15","author":"Hossain","year":"2019","journal-title":"Results Phys."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Fazio, R., Jannelli, A., and Agreste, S. (2018). A Finite Difference Method on Non-Uniform Meshes for Time-Fractional Advection\u2013Diffusion Equations with a Source Term. Appl. Sci., 8.","DOI":"10.3390\/app8060960"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Menon, P.S., Said, F.A., Mei, G.S., Berhanuddin, D.D., Umar, A.A., Shaari, S., and Majlis, B.Y. (2018). Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201228"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"037104","DOI":"10.1117\/1.OE.58.3.037104","article-title":"Numerical modeling of graphene-coated fiber optic surface plasmon resonance biosensor for BRCA1 and BRCA2 genetic breast cancer detection","volume":"58","author":"Hossain","year":"2019","journal-title":"Opt. Eng."},{"key":"ref_57","first-page":"384","article-title":"Numerical analysis of graphene coated surface plasmon resonance biosensors for biomedical applications","volume":"156","author":"Rahman","year":"2018","journal-title":"Optica"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"113101","DOI":"10.1063\/1.5066354","article-title":"Design of high-performance Au-Ag-dielectric-graphene based surface plasmon resonance biosensors using genetic algorithm","volume":"125","author":"Lin","year":"2019","journal-title":"J. Appl. Phys."},{"key":"ref_59","unstructured":"Rahman, M.S., Hossain, B., and Rana, M. (2016, January 8\u201310). Sensitivity enhancement of porous silicon based SPR sensor using graphene-M0S2 hybrid structure. Proceedings of the 2nd International Conference on Electrical, Computer & Telecommunication Engineering (ICECTE), Rajshahi, Bangladesh."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.32732\/jma.2019.8.1.13","article-title":"FDTD Analysis Fiber Optic SPR Biosensor for DNA Hybridization: A Numerical Demonstration with Graphene","volume":"8","author":"Islam","year":"2019","journal-title":"J. Mater. Appl."},{"key":"ref_61","unstructured":"(2021, March 09). De Moivre\u2019s Formula. Available online: https:\/\/en.wikipedia.org\/w\/index.php?title=De_Moivre%27s_formula&oldid=1006955752."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/s130100721","article-title":"Performance Comparison of Two Sensors Based on Surface Plasmon Resonance in a Plastic Optical Fiber","volume":"13","author":"Cennamo","year":"2013","journal-title":"Sensors"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1109\/JSEN.2018.2861829","article-title":"Performance Enhancement of SPR Biosensor Based on Phosphorene and Transition Metal Dichalcogenides for Sensing DNA Hybridization","volume":"18","author":"Meshginqalam","year":"2018","journal-title":"IEEE Sens. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2000074","DOI":"10.1002\/adts.202000074","article-title":"Investigation of Plasmonic Detection of Human Respiratory Virus","volume":"3","author":"Das","year":"2020","journal-title":"Adv. Theory Simulations"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2000185","DOI":"10.1002\/adts.202000185","article-title":"Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID-19 SARS-CoV-2 Spike Protein","volume":"3","author":"Das","year":"2020","journal-title":"Adv. Theory Simul."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ouyang, Q., Zeng, S., Jiang, L., Hong, L., Xu, G., Dinh, X.Q., Qian, J., He, S., Qu, J., and Coquet, P. (2016). Sensitivity Enhancement of Transition Metal Dichalcogenides\/Silicon Nanostructure-based Surface Plasmon Resonance Biosensor. Sci. Rep., 6.","DOI":"10.1038\/srep28190"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"035011","DOI":"10.1088\/2053-1583\/ab1490","article-title":"Optical properties of chemical vapor deposition-grown PtSe 2 characterized by spectroscopic ellipsometry","volume":"6","author":"Xie","year":"2019","journal-title":"2D Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"031901","DOI":"10.1063\/1.3073717","article-title":"Optical constants of graphene layers in the visible range","volume":"94","author":"Bruna","year":"2009","journal-title":"Appl. Phys. Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1109\/JSEN.2015.2442276","article-title":"Graphene Enhances the Sensitivity of Fiber-Optic Surface Plasmon Resonance Biosensor","volume":"15","author":"Fu","year":"2015","journal-title":"IEEE Sens. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.optcom.2016.09.015","article-title":"Graphene coated fiber optic surface plasmon resonance biosensor for the DNA hybridization detection: Simulation analysis","volume":"383","author":"Shushama","year":"2017","journal-title":"Opt. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1166\/sl.2016.3596","article-title":"Graphene Coated High Sensitive Surface Plasmon Resonance Biosensor for Sensing DNA Hybridization","volume":"14","author":"Hossain","year":"2016","journal-title":"Sens. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbamem.2013.04.028","article-title":"Surface plasmon resonance spectroscopy for characterisation of membrane protein\u2013ligand interactions and its potential for drug discovery","volume":"1838","author":"Patching","year":"2014","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1039\/C4MD00088A","article-title":"Surface plasmon resonance for the characterization of bacterial polysaccharide antigens: A review","volume":"5","author":"Brogioni","year":"2014","journal-title":"MedChemComm"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Schasfoort, R.B.M. (2017). Chapter 1. Introduction to Surface Plasmon Resonance. Handbook of Surface Plasmon Resonance, Royal Society of Chemistry (RSC).","DOI":"10.1039\/9781788010283-00001"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"113001","DOI":"10.1088\/0022-3727\/45\/11\/113001","article-title":"Surface plasmon polaritons: Physics and applications","volume":"45","author":"Zhang","year":"2012","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11520","DOI":"10.1021\/acs.analchem.0c02475","article-title":"Advanced Analysis of Biosensor Data for SARS-CoV-2 RBD and ACE2 Interactions","volume":"92","author":"Samuelsson","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1021\/acs.analchem.8b00504","article-title":"Reliable Strategy for Analysis of Complex Biosensor Data","volume":"90","author":"Multia","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/22221751.2020.1729069","article-title":"Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody","volume":"9","author":"Tian","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_80","first-page":"1","article-title":"Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1126\/science.abc5881","article-title":"Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody","volume":"369","author":"Lv","year":"2020","journal-title":"Science"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wee, S.K., Sivalingam, S.P., and Yap, E.P.H. (2020). Rapid Direct Nucleic Acid Amplification Test without RNA Extraction for SARS-CoV-2 Using a Portable PCR Thermocycler. Genes, 11.","DOI":"10.1101\/2020.04.17.042366"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41591-020-0817-4","article-title":"Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding","volume":"26","author":"Xu","year":"2020","journal-title":"Nat. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.7150\/thno.47649","article-title":"Primer design for quantitative real-time PCR for the emerging Coronavirus SARS-CoV-2","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41591-020-0897-1","article-title":"Antibody responses to SARS-CoV-2 in patients with COVID-19","volume":"26","author":"Long","year":"2020","journal-title":"Nat. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41415-020-2228-9","article-title":"Non-infectious status indicated by detectable IgG antibody to SARS-CoV-2","volume":"229","author":"Denning","year":"2020","journal-title":"Br. Dent. J."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/10\/3491\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:02:44Z","timestamp":1760162564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/21\/10\/3491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":86,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["s21103491"],"URL":"https:\/\/doi.org\/10.3390\/s21103491","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,17]]}}}